Mutagenetix > Incidental Mutations

Incidental Mutation 'R0077:Vmn2r73'

150639

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r73

Ensembl Gene

ENSMUSG00000070458

Gene Name

vomeronasal 2, receptor 73

Synonyms

EG620928

MMRRC Submission

038364-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.180) question?

Stock #

R0077 (G1)

Quality Score

141

Status

Validated

Chromosome

Chromosomal Location

85857547-85875938 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 85875867 bp

Zygosity

Heterozygous

Amino Acid Change

Arginine to Serine at position 24 (R24S)

Ref Sequence

ENSEMBL: ENSMUSP00000076687 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077478]

Predicted Effect

probably benign
Transcript: ENSMUST00000077478
AA Change: R24S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000076687
Gene: ENSMUSG00000070458
AA Change: R24S

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	465	1.4e-30	PFAM
Pfam:NCD3G	508	560	5.9e-21	PFAM
Pfam:7tm_3	590	827	4.4e-51	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 98.9%
3x: 97.9%
10x: 95.4%
20x: 90.5%

Validation Efficiency

83% (159/192)

Allele List at MGI

Other mutations in this stock

Total: 73 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrl3	T	C	5: 81,771,685		probably benign	Het
Adgrl4	A	G	3: 151,517,781	I624V	probably damaging	Het
AI661453	A	G	17: 47,469,362		probably benign	Het
Alg12	C	T	15: 88,815,978	E60K	probably damaging	Het
Angel2	A	T	1: 190,933,087	N72Y	possibly damaging	Het
Ank1	C	A	8: 23,140,167	P81Q	probably damaging	Het
Atp6v1c2	A	T	12: 17,321,612	D61E	probably damaging	Het
Bpi	T	A	2: 158,261,334	M83K	probably damaging	Het
Capn7	A	G	14: 31,368,115	I642V	probably benign	Het
Ccdc134	T	C	15: 82,131,737		probably benign	Het
Ccr3	C	T	9: 124,029,024	T132I	probably damaging	Het
Cfap65	C	A	1: 74,931,918	W80C	probably damaging	Het
Chaf1a	T	A	17: 56,047,384	I218K	unknown	Het
Ddx23	A	G	15: 98,656,600		probably null	Het
Dmkn	A	G	7: 30,765,294	S231G	probably benign	Het
Ep300	T	C	15: 81,641,313	I1446T	unknown	Het
Fmnl1	T	C	11: 103,189,969	F318S	probably damaging	Het
Grik5	A	T	7: 25,023,380	V497E	probably damaging	Het
Gtf2ird2	T	C	5: 134,214,083	Y380H	probably damaging	Het
Hecw2	C	T	1: 53,868,831		probably benign	Het
Hspb7	A	G	4: 141,424,047	I167V	probably damaging	Het
Kcnh2	T	A	5: 24,322,702	N884I	probably benign	Het
Krba1	T	C	6: 48,405,225		probably benign	Het
Krt18	G	T	15: 102,030,974	R294L	probably benign	Het
Lctl	T	A	9: 64,122,107	M1K	probably null	Het
