Incidental Mutation 'IGL00791:Zfp935'
| ID |
15012 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp935
|
| Ensembl Gene |
ENSMUSG00000055228 |
| Gene Name |
zinc finger protein 935 |
| Synonyms |
8430426H19Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.173)
|
| Stock # |
IGL00791
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
13 |
| Chromosomal Location |
62600830-62614626 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 62602278 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 307
(N307K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000152662
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000076195]
[ENSMUST00000221747]
[ENSMUST00000223247]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000076195
|
| SMART Domains |
Protein: ENSMUSP00000075552
Gene: ENSMUSG00000055228
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
66 |
8.26e-16 |
SMART |
|
ZnF_C2H2
|
133 |
155 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
161 |
183 |
1.4e-4 |
SMART |
|
ZnF_C2H2
|
189 |
211 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
217 |
239 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
245 |
267 |
7.26e-3 |
SMART |
|
ZnF_C2H2
|
273 |
295 |
1.4e-4 |
SMART |
|
ZnF_C2H2
|
301 |
323 |
8.6e-5 |
SMART |
|
ZnF_C2H2
|
329 |
351 |
1.2e-3 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000221260
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000221747
AA Change: N307K
PolyPhen 2
Score 0.326 (Sensitivity: 0.90; Specificity: 0.89)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000221951
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000223247
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 21 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Asap2 |
A |
T |
12: 21,289,649 (GRCm39) |
M519L |
possibly damaging |
Het |
| Bbs7 |
T |
C |
3: 36,629,436 (GRCm39) |
*674W |
probably null |
Het |
| Ceacam13 |
A |
G |
7: 17,747,278 (GRCm39) |
T244A |
possibly damaging |
Het |
| Cln8 |
T |
A |
8: 14,944,689 (GRCm39) |
M1K |
probably null |
Het |
| Cnot9 |
T |
C |
1: 74,561,533 (GRCm39) |
V126A |
probably benign |
Het |
| Enpep |
T |
C |
3: 129,125,731 (GRCm39) |
T134A |
possibly damaging |
Het |
| Fastkd5 |
C |
A |
2: 130,458,297 (GRCm39) |
A98S |
probably benign |
Het |
| Gsdmc |
A |
T |
15: 63,676,284 (GRCm39) |
I53N |
possibly damaging |
Het |
| Hexd |
A |
G |
11: 121,111,986 (GRCm39) |
S427G |
probably benign |
Het |
| Lrrk2 |
T |
G |
15: 91,664,044 (GRCm39) |
L1927R |
probably damaging |
Het |
| Mia2 |
A |
G |
12: 59,155,085 (GRCm39) |
E267G |
possibly damaging |
Het |
| Plec |
A |
G |
15: 76,057,137 (GRCm39) |
S4132P |
probably damaging |
Het |
| Rtn3 |
A |
G |
19: 7,412,434 (GRCm39) |
L780P |
probably damaging |
Het |
| Serpinb9c |
A |
T |
13: 33,335,867 (GRCm39) |
V195E |
probably damaging |
Het |
| Slit2 |
T |
C |
5: 48,461,374 (GRCm39) |
Y1474H |
possibly damaging |
Het |
| Taf15 |
A |
G |
11: 83,379,749 (GRCm39) |
|
probably null |
Het |
| Tbc1d17 |
A |
G |
7: 44,494,737 (GRCm39) |
S194P |
probably benign |
Het |
| Tbc1d2b |
T |
C |
9: 90,109,481 (GRCm39) |
S332G |
probably benign |
Het |
| Tmpo |
A |
T |
10: 90,998,420 (GRCm39) |
S456T |
possibly damaging |
Het |
| Tubgcp2 |
A |
G |
7: 139,581,411 (GRCm39) |
L608P |
probably damaging |
Het |
| Zfp39 |
T |
A |
11: 58,783,885 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Zfp935 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02169:Zfp935
|
APN |
13 |
62,604,745 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02570:Zfp935
|
APN |
13 |
62,604,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02756:Zfp935
|
APN |
13 |
62,602,701 (GRCm39) |
nonsense |
probably null |
|
|
IGL03338:Zfp935
|
APN |
13 |
62,602,247 (GRCm39) |
missense |
probably benign |
0.11 |
|
R1252:Zfp935
|
UTSW |
13 |
62,602,355 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1503:Zfp935
|
UTSW |
13 |
62,602,951 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2425:Zfp935
|
UTSW |
13 |
62,602,922 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3720:Zfp935
|
UTSW |
13 |
62,602,846 (GRCm39) |
nonsense |
probably null |
|
|
R4819:Zfp935
|
UTSW |
13 |
62,602,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5391:Zfp935
|
UTSW |
13 |
62,602,632 (GRCm39) |
nonsense |
probably null |
|
|
R6253:Zfp935
|
UTSW |
13 |
62,602,685 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6742:Zfp935
|
UTSW |
13 |
62,602,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9447:Zfp935
|
UTSW |
13 |
62,602,842 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
| Posted On |
2012-12-06 |
Incidental Mutation