Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00743:Zfp938'

15013

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp938

Ensembl Gene

ENSMUSG00000062931

Gene Name

zinc finger protein 938

Synonyms

B230315N10Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.075) question?

Stock #

IGL00743

Quality Score

Status

Chromosome

Chromosomal Location

82060684-82077114 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 82062317 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 101 (M101K)

Ref Sequence

ENSEMBL: ENSMUSP00000047110 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041264] [ENSMUST00000156218]

AlphaFold

E9Q9G3

Predicted Effect

probably benign
Transcript: ENSMUST00000041264
AA Change: M101K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000047110
Gene: ENSMUSG00000062931
AA Change: M101K

Domain	Start	End	E-Value	Type
KRAB	4	64	5.28e-14	SMART
ZnF_C2H2	161	188	2.82e1	SMART
ZnF_C2H2	267	289	1.23e0	SMART
ZnF_C2H2	295	317	2.91e-2	SMART
ZnF_C2H2	323	345	2.4e-3	SMART
ZnF_C2H2	351	373	7.26e-3	SMART
ZnF_C2H2	379	401	4.65e-1	SMART
ZnF_C2H2	407	429	1.47e-3	SMART
ZnF_C2H2	435	457	5.59e-4	SMART
ZnF_C2H2	463	485	1.82e-3	SMART
ZnF_C2H2	491	513	3.63e-3	SMART
ZnF_C2H2	519	541	7.67e-2	SMART
ZnF_C2H2	547	569	2.4e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000156218

SMART Domains

Protein: ENSMUSP00000121613
Gene: ENSMUSG00000062931

Domain	Start	End	E-Value	Type
KRAB	4	64	5.28e-14	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acss1	T	C	2: 150,461,606 (GRCm39)	E659G	probably benign	Het
Adgrg6	A	C	10: 14,411,703 (GRCm39)		probably benign	Het
Als2cl	A	G	9: 110,718,227 (GRCm39)	K323E	possibly damaging	Het
Atm	A	C	9: 53,424,416 (GRCm39)	S628R	probably benign	Het
Baz2a	T	C	10: 127,950,395 (GRCm39)	V443A	probably benign	Het
Bclaf3	T	A	X: 158,341,357 (GRCm39)	F545Y	probably benign	Het
Calcr	T	C	6: 3,717,196 (GRCm39)	Y88C	probably damaging	Het
Ccdc178	C	T	18: 22,278,501 (GRCm39)		probably benign	Het
Cdh20	A	G	1: 104,875,153 (GRCm39)	T312A	probably benign	Het
Chrnd	G	A	1: 87,120,649 (GRCm39)	W91*	probably null	Het
Cntln	T	C	4: 84,897,652 (GRCm39)	F413S	probably benign	Het
Ctsq	A	T	13: 61,183,998 (GRCm39)	I308N	probably damaging	Het
Cyp2d34	A	T	15: 82,501,736 (GRCm39)	V258D	probably damaging	Het
Dnajc13	G	A	9: 104,039,979 (GRCm39)	P2044S	probably benign	Het
Hnrnpm	C	A	17: 33,868,876 (GRCm39)	R517L	probably damaging	Het
Hps6	A	T	19: 45,992,099 (GRCm39)	D12V	probably damaging	Het
Hpse	T	C	5: 100,846,865 (GRCm39)	D188G	probably benign	Het
Id2	C	A	12: 25,145,355 (GRCm39)	E123*	probably null	Het
Ints10	C	T	8: 69,271,985 (GRCm39)	P562L	probably damaging	Het
Kctd10	G	A	5: 114,505,410 (GRCm39)	R195C	probably damaging	Het
Kel	A	C	6: 41,665,509 (GRCm39)	L537R	probably damaging	Het
Kif19a	T	C	11: 114,675,599 (GRCm39)	V357A	probably damaging	Het
Lrrtm3	A	T	10: 63,924,988 (GRCm39)	S60T	probably damaging	Het
Myof	C	A	19: 37,949,382 (GRCm39)	R608L	probably benign	Het
Naa35	A	T	13: 59,778,485 (GRCm39)	I669F	probably benign	Het
Or8g2b	A	T	9: 39,751,002 (GRCm39)	I91F	probably benign	Het
Or8g53	A	G	9: 39,683,407 (GRCm39)	S230P	possibly damaging	Het
Pclo	G	T	5: 14,728,035 (GRCm39)		probably benign	Het
Pik3c3	C	T	18: 30,407,417 (GRCm39)	S55F	probably damaging	Het
Prdm6	T	G	18: 53,673,300 (GRCm39)	D153E	possibly damaging	Het
Rnf183	T	C	4: 62,346,610 (GRCm39)	T63A	probably benign	Het
Samd4b	A	C	7: 28,101,302 (GRCm39)	I108S	probably damaging	Het
Slc9a7	T	C	X: 19,972,260 (GRCm39)	D708G	possibly damaging	Het
Stim2	A	G	5: 54,210,835 (GRCm39)	D90G	probably benign	Het
Tmem52b	A	G	6: 129,493,678 (GRCm39)	D97G	probably damaging	Het
Tnfsf15	T	C	4: 63,652,518 (GRCm39)	R98G	probably benign	Het
Uxs1	C	T	1: 43,796,173 (GRCm39)	V310I	probably benign	Het
Vcan	A	C	13: 89,873,425 (GRCm39)	M143R	probably damaging	Het
Vmn2r93	T	C	17: 18,546,504 (GRCm39)	F792S	probably damaging	Het
Zfp455	T	C	13: 67,355,962 (GRCm39)	I345T	probably benign	Het
Zkscan2	A	G	7: 123,079,195 (GRCm39)	S921P	probably damaging	Het

