Incidental Mutation 'R1278:Ly6g6d'
ID 150960
Institutional Source Beutler Lab
Gene Symbol Ly6g6d
Ensembl Gene ENSMUSG00000073413
Gene Name lymphocyte antigen 6 family member G6D
Synonyms G6d, NG25, MEGT1, G6f, A930024F17Rik, NG32
MMRRC Submission 039344-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1278 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 35290419-35297041 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 35290636 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Leucine at position 98 (Q98L)
Ref Sequence ENSEMBL: ENSMUSP00000007259 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000007259] [ENSMUST00000173207] [ENSMUST00000174876] [ENSMUST00000173478]
AlphaFold Q9Z1Q3
Predicted Effect probably benign
Transcript: ENSMUST00000007259
AA Change: Q98L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000007259
Gene: ENSMUSG00000073413
AA Change: Q98L

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
low complexity region 121 132 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000172639
Predicted Effect noncoding transcript
Transcript: ENSMUST00000172745
Predicted Effect noncoding transcript
Transcript: ENSMUST00000172903
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173120
Predicted Effect probably benign
Transcript: ENSMUST00000173207
SMART Domains Protein: ENSMUSP00000134194
Gene: ENSMUSG00000092586

DomainStartEndE-ValueType
low complexity region 22 39 N/A INTRINSIC
Blast:LU 48 136 3e-57 BLAST
low complexity region 139 151 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000174876
SMART Domains Protein: ENSMUSP00000133838
Gene: ENSMUSG00000092586

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Blast:LU 22 56 9e-18 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000173478
SMART Domains Protein: ENSMUSP00000133510
Gene: ENSMUSG00000092586

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Blast:LU 22 110 2e-57 BLAST
low complexity region 113 125 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 91.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] LY6G6D belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Apr 2009]
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 A G 6: 128,535,470 (GRCm39) S747P probably damaging Het
Adgb A G 10: 10,258,572 (GRCm39) Y1063H probably damaging Het
Cacna1d A G 14: 29,900,660 (GRCm39) S320P probably damaging Het
Ccdc171 C T 4: 83,580,095 (GRCm39) A622V possibly damaging Het
Cul9 TTCCTCCTCCTCCTCCTCCTCCTC TTCCTCCTCCTCCTCCTCCTC 17: 46,811,775 (GRCm39) probably benign Het
Dmxl1 T C 18: 50,026,292 (GRCm39) V1800A probably benign Het
Dock5 T C 14: 68,077,015 (GRCm39) N276S possibly damaging Het
Fat2 T C 11: 55,159,005 (GRCm39) E3389G probably damaging Het
Gnb4 T C 3: 32,641,886 (GRCm39) D247G probably damaging Het
Kif20a C T 18: 34,759,830 (GRCm39) T75I probably benign Het
Lcor A G 19: 41,573,122 (GRCm39) T626A probably benign Het
Lix1 A G 17: 17,647,469 (GRCm39) K45R probably benign Het
Mark4 T A 7: 19,165,695 (GRCm39) S533C probably damaging Het
Myo1e T A 9: 70,306,067 (GRCm39) V1104D probably damaging Het
Naip6 T C 13: 100,436,870 (GRCm39) D551G probably damaging Het
Or5k14 G T 16: 58,693,340 (GRCm39) P58T probably damaging Het
Pla2g4e A G 2: 119,998,951 (GRCm39) probably null Het
Ror1 T C 4: 100,299,075 (GRCm39) F816S possibly damaging Het
Rsf1 ATGGCG ATGGCGACGGTGGCG 7: 97,229,111 (GRCm39) probably benign Het
Secisbp2 G T 13: 51,808,546 (GRCm39) V104F probably damaging Het
Trpa1 A G 1: 14,988,947 (GRCm39) probably null Het
Trpm7 A T 2: 126,667,374 (GRCm39) Y846* probably null Het
Other mutations in Ly6g6d
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01462:Ly6g6d APN 17 35,293,226 (GRCm39) missense probably benign 0.04
R0668:Ly6g6d UTSW 17 35,290,715 (GRCm39) missense probably damaging 0.98
R1891:Ly6g6d UTSW 17 35,293,269 (GRCm39) nonsense probably null
R4029:Ly6g6d UTSW 17 35,290,636 (GRCm39) missense probably benign 0.00
R4960:Ly6g6d UTSW 17 35,290,730 (GRCm39) missense probably benign 0.01
R5125:Ly6g6d UTSW 17 35,293,418 (GRCm39) missense possibly damaging 0.83
Predicted Primers PCR Primer
(F):5'- ACGGCACACAAGGGAGTGTTTG -3'
(R):5'- TCCTGGAACATCCTAGCATCCCTG -3'

Sequencing Primer
(F):5'- CACAAGGGAGTGTTTGTCTTCTTAC -3'
(R):5'- AGGACAGAGTATCCTTTCTGAGC -3'
Posted On 2014-01-29