Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00775:Zscan21'

15058

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zscan21

Ensembl Gene

ENSMUSG00000037017

Gene Name

zinc finger and SCAN domain containing 21

Synonyms

RU49, Zfp-38, Zfp38, Zipro1, CTfin51

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00775

Quality Score

Status

Chromosome

Chromosomal Location

138115165-138132527 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to A at 138131310 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Stop codon at position 99 (S99*)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000062350] [ENSMUST00000080732] [ENSMUST00000110959] [ENSMUST00000110960] [ENSMUST00000110961]

AlphaFold

Q07231

Predicted Effect

probably null
Transcript: ENSMUST00000062350
AA Change: S278*

SMART Domains

Protein: ENSMUSP00000053430
Gene: ENSMUSG00000037017
AA Change: S278*

Domain	Start	End	E-Value	Type
low complexity region	28	37	N/A	INTRINSIC
SCAN	118	230	1.7e-80	SMART
ZnF_C2H2	359	381	3.95e-4	SMART
ZnF_C2H2	387	409	4.87e-4	SMART
ZnF_C2H2	415	436	1.26e1	SMART
ZnF_C2H2	442	464	4.3e-5	SMART
ZnF_C2H2	470	492	3.95e-4	SMART
ZnF_C2H2	498	520	1.38e-3	SMART
ZnF_C2H2	526	548	2.2e-2	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000080732
AA Change: S278*

SMART Domains

Protein: ENSMUSP00000079557
Gene: ENSMUSG00000037017
AA Change: S278*

Domain	Start	End	E-Value	Type
low complexity region	28	37	N/A	INTRINSIC
SCAN	118	230	1.7e-80	SMART
ZnF_C2H2	359	381	3.95e-4	SMART
ZnF_C2H2	387	409	4.87e-4	SMART
ZnF_C2H2	415	436	1.26e1	SMART
ZnF_C2H2	442	464	4.3e-5	SMART
ZnF_C2H2	470	492	3.95e-4	SMART
ZnF_C2H2	498	520	1.38e-3	SMART
ZnF_C2H2	526	548	2.2e-2	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000110959
AA Change: S278*

SMART Domains

Protein: ENSMUSP00000106584
Gene: ENSMUSG00000037017
AA Change: S278*

Domain	Start	End	E-Value	Type
low complexity region	28	37	N/A	INTRINSIC
SCAN	118	230	1.7e-80	SMART
ZnF_C2H2	359	381	3.95e-4	SMART
ZnF_C2H2	387	409	4.87e-4	SMART
ZnF_C2H2	415	436	1.26e1	SMART
ZnF_C2H2	442	464	4.3e-5	SMART
ZnF_C2H2	470	492	3.95e-4	SMART
ZnF_C2H2	498	520	1.38e-3	SMART
ZnF_C2H2	526	548	2.2e-2	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000110960
AA Change: S278*

SMART Domains

Protein: ENSMUSP00000106585
Gene: ENSMUSG00000037017
AA Change: S278*

Domain	Start	End	E-Value	Type
low complexity region	28	37	N/A	INTRINSIC
SCAN	118	230	1.7e-80	SMART
ZnF_C2H2	359	381	3.95e-4	SMART
ZnF_C2H2	387	409	4.87e-4	SMART
ZnF_C2H2	415	436	1.26e1	SMART
ZnF_C2H2	442	464	4.3e-5	SMART
ZnF_C2H2	470	492	3.95e-4	SMART
ZnF_C2H2	498	520	1.38e-3	SMART
ZnF_C2H2	526	548	2.2e-2	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000110961
AA Change: S278*

SMART Domains

Protein: ENSMUSP00000106586
Gene: ENSMUSG00000037017
AA Change: S278*

Domain	Start	End	E-Value	Type
low complexity region	28	37	N/A	INTRINSIC
SCAN	118	230	1.7e-80	SMART
ZnF_C2H2	359	381	3.95e-4	SMART
ZnF_C2H2	387	409	4.87e-4	SMART
ZnF_C2H2	415	436	1.26e1	SMART
ZnF_C2H2	442	464	4.3e-5	SMART
ZnF_C2H2	470	492	3.95e-4	SMART
ZnF_C2H2	498	520	1.38e-3	SMART
ZnF_C2H2	526	548	2.2e-2	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000142185
AA Change: S99*

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygotes for a targeted null mutation appear to be phenotypically normal. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 13 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsm1	A	G	7: 119,257,524 (GRCm39)	N403S	possibly damaging	Het
Adam32	T	C	8: 25,411,370 (GRCm39)	Y92C	probably damaging	Het
Ankfy1	G	A	11: 72,619,598 (GRCm39)	G157D	probably benign	Het
Cfap299	T	C	5: 98,932,369 (GRCm39)	Y190H	probably benign	Het
Champ1	T	C	8: 13,929,509 (GRCm39)	S556P	probably damaging	Het
Dnah8	T	G	17: 30,986,880 (GRCm39)	Y3176*	probably null	Het
Gbp8	T	C	5: 105,165,711 (GRCm39)	N314S	probably damaging	Het
Kif1c	A	G	11: 70,614,960 (GRCm39)		probably null	Het
Pcdhb22	T	C	18: 37,652,795 (GRCm39)	V421A	probably benign	Het
Plag1	A	G	4: 3,904,055 (GRCm39)	S379P	probably damaging	Het
Skint11	A	T	4: 114,051,889 (GRCm39)	D79V	probably damaging	Het
Tdp2	A	G	13: 25,024,521 (GRCm39)	T273A	probably damaging	Het
Utrn	A	G	10: 12,620,974 (GRCm39)		probably null	Het

Other mutations in Zscan21

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02348:Zscan21	APN	5	138,131,645 (GRCm39)	missense	probably damaging	0.99
IGL03295:Zscan21	APN	5	138,123,540 (GRCm39)	missense	possibly damaging	0.85
R0454:Zscan21	UTSW	5	138,131,865 (GRCm39)	missense	possibly damaging	0.77
R0471:Zscan21	UTSW	5	138,123,402 (GRCm39)	missense	probably benign	0.33
R1465:Zscan21	UTSW	5	138,123,470 (GRCm39)	missense	probably benign	0.18
R1465:Zscan21	UTSW	5	138,123,470 (GRCm39)	missense	probably benign	0.18
R1860:Zscan21	UTSW	5	138,124,892 (GRCm39)	missense	probably benign	0.00
R5498:Zscan21	UTSW	5	138,131,522 (GRCm39)	missense	probably benign
R5851:Zscan21	UTSW	5	138,124,740 (GRCm39)	missense	probably benign	0.39
R6213:Zscan21	UTSW	5	138,123,359 (GRCm39)	missense	probably benign	0.09
R7079:Zscan21	UTSW	5	138,124,728 (GRCm39)	missense	probably benign	0.11
R7448:Zscan21	UTSW	5	138,116,110 (GRCm39)	start gained	probably benign
R8436:Zscan21	UTSW	5	138,116,178 (GRCm39)	missense	unknown
R9116:Zscan21	UTSW	5	138,123,937 (GRCm39)	missense	probably damaging	0.99

Posted On

2012-12-06