Incidental Mutation 'R1279:Vmn1r7'
| ID |
150971 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r7
|
| Ensembl Gene |
ENSMUSG00000093696 |
| Gene Name |
vomeronasal 1 receptor 7 |
| Synonyms |
V1rc31, Gm5568 |
| MMRRC Submission |
039345-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.129)
|
| Stock # |
R1279 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
57001323-57002258 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 57001934 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 109
(T109A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135571
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000176252]
|
| AlphaFold |
E9Q8T0 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000176252
AA Change: T109A
PolyPhen 2
Score 0.633 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000135571
Gene: ENSMUSG00000093696
AA Change: T109A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
1.1e-59 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.8%
- 20x: 94.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 23 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Akap8l |
C |
T |
17: 32,551,457 (GRCm39) |
R511H |
probably damaging |
Het |
| Atp6v0d2 |
A |
T |
4: 19,878,298 (GRCm39) |
M325K |
probably benign |
Het |
| Bltp3a |
T |
C |
17: 28,109,045 (GRCm39) |
F1088S |
possibly damaging |
Het |
| Gjb3 |
G |
A |
4: 127,220,224 (GRCm39) |
R103W |
probably damaging |
Het |
| Gm17305 |
TCTCCTCCTCCTCCTCCTCCTC |
TCTCCTCCTCCTCCTCCTC |
11: 69,260,175 (GRCm39) |
|
probably benign |
Het |
| Mfap5 |
A |
G |
6: 122,503,722 (GRCm39) |
|
probably null |
Het |
| Nrcam |
T |
C |
12: 44,591,660 (GRCm39) |
|
probably null |
Het |
| Oas1a |
A |
G |
5: 121,035,241 (GRCm39) |
|
probably null |
Het |
| Oat |
A |
T |
7: 132,168,809 (GRCm39) |
L137H |
probably damaging |
Het |
| Or10h5 |
T |
C |
17: 33,435,300 (GRCm39) |
Y6C |
possibly damaging |
Het |
| Or2n1c |
A |
G |
17: 38,519,678 (GRCm39) |
I181V |
probably benign |
Het |
| Or5h17 |
G |
A |
16: 58,820,501 (GRCm39) |
G151D |
possibly damaging |
Het |
| Padi3 |
T |
C |
4: 140,530,888 (GRCm39) |
S45G |
probably benign |
Het |
| Pias1 |
A |
G |
9: 62,799,427 (GRCm39) |
S488P |
probably damaging |
Het |
| Plxnb2 |
G |
A |
15: 89,046,524 (GRCm39) |
T873I |
probably benign |
Het |
| Ppp4r2 |
A |
T |
6: 100,842,879 (GRCm39) |
R176* |
probably null |
Het |
| Pramel51 |
C |
T |
12: 88,142,650 (GRCm39) |
V323M |
probably benign |
Het |
| Prkdc |
A |
T |
16: 15,508,146 (GRCm39) |
L932F |
probably damaging |
Het |
| Ros1 |
C |
A |
10: 52,018,262 (GRCm39) |
A799S |
possibly damaging |
Het |
| Scn4a |
A |
T |
11: 106,226,508 (GRCm39) |
I684N |
probably damaging |
Het |
| Sypl2 |
A |
G |
3: 108,124,990 (GRCm39) |
F124L |
probably damaging |
Het |
| Tacr1 |
G |
T |
6: 82,534,164 (GRCm39) |
E397* |
probably null |
Het |
| Zp1 |
A |
G |
19: 10,895,941 (GRCm39) |
S232P |
probably damaging |
Het |
|
| Other mutations in Vmn1r7 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01382:Vmn1r7
|
APN |
6 |
57,001,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01528:Vmn1r7
|
APN |
6 |
57,001,532 (GRCm39) |
missense |
probably benign |
|
|
IGL02024:Vmn1r7
|
APN |
6 |
57,001,874 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02234:Vmn1r7
|
APN |
6 |
57,001,537 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02610:Vmn1r7
|
APN |
6 |
57,002,037 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02691:Vmn1r7
|
APN |
6 |
57,001,373 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0529:Vmn1r7
|
UTSW |
6 |
57,001,450 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0548:Vmn1r7
|
UTSW |
6 |
57,002,066 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1254:Vmn1r7
|
UTSW |
6 |
57,001,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1582:Vmn1r7
|
UTSW |
6 |
57,002,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1973:Vmn1r7
|
UTSW |
6 |
57,002,011 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1991:Vmn1r7
|
UTSW |
6 |
57,001,853 (GRCm39) |
missense |
probably benign |
0.37 |
|
R2160:Vmn1r7
|
UTSW |
6 |
57,001,879 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3546:Vmn1r7
|
UTSW |
6 |
57,001,834 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3547:Vmn1r7
|
UTSW |
6 |
57,001,834 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5901:Vmn1r7
|
UTSW |
6 |
57,001,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6294:Vmn1r7
|
UTSW |
6 |
57,001,404 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7063:Vmn1r7
|
UTSW |
6 |
57,001,418 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R7192:Vmn1r7
|
UTSW |
6 |
57,001,452 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7647:Vmn1r7
|
UTSW |
6 |
57,002,255 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7781:Vmn1r7
|
UTSW |
6 |
57,001,553 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9457:Vmn1r7
|
UTSW |
6 |
57,001,508 (GRCm39) |
missense |
probably damaging |
0.97 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCATTGCCTCTGATGCCTGAAC -3'
(R):5'- AGACCTGATCTCCTGTCAACTGTCC -3'
Sequencing Primer
(F):5'- ACACTTGTAGTCAGCATGACTC -3'
(R):5'- CAACTGTCCTTTGTTCACATAATGG -3'
|
| Posted On |
2014-01-29 |
Incidental Mutation