Lingo2	G	A	4: 35,708,375	S535F	possibly damaging	Het
Lrba	A	C	3: 86,542,688	N2105H	probably damaging	Het
Lrrc10	A	G	10: 117,045,514	D31G	probably damaging	Het
Lrrtm1	T	A	6: 77,243,872	V104E	probably damaging	Het
Mgat3	C	T	15: 80,212,577	T535I	probably benign	Het
Nav3	T	C	10: 109,716,642	I1780V	possibly damaging	Het
Nlrc4	A	G	17: 74,446,831	W186R	probably damaging	Het
Nr2c1	T	A	10: 94,188,255	F441I	probably benign	Het
Obscn	A	G	11: 59,051,521		probably benign	Het
Olfr221	T	C	14: 52,035,985	N42S	possibly damaging	Het
Olfr444	T	C	6: 42,955,773	S92P	probably benign	Het
Olfr59	T	C	11: 74,288,675	F10L	probably benign	Het
Olfr688	T	C	7: 105,288,519	V142A	probably damaging	Het
Osr1	A	T	12: 9,579,691	Y188F	probably damaging	Het
Pak2	A	T	16: 32,033,843	N293K	possibly damaging	Het
Pappa	A	T	4: 65,307,812	T1301S	probably damaging	Het
Pde4dip	G	A	3: 97,753,126	Q679*	probably null	Het
Pik3r5	T	A	11: 68,486,622		probably null	Het
Plbd2	C	T	5: 120,486,039		probably null	Het
Ppp1r3a	G	T	6: 14,754,517	P244T	possibly damaging	Het
Pum1	C	A	4: 130,772,674	R960S	probably benign	Het
Ralgapb	T	C	2: 158,473,249	Y845H	probably damaging	Het
Rbms1	A	T	2: 60,758,835	M287K	possibly damaging	Het
Rdh1	A	T	10: 127,760,037	I34F	probably damaging	Het
Rgl3	T	A	9: 21,974,102	Q644L	probably benign	Het
Rpap2	T	C	5: 107,620,474	S393P	probably damaging	Het
Rsad2	T	C	12: 26,456,377	S15G	probably damaging	Het
Rspo1	G	A	4: 124,991,397	R22Q	probably benign	Het
S100a11	A	C	3: 93,524,202		probably null	Het
Sept4	T	C	11: 87,581,196	S11P	probably benign	Het
Serpina1c	T	C	12: 103,896,091	S322G	probably benign	Het
Setdb1	A	T	3: 95,341,451	C385S	probably damaging	Het
Shank2	A	T	7: 144,192,467	I193F	possibly damaging	Het
Slc4a11	G	T	2: 130,686,301		probably benign	Het
Snrnp40	C	G	4: 130,378,043		probably null	Het
Tbcd	C	A	11: 121,594,274	Q761K	probably benign	Het
Tmed6	C	T	8: 107,065,566	V16M	probably damaging	Het
Tmem229a	T	C	6: 24,955,702	T18A	probably benign	Het
Tsc1	T	A	2: 28,678,943		probably benign	Het
Ube2m	T	C	7: 13,035,730	N49D	probably damaging	Het
Ubqlnl	T	C	7: 104,150,047	D81G	probably damaging	Het
Vmn2r56	A	G	7: 12,715,405	V302A	probably benign	Het
Wfs1	C	A	5: 36,973,194	S236I	probably damaging	Het
Xpot	A	T	10: 121,605,639	N560K	probably benign	Het
Yipf3	A	G	17: 46,251,577	T303A	probably benign	Het
Zfp790	T	C	7: 29,824,875	W19R	probably damaging	Het
Zfp846	T	C	9: 20,594,007	C388R	probably benign	Het
Zpr1	T	A	9: 46,273,336	I47N	probably damaging	Het

