|Institutional Source||Beutler Lab|
|Gene Name||fos-like antigen 2|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||R1275 (G1)|
|Chromosomal Location||32135801-32157842 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||C to T at 32150454 bp|
|Amino Acid Change||Arginine to Tryptophan at position 130 (R130W)|
|Ref Sequence||ENSEMBL: ENSMUSP00000031017 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000031017]|
|Predicted Effect||probably damaging
AA Change: R130W
PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
AA Change: R130W
|Predicted Effect||noncoding transcript
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]
PHENOTYPE: Mice homozygous for disruptions in this gene die within one week after birth and show postnatal growth retardation. Further analysis of one allele showed abnormal cartilage development, with delayed bone ossification and impaired chondrocyte differentiation. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Fosl2||
(F):5'- AGCTGAGAGACAAATGCTGCCC -3'
(R):5'- TGACGTGAGAAAATGTACTGACCCG -3'
(F):5'- GACAAATGCTGCCCTGATG -3'
(R):5'- TCACACTCGTGGCAAAGG -3'