Incidental Mutation 'R1279:Or10h5'
ID 150988
Institutional Source Beutler Lab
Gene Symbol Or10h5
Ensembl Gene ENSMUSG00000096169
Gene Name olfactory receptor family 10 subfamily H member 5
Synonyms Olfr1564, Gm4461
MMRRC Submission 039345-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.156) question?
Stock # R1279 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 33434235-33435325 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 33435300 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 6 (Y6C)
Ref Sequence ENSEMBL: ENSMUSP00000150573 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000112162] [ENSMUST00000208645] [ENSMUST00000213642] [ENSMUST00000213751] [ENSMUST00000215450]
AlphaFold K7N6V7
Predicted Effect possibly damaging
Transcript: ENSMUST00000112162
AA Change: Y9C

PolyPhen 2 Score 0.586 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000127247
Gene: ENSMUSG00000096169
AA Change: Y9C

DomainStartEndE-ValueType
Pfam:7tm_4 34 312 3.3e-53 PFAM
Pfam:7TM_GPCR_Srsx 38 263 1.5e-5 PFAM
Pfam:7tm_1 44 297 5e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000208645
AA Change: Y6C

PolyPhen 2 Score 0.586 (Sensitivity: 0.88; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000213642
AA Change: Y6C

PolyPhen 2 Score 0.586 (Sensitivity: 0.88; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000213751
AA Change: Y6C

PolyPhen 2 Score 0.586 (Sensitivity: 0.88; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215450
AA Change: Y6C

PolyPhen 2 Score 0.586 (Sensitivity: 0.88; Specificity: 0.91)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.8%
  • 20x: 94.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Nov 2010]
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap8l C T 17: 32,551,457 (GRCm39) R511H probably damaging Het
Atp6v0d2 A T 4: 19,878,298 (GRCm39) M325K probably benign Het
Bltp3a T C 17: 28,109,045 (GRCm39) F1088S possibly damaging Het
Gjb3 G A 4: 127,220,224 (GRCm39) R103W probably damaging Het
Gm17305 TCTCCTCCTCCTCCTCCTCCTC TCTCCTCCTCCTCCTCCTC 11: 69,260,175 (GRCm39) probably benign Het
Mfap5 A G 6: 122,503,722 (GRCm39) probably null Het
Nrcam T C 12: 44,591,660 (GRCm39) probably null Het
Oas1a A G 5: 121,035,241 (GRCm39) probably null Het
Oat A T 7: 132,168,809 (GRCm39) L137H probably damaging Het
Or2n1c A G 17: 38,519,678 (GRCm39) I181V probably benign Het
Or5h17 G A 16: 58,820,501 (GRCm39) G151D possibly damaging Het
Padi3 T C 4: 140,530,888 (GRCm39) S45G probably benign Het
Pias1 A G 9: 62,799,427 (GRCm39) S488P probably damaging Het
Plxnb2 G A 15: 89,046,524 (GRCm39) T873I probably benign Het
Ppp4r2 A T 6: 100,842,879 (GRCm39) R176* probably null Het
Pramel51 C T 12: 88,142,650 (GRCm39) V323M probably benign Het
Prkdc A T 16: 15,508,146 (GRCm39) L932F probably damaging Het
Ros1 C A 10: 52,018,262 (GRCm39) A799S possibly damaging Het
Scn4a A T 11: 106,226,508 (GRCm39) I684N probably damaging Het
Sypl2 A G 3: 108,124,990 (GRCm39) F124L probably damaging Het
Tacr1 G T 6: 82,534,164 (GRCm39) E397* probably null Het
Vmn1r7 T C 6: 57,001,934 (GRCm39) T109A possibly damaging Het
Zp1 A G 19: 10,895,941 (GRCm39) S232P probably damaging Het
Other mutations in Or10h5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00965:Or10h5 APN 17 33,434,947 (GRCm39) missense probably benign 0.41
R0079:Or10h5 UTSW 17 33,435,079 (GRCm39) missense probably benign 0.14
R0939:Or10h5 UTSW 17 33,434,635 (GRCm39) missense possibly damaging 0.72
R2167:Or10h5 UTSW 17 33,434,542 (GRCm39) missense probably damaging 0.97
R2866:Or10h5 UTSW 17 33,435,252 (GRCm39) missense probably benign 0.22
R4738:Or10h5 UTSW 17 33,434,784 (GRCm39) missense probably benign 0.03
R4976:Or10h5 UTSW 17 33,434,728 (GRCm39) missense probably benign 0.35
R6452:Or10h5 UTSW 17 33,434,919 (GRCm39) missense probably benign 0.03
R6721:Or10h5 UTSW 17 33,434,508 (GRCm39) missense probably benign
R7322:Or10h5 UTSW 17 33,434,673 (GRCm39) missense probably damaging 1.00
R8032:Or10h5 UTSW 17 33,434,924 (GRCm39) missense possibly damaging 0.85
R8470:Or10h5 UTSW 17 33,434,868 (GRCm39) missense probably benign 0.00
R9560:Or10h5 UTSW 17 33,434,986 (GRCm39) missense probably damaging 1.00
R9562:Or10h5 UTSW 17 33,434,415 (GRCm39) missense probably benign 0.06
R9753:Or10h5 UTSW 17 33,434,688 (GRCm39) missense possibly damaging 0.60
Predicted Primers PCR Primer
(F):5'- TCATAGCCCATGACGGTGAGTAGAA -3'
(R):5'- TGCATGGTGGTGAGACCTGAGA -3'

Sequencing Primer
(F):5'- AGGTCAGCCAACATGCG -3'
(R):5'- CCTGAGAAAGTTAAAGAAGCCTC -3'
Posted On 2014-01-29