Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00159:Vmn2r57'

1503

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r57

Ensembl Gene

ENSMUSG00000066537

Gene Name

vomeronasal 2, receptor 57

Synonyms

EG269902

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.113) question?

Stock #

IGL00159

Quality Score

Status

Chromosome

Chromosomal Location

41399732-41448641 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 41428785 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 83 (M83K)

Ref Sequence

ENSEMBL: ENSMUSP00000125817 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094532] [ENSMUST00000165029]

AlphaFold

L7N269

Predicted Effect

probably benign
Transcript: ENSMUST00000094532

Predicted Effect

probably benign
Transcript: ENSMUST00000165029
AA Change: M83K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000125817
Gene: ENSMUSG00000066537
AA Change: M83K

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	471	1.4e-44	PFAM
Pfam:NCD3G	514	567	2.7e-23	PFAM
Pfam:7tm_3	600	835	1.8e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9030624J02Rik	G	A	7: 118,797,047		probably null	Het
Axin1	A	T	17: 26,142,805	D41V	possibly damaging	Het
BC034090	C	A	1: 155,225,451	E718*	probably null	Het
Cdc123	G	T	2: 5,804,935	Q222K	probably benign	Het
Clip1	A	C	5: 123,603,654	V1053G	possibly damaging	Het
Dock7	T	A	4: 99,063,985	E416V	probably damaging	Het
Dydc1	T	C	14: 41,087,413	L143P	probably damaging	Het
Dync2h1	A	G	9: 7,158,839	V732A	probably benign	Het
Dzip1l	T	A	9: 99,637,777	L119Q	probably damaging	Het
Erp27	T	A	6: 136,909,502	S178C	probably damaging	Het
Fbn1	A	G	2: 125,397,873	V298A	probably benign	Het
Fbxo34	A	G	14: 47,529,474	H97R	probably damaging	Het
Gm20521	C	T	14: 54,884,622	Q81*	probably null	Het
Gspt1	T	C	16: 11,222,612	M610V	probably damaging	Het
Herc1	A	G	9: 66,437,682	Q1919R	possibly damaging	Het
Il19	A	G	1: 130,935,055		probably benign	Het
Kif14	G	A	1: 136,469,018	S354N	probably benign	Het
Lrrk2	A	G	15: 91,747,799	K1309E	possibly damaging	Het
Lurap1	T	C	4: 116,137,690	T115A	probably damaging	Het
Myo18b	G	T	5: 112,874,131	T465K	probably benign	Het
Nwd1	A	T	8: 72,671,077	D648V	probably damaging	Het
Olfr272	T	G	4: 52,911,618	M59L	possibly damaging	Het
Olfr520	G	A	7: 99,735,317	R58H	probably benign	Het
Otof	T	C	5: 30,375,904	Y1527C	probably damaging	Het
Otop3	G	A	11: 115,344,397	C285Y	probably damaging	Het
Parp3	A	G	9: 106,471,387	I478T	probably benign	Het
Pdzd2	C	T	15: 12,457,983	E265K	possibly damaging	Het
Pik3c2g	T	C	6: 139,896,125	L634P	probably damaging	Het
Prkg1	C	A	19: 31,302,340	V165L	probably benign	Het
Riok3	A	G	18: 12,148,891	I306V	possibly damaging	Het
Ror2	T	C	13: 53,113,082	D439G	probably benign	Het
Scn2a	T	A	2: 65,743,090	I1428N	probably damaging	Het
Sgcg	C	T	14: 61,232,475	D146N	probably benign	Het
Slc16a9	A	G	10: 70,282,699	R283G	probably benign	Het
Sptb	T	C	12: 76,621,331	D664G	probably benign	Het
Tmprss3	T	A	17: 31,195,008	D54V	probably damaging	Het
Ttc37	T	C	13: 76,143,278		probably null	Het
Tubd1	G	T	11: 86,565,729	V374F	probably benign	Het
Vps13c	A	G	9: 67,945,999	E2458G	probably benign	Het
Zhx2	A	T	15: 57,822,870	E545V	probably damaging	Het

