Incidental Mutation 'R1276:Mydgf'
ID 150914
Institutional Source Beutler Lab
Gene Symbol Mydgf
Ensembl Gene ENSMUSG00000019579
Gene Name myeloid derived growth factor
Synonyms D17Wsu104e
MMRRC Submission 039342-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # R1276 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 56483541-56490920 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 56486362 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000019723 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019723]
AlphaFold Q9CPT4
Predicted Effect probably null
Transcript: ENSMUST00000019723
SMART Domains Protein: ENSMUSP00000019723
Gene: ENSMUSG00000019579

DomainStartEndE-ValueType
Pfam:UPF0556 11 166 4.8e-82 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140885
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151093
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.3%
  • 10x: 96.2%
  • 20x: 92.4%
Validation Efficiency
MGI Phenotype FUNCTION: The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was identified in error as interleukin 25. This activity has not been reproducible, however, and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null mutation display normal cardiac and vascular development but develop larger myocardial infactions with reduced angiogenesis and increased scarring. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgra2 C A 8: 27,609,852 (GRCm39) A660D probably damaging Het
Ccdc82 A T 9: 13,281,903 (GRCm39) I443F probably benign Het
Cct4 C T 11: 22,952,171 (GRCm39) L391F probably damaging Het
Cep63 A T 9: 102,466,099 (GRCm39) D642E possibly damaging Het
Chd5 T A 4: 152,463,191 (GRCm39) L1424Q probably damaging Het
Cox4i1 A G 8: 121,400,089 (GRCm39) Y71C probably damaging Het
Cyp2c69 T A 19: 39,864,668 (GRCm39) Q270L possibly damaging Het
Egln2 TTGCTGCTGCTGCTGCTGCTG TTGCTGCTGCTGCTGCTG 7: 26,864,430 (GRCm39) probably benign Het
Fbln1 A G 15: 85,113,791 (GRCm39) D175G probably damaging Het
Fbxw15 G A 9: 109,387,314 (GRCm39) S227F probably damaging Het
Gm9847 A G 12: 14,544,932 (GRCm39) noncoding transcript Het
Hdlbp A T 1: 93,348,823 (GRCm39) S576T probably benign Het
Hmgxb3 T C 18: 61,298,576 (GRCm39) N296S probably benign Het
Lrba T A 3: 86,571,833 (GRCm39) V2379E probably damaging Het
Lrp1b A T 2: 41,618,588 (GRCm39) I162N probably benign Het
Sh3pxd2a T C 19: 47,256,822 (GRCm39) D632G probably benign Het
Ska3 T C 14: 58,057,726 (GRCm39) M209V probably damaging Het
Slc4a10 A G 2: 62,080,787 (GRCm39) E308G probably damaging Het
Srsf4 C T 4: 131,624,996 (GRCm39) T131M probably damaging Het
Suco A T 1: 161,685,025 (GRCm39) S156T probably benign Het
Svs5 T A 2: 164,079,168 (GRCm39) Q246H possibly damaging Het
Syne2 A G 12: 75,987,963 (GRCm39) probably null Het
Tbc1d9b T A 11: 50,043,476 (GRCm39) H532Q possibly damaging Het
Tcf21 G A 10: 22,695,489 (GRCm39) T105I probably damaging Het
Thsd7a C A 6: 12,418,369 (GRCm39) C620F probably damaging Het
Vmn1r194 A G 13: 22,429,031 (GRCm39) Y216C probably damaging Het
Vmn2r94 T C 17: 18,477,344 (GRCm39) S356G possibly damaging Het
Wasf1 T A 10: 40,812,522 (GRCm39) I437N unknown Het
Wdr24 A G 17: 26,046,441 (GRCm39) Y538C probably benign Het
Zbtb4 G T 11: 69,667,045 (GRCm39) D117Y probably damaging Het
Zfp654 A T 16: 64,605,699 (GRCm39) F293L probably damaging Het
Zkscan7 A G 9: 122,719,788 (GRCm39) E158G probably damaging Het
Other mutations in Mydgf
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00953:Mydgf APN 17 56,486,407 (GRCm39) missense probably damaging 0.99
R1616:Mydgf UTSW 17 56,486,415 (GRCm39) missense possibly damaging 0.92
R4919:Mydgf UTSW 17 56,483,953 (GRCm39) missense probably damaging 1.00
R5784:Mydgf UTSW 17 56,485,254 (GRCm39) unclassified probably benign
R6863:Mydgf UTSW 17 56,490,789 (GRCm39) missense probably damaging 0.99
R6939:Mydgf UTSW 17 56,490,737 (GRCm39) critical splice donor site probably null
R8520:Mydgf UTSW 17 56,490,734 (GRCm39) splice site probably null
Predicted Primers PCR Primer
(F):5'- AGCCTACTTGTCCTGCATGGACTG -3'
(R):5'- TTTAGACAGGGTCTTAACTGTTGCCAC -3'

Sequencing Primer
(F):5'- CCTGCATGGACTGTGGTG -3'
(R):5'- AAGTGACTGGATAGTGCCCTC -3'
Posted On 2014-01-29