Other mutations in Vmn2r73

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00158:Vmn2r73	APN	7	85857587	missense	probably benign
IGL01151:Vmn2r73	APN	7	85857878	missense	probably damaging	0.99
IGL01408:Vmn2r73	APN	7	85872247	missense	probably benign	0.45
IGL01505:Vmn2r73	APN	7	85858059	nonsense	probably null
IGL01731:Vmn2r73	APN	7	85857549	makesense	probably null
IGL01818:Vmn2r73	APN	7	85869901	splice site	probably benign
IGL02236:Vmn2r73	APN	7	85872694	missense	probably benign	0.00
IGL02265:Vmn2r73	APN	7	85871639	missense	probably benign	0.02
IGL02266:Vmn2r73	APN	7	85875799	missense	possibly damaging	0.52
IGL02276:Vmn2r73	APN	7	85869772	critical splice donor site	probably null
IGL02284:Vmn2r73	APN	7	85857915	missense	possibly damaging	0.92
IGL02380:Vmn2r73	APN	7	85858175	missense	probably benign	0.00
IGL02466:Vmn2r73	APN	7	85872876	missense	probably damaging	1.00
IGL03172:Vmn2r73	APN	7	85858287	missense	probably benign	0.01
IGL03179:Vmn2r73	APN	7	85870260	missense	probably benign	0.04
R0311:Vmn2r73	UTSW	7	85871789	missense	probably benign
R0413:Vmn2r73	UTSW	7	85871879	missense	possibly damaging	0.68
R0494:Vmn2r73	UTSW	7	85872932	missense	probably benign
R1523:Vmn2r73	UTSW	7	85870278	missense	probably benign	0.02
R1618:Vmn2r73	UTSW	7	85875912	nonsense	probably null
R1667:Vmn2r73	UTSW	7	85857681	missense	probably benign	0.00
R1728:Vmn2r73	UTSW	7	85857878	missense	probably damaging	1.00
R1729:Vmn2r73	UTSW	7	85857878	missense	probably damaging	1.00
R1747:Vmn2r73	UTSW	7	85858167	missense	probably damaging	1.00
R1784:Vmn2r73	UTSW	7	85857878	missense	probably damaging	1.00
R2152:Vmn2r73	UTSW	7	85857728	missense	probably benign	0.03
R2395:Vmn2r73	UTSW	7	85857767	missense	probably damaging	1.00
R2415:Vmn2r73	UTSW	7	85872223	missense	probably damaging	1.00
R2926:Vmn2r73	UTSW	7	85871663	missense	probably benign	0.17
R3719:Vmn2r73	UTSW	7	85870374	missense	probably damaging	1.00
R3766:Vmn2r73	UTSW	7	85871990	missense	probably benign
R3838:Vmn2r73	UTSW	7	85858050	missense	probably benign	0.00
R3890:Vmn2r73	UTSW	7	85857936	missense	probably benign
R4030:Vmn2r73	UTSW	7	85871836	missense	possibly damaging	0.92
R4247:Vmn2r73	UTSW	7	85872675	missense	probably damaging	0.99
R4409:Vmn2r73	UTSW	7	85871560	missense	probably damaging	0.97
R4427:Vmn2r73	UTSW	7	85857773	missense	probably damaging	1.00
R4430:Vmn2r73	UTSW	7	85870241	missense	probably benign
R4552:Vmn2r73	UTSW	7	85875847	missense	probably benign	0.12
R4779:Vmn2r73	UTSW	7	85871715	nonsense	probably null
R4906:Vmn2r73	UTSW	7	85857621	missense	probably damaging	0.99
R4942:Vmn2r73	UTSW	7	85870374	missense	probably damaging	1.00
R5280:Vmn2r73	UTSW	7	85857947	missense	probably damaging	0.98
R5344:Vmn2r73	UTSW	7	85875838	missense	probably benign	0.00
R5478:Vmn2r73	UTSW	7	85869788	missense	probably damaging	1.00
R5527:Vmn2r73	UTSW	7	85858367	missense	possibly damaging	0.65
R5691:Vmn2r73	UTSW	7	85858091	missense	probably damaging	1.00
R5826:Vmn2r73	UTSW	7	85875748	missense	possibly damaging	0.77
R6018:Vmn2r73	UTSW	7	85872667	missense	possibly damaging	0.48
R6082:Vmn2r73	UTSW	7	85858221	missense	probably benign	0.00
R6111:Vmn2r73	UTSW	7	85871789	missense	probably benign
R6233:Vmn2r73	UTSW	7	85869891	missense	probably benign	0.00
R6278:Vmn2r73	UTSW	7	85872932	missense	probably benign
R6283:Vmn2r73	UTSW	7	85871841	missense	probably benign	0.00
R6307:Vmn2r73	UTSW	7	85857620	missense	probably damaging	1.00
R6413:Vmn2r73	UTSW	7	85870336	nonsense	probably null
R6782:Vmn2r73	UTSW	7	85870355	missense	probably benign	0.00
R6884:Vmn2r73	UTSW	7	85858005	missense	probably benign	0.05
R6921:Vmn2r73	UTSW	7	85858238	missense	probably benign	0.27
R7169:Vmn2r73	UTSW	7	85858455	nonsense	probably null
R7206:Vmn2r73	UTSW	7	85872867	missense	probably benign	0.03
R7311:Vmn2r73	UTSW	7	85871984	missense	possibly damaging	0.80
R7650:Vmn2r73	UTSW	7	85871939	missense	probably benign
R7811:Vmn2r73	UTSW	7	85875748	missense	possibly damaging	0.77
X0023:Vmn2r73	UTSW	7	85858456	missense	probably benign	0.31

Predicted Primers

PCR Primer
(F):5'- GGTATCCATGCTGACAGATGGAACATT -3'
(R):5'- TCATCCAGAGGCAAACAAGGAACTG -3'

Sequencing Primer
(F):5'- ACAGTGGGTCATTCATTCAGC -3'
(R):5'- GTAATAAATAGTGACACTTGCCTGG -3'

Posted On

2014-01-24