Incidental Mutation 'IGL00775:Zscan21'
ID15058
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zscan21
Ensembl Gene ENSMUSG00000037017
Gene Namezinc finger and SCAN domain containing 21
SynonymsRU49, Zipro1, Zfp38, CTfin51, Zfp-38
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00775
Quality Score
Status
Chromosome5
Chromosomal Location138116903-138134265 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) C to A at 138133048 bp
ZygosityHeterozygous
Amino Acid Change Serine to Stop codon at position 99 (S99*)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062350] [ENSMUST00000080732] [ENSMUST00000110959] [ENSMUST00000110960] [ENSMUST00000110961]
Predicted Effect probably null
Transcript: ENSMUST00000062350
AA Change: S278*
SMART Domains Protein: ENSMUSP00000053430
Gene: ENSMUSG00000037017
AA Change: S278*

DomainStartEndE-ValueType
low complexity region 28 37 N/A INTRINSIC
SCAN 118 230 1.7e-80 SMART
ZnF_C2H2 359 381 3.95e-4 SMART
ZnF_C2H2 387 409 4.87e-4 SMART
ZnF_C2H2 415 436 1.26e1 SMART
ZnF_C2H2 442 464 4.3e-5 SMART
ZnF_C2H2 470 492 3.95e-4 SMART
ZnF_C2H2 498 520 1.38e-3 SMART
ZnF_C2H2 526 548 2.2e-2 SMART
Predicted Effect probably null
Transcript: ENSMUST00000080732
AA Change: S278*
SMART Domains Protein: ENSMUSP00000079557
Gene: ENSMUSG00000037017
AA Change: S278*

DomainStartEndE-ValueType
low complexity region 28 37 N/A INTRINSIC
SCAN 118 230 1.7e-80 SMART
ZnF_C2H2 359 381 3.95e-4 SMART
ZnF_C2H2 387 409 4.87e-4 SMART
ZnF_C2H2 415 436 1.26e1 SMART
ZnF_C2H2 442 464 4.3e-5 SMART
ZnF_C2H2 470 492 3.95e-4 SMART
ZnF_C2H2 498 520 1.38e-3 SMART
ZnF_C2H2 526 548 2.2e-2 SMART
Predicted Effect probably null
Transcript: ENSMUST00000110959
AA Change: S278*
SMART Domains Protein: ENSMUSP00000106584
Gene: ENSMUSG00000037017
AA Change: S278*

DomainStartEndE-ValueType
low complexity region 28 37 N/A INTRINSIC
SCAN 118 230 1.7e-80 SMART
ZnF_C2H2 359 381 3.95e-4 SMART
ZnF_C2H2 387 409 4.87e-4 SMART
ZnF_C2H2 415 436 1.26e1 SMART
ZnF_C2H2 442 464 4.3e-5 SMART
ZnF_C2H2 470 492 3.95e-4 SMART
ZnF_C2H2 498 520 1.38e-3 SMART
ZnF_C2H2 526 548 2.2e-2 SMART
Predicted Effect probably null
Transcript: ENSMUST00000110960
AA Change: S278*
SMART Domains Protein: ENSMUSP00000106585
Gene: ENSMUSG00000037017
AA Change: S278*

DomainStartEndE-ValueType
low complexity region 28 37 N/A INTRINSIC
SCAN 118 230 1.7e-80 SMART
ZnF_C2H2 359 381 3.95e-4 SMART
ZnF_C2H2 387 409 4.87e-4 SMART
ZnF_C2H2 415 436 1.26e1 SMART
ZnF_C2H2 442 464 4.3e-5 SMART
ZnF_C2H2 470 492 3.95e-4 SMART
ZnF_C2H2 498 520 1.38e-3 SMART
ZnF_C2H2 526 548 2.2e-2 SMART
Predicted Effect probably null
Transcript: ENSMUST00000110961
AA Change: S278*
SMART Domains Protein: ENSMUSP00000106586
Gene: ENSMUSG00000037017
AA Change: S278*

DomainStartEndE-ValueType
low complexity region 28 37 N/A INTRINSIC
SCAN 118 230 1.7e-80 SMART
ZnF_C2H2 359 381 3.95e-4 SMART
ZnF_C2H2 387 409 4.87e-4 SMART
ZnF_C2H2 415 436 1.26e1 SMART
ZnF_C2H2 442 464 4.3e-5 SMART
ZnF_C2H2 470 492 3.95e-4 SMART
ZnF_C2H2 498 520 1.38e-3 SMART
ZnF_C2H2 526 548 2.2e-2 SMART
Predicted Effect probably null
Transcript: ENSMUST00000142185
AA Change: S99*
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygotes for a targeted null mutation appear to be phenotypically normal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 13 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700007G11Rik T C 5: 98,784,510 Y190H probably benign Het
Acsm1 A G 7: 119,658,301 N403S possibly damaging Het
Adam32 T C 8: 24,921,354 Y92C probably damaging Het
Ankfy1 G A 11: 72,728,772 G157D probably benign Het
Champ1 T C 8: 13,879,509 S556P probably damaging Het
Dnah8 T G 17: 30,767,906 Y3176* probably null Het
Gbp8 T C 5: 105,017,845 N314S probably damaging Het
Kif1c A G 11: 70,724,134 probably null Het
Pcdhb22 T C 18: 37,519,742 V421A probably benign Het
Plag1 A G 4: 3,904,055 S379P probably damaging Het
Skint11 A T 4: 114,194,692 D79V probably damaging Het
Tdp2 A G 13: 24,840,538 T273A probably damaging Het
Utrn A G 10: 12,745,230 probably null Het
Other mutations in Zscan21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02348:Zscan21 APN 5 138133383 missense probably damaging 0.99
IGL03295:Zscan21 APN 5 138125278 missense possibly damaging 0.85
R0454:Zscan21 UTSW 5 138133603 missense possibly damaging 0.77
R0471:Zscan21 UTSW 5 138125140 missense probably benign 0.33
R1465:Zscan21 UTSW 5 138125208 missense probably benign 0.18
R1465:Zscan21 UTSW 5 138125208 missense probably benign 0.18
R1860:Zscan21 UTSW 5 138126630 missense probably benign 0.00
R5498:Zscan21 UTSW 5 138133260 missense probably benign
R5851:Zscan21 UTSW 5 138126478 missense probably benign 0.39
R6213:Zscan21 UTSW 5 138125097 missense probably benign 0.09
R7079:Zscan21 UTSW 5 138126466 missense probably benign 0.11
R7448:Zscan21 UTSW 5 138117848 start gained probably benign
R8436:Zscan21 UTSW 5 138117916 missense unknown
Posted On2012-12-06