Other mutations in Vmn2r57

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01108:Vmn2r57	APN	7	41,427,584 (GRCm38)	missense	probably benign	0.01
IGL01112:Vmn2r57	APN	7	41,425,043 (GRCm38)	missense	probably damaging	1.00
IGL01516:Vmn2r57	APN	7	41,399,946 (GRCm38)	missense	probably damaging	1.00
IGL01880:Vmn2r57	APN	7	41,400,195 (GRCm38)	missense	possibly damaging	0.73
IGL02117:Vmn2r57	APN	7	41,400,450 (GRCm38)	missense	probably benign	0.00
IGL02500:Vmn2r57	APN	7	41,428,226 (GRCm38)	missense	probably benign
IGL02801:Vmn2r57	APN	7	41,448,632 (GRCm38)	missense	probably benign	0.13
IGL02993:Vmn2r57	APN	7	41,428,074 (GRCm38)	missense	probably benign	0.04
IGL02996:Vmn2r57	APN	7	41,399,741 (GRCm38)	missense	probably benign	0.02
R0008:Vmn2r57	UTSW	7	41,400,652 (GRCm38)	missense	probably damaging	1.00
R0032:Vmn2r57	UTSW	7	41,399,733 (GRCm38)	splice site	probably null
R0305:Vmn2r57	UTSW	7	41,427,543 (GRCm38)	missense	probably benign	0.00
R0469:Vmn2r57	UTSW	7	41,427,792 (GRCm38)	missense	possibly damaging	0.58
R0510:Vmn2r57	UTSW	7	41,427,792 (GRCm38)	missense	possibly damaging	0.58
R0847:Vmn2r57	UTSW	7	41,428,801 (GRCm38)	missense	probably benign	0.00
R1025:Vmn2r57	UTSW	7	41,427,804 (GRCm38)	missense	probably benign	0.24
R1081:Vmn2r57	UTSW	7	41,428,211 (GRCm38)	missense	possibly damaging	0.47
R1479:Vmn2r57	UTSW	7	41,427,830 (GRCm38)	missense	possibly damaging	0.45
R1579:Vmn2r57	UTSW	7	41,400,124 (GRCm38)	missense	probably benign	0.38
R1764:Vmn2r57	UTSW	7	41,400,643 (GRCm38)	missense	probably damaging	1.00
R1848:Vmn2r57	UTSW	7	41,428,107 (GRCm38)	missense	probably damaging	1.00
R2006:Vmn2r57	UTSW	7	41,448,577 (GRCm38)	missense	probably benign	0.00
R2197:Vmn2r57	UTSW	7	41,428,825 (GRCm38)	critical splice acceptor site	probably null
R2242:Vmn2r57	UTSW	7	41,428,074 (GRCm38)	missense	probably benign	0.00
R2394:Vmn2r57	UTSW	7	41,400,195 (GRCm38)	missense	possibly damaging	0.73
R3937:Vmn2r57	UTSW	7	41,428,130 (GRCm38)	missense	probably damaging	0.97
R4193:Vmn2r57	UTSW	7	41,428,239 (GRCm38)	missense	probably benign
R4423:Vmn2r57	UTSW	7	41,426,640 (GRCm38)	missense	probably damaging	1.00
R4865:Vmn2r57	UTSW	7	41,400,468 (GRCm38)	missense	probably damaging	1.00
R4947:Vmn2r57	UTSW	7	41,400,495 (GRCm38)	missense	probably damaging	1.00
R5042:Vmn2r57	UTSW	7	41,428,662 (GRCm38)	missense	probably benign	0.06
R5084:Vmn2r57	UTSW	7	41,426,550 (GRCm38)	critical splice donor site	probably null
R5177:Vmn2r57	UTSW	7	41,400,240 (GRCm38)	missense	probably benign	0.31
R5192:Vmn2r57	UTSW	7	41,427,939 (GRCm38)	missense	probably damaging	0.96
R5289:Vmn2r57	UTSW	7	41,399,974 (GRCm38)	missense	probably damaging	0.99
R5745:Vmn2r57	UTSW	7	41,448,471 (GRCm38)	missense	possibly damaging	0.51
R6051:Vmn2r57	UTSW	7	41,448,472 (GRCm38)	missense	probably benign	0.00
R6155:Vmn2r57	UTSW	7	41,428,690 (GRCm38)	missense	probably benign	0.14
R6248:Vmn2r57	UTSW	7	41,399,860 (GRCm38)	missense	probably benign
R6381:Vmn2r57	UTSW	7	41,428,818 (GRCm38)	missense	probably benign	0.08
R7019:Vmn2r57	UTSW	7	41,428,665 (GRCm38)	missense	probably damaging	1.00
R7126:Vmn2r57	UTSW	7	41,399,794 (GRCm38)	missense	possibly damaging	0.93
R7146:Vmn2r57	UTSW	7	41,448,471 (GRCm38)	missense	possibly damaging	0.51
R7215:Vmn2r57	UTSW	7	41,400,286 (GRCm38)	missense	probably benign	0.00
R7432:Vmn2r57	UTSW	7	41,426,724 (GRCm38)	missense	probably benign	0.01
R7633:Vmn2r57	UTSW	7	41,425,089 (GRCm38)	missense	possibly damaging	0.76
R7811:Vmn2r57	UTSW	7	41,425,015 (GRCm38)	nonsense	probably null
R8025:Vmn2r57	UTSW	7	41,426,759 (GRCm38)	missense	probably benign	0.00
R8332:Vmn2r57	UTSW	7	41,400,253 (GRCm38)	missense	probably benign	0.01
R8345:Vmn2r57	UTSW	7	41,427,544 (GRCm38)	missense	possibly damaging	0.81
R8360:Vmn2r57	UTSW	7	41,400,216 (GRCm38)	missense	probably damaging	1.00
R8738:Vmn2r57	UTSW	7	41,427,596 (GRCm38)	missense	probably benign	0.00
R8758:Vmn2r57	UTSW	7	41,428,739 (GRCm38)	missense	probably damaging	1.00
R8955:Vmn2r57	UTSW	7	41,400,147 (GRCm38)	missense	possibly damaging	0.64
R8985:Vmn2r57	UTSW	7	41,399,835 (GRCm38)	missense	probably benign
R9108:Vmn2r57	UTSW	7	41,428,768 (GRCm38)	missense	possibly damaging	0.87
R9160:Vmn2r57	UTSW	7	41,426,735 (GRCm38)	missense	possibly damaging	0.48
R9354:Vmn2r57	UTSW	7	41,400,239 (GRCm38)	missense	probably benign	0.01
R9566:Vmn2r57	UTSW	7	41,427,665 (GRCm38)	missense	probably benign	0.32
R9633:Vmn2r57	UTSW	7	41,426,582 (GRCm38)	missense	probably benign	0.00
X0026:Vmn2r57	UTSW	7	41,428,561 (GRCm38)	missense	possibly damaging	0.91
X0026:Vmn2r57	UTSW	7	41,428,125 (GRCm38)	missense	probably benign	0.03
X0065:Vmn2r57	UTSW	7	41,427,971 (GRCm38)	missense	probably benign	0.09
Z1176:Vmn2r57	UTSW	7	41,400,498 (GRCm38)	missense	probably damaging	0.99

Posted On

2011-07-12