Other mutations in Zfp938

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00659:Zfp938	APN	10	82,063,355 (GRCm39)	utr 3 prime	probably benign
IGL01764:Zfp938	APN	10	82,063,624 (GRCm39)	splice site	probably benign
IGL01814:Zfp938	APN	10	82,062,052 (GRCm39)	missense	probably benign
IGL02244:Zfp938	APN	10	82,061,906 (GRCm39)	missense	possibly damaging	0.86
IGL02865:Zfp938	APN	10	82,062,026 (GRCm39)	missense	probably benign	0.33
R0372:Zfp938	UTSW	10	82,063,662 (GRCm39)	missense	probably damaging	1.00
R0666:Zfp938	UTSW	10	82,061,606 (GRCm39)	missense	probably damaging	1.00
R0964:Zfp938	UTSW	10	82,061,253 (GRCm39)	missense	probably benign	0.00
R1453:Zfp938	UTSW	10	82,063,632 (GRCm39)	critical splice donor site	probably null
R1672:Zfp938	UTSW	10	82,060,982 (GRCm39)	missense	probably benign
R1929:Zfp938	UTSW	10	82,061,381 (GRCm39)	missense	probably damaging	1.00
R1959:Zfp938	UTSW	10	82,061,465 (GRCm39)	missense	probably damaging	1.00
R2127:Zfp938	UTSW	10	82,061,876 (GRCm39)	missense	probably benign
R2271:Zfp938	UTSW	10	82,061,381 (GRCm39)	missense	probably damaging	1.00
R2900:Zfp938	UTSW	10	82,061,340 (GRCm39)	missense	possibly damaging	0.92
R4502:Zfp938	UTSW	10	82,062,105 (GRCm39)	missense	possibly damaging	0.73
R4503:Zfp938	UTSW	10	82,062,105 (GRCm39)	missense	possibly damaging	0.73
R4886:Zfp938	UTSW	10	82,061,957 (GRCm39)	missense	probably benign	0.33
R4934:Zfp938	UTSW	10	82,062,012 (GRCm39)	missense	possibly damaging	0.86
R5174:Zfp938	UTSW	10	82,061,838 (GRCm39)	missense	possibly damaging	0.53
R5410:Zfp938	UTSW	10	82,061,092 (GRCm39)	missense	possibly damaging	0.89
R6284:Zfp938	UTSW	10	82,063,400 (GRCm39)	missense	possibly damaging	0.73
R6491:Zfp938	UTSW	10	82,063,363 (GRCm39)	makesense	probably null
R6575:Zfp938	UTSW	10	82,061,160 (GRCm39)	nonsense	probably null
R6649:Zfp938	UTSW	10	82,061,232 (GRCm39)	missense	probably damaging	0.99
R7992:Zfp938	UTSW	10	82,061,777 (GRCm39)	missense	possibly damaging	0.53
R8211:Zfp938	UTSW	10	82,062,419 (GRCm39)	missense	possibly damaging	0.53
R8313:Zfp938	UTSW	10	82,061,422 (GRCm39)	missense	possibly damaging	0.75
R8963:Zfp938	UTSW	10	82,061,287 (GRCm39)	missense	possibly damaging	0.61
X0066:Zfp938	UTSW	10	82,061,931 (GRCm39)	missense	probably benign	0.33

Posted On

2012-12-06