Incidental Mutation 'R1281:Nox3'
ID |
151038 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Nox3
|
Ensembl Gene |
ENSMUSG00000023802 |
Gene Name |
NADPH oxidase 3 |
Synonyms |
het, nmf250 |
MMRRC Submission |
039347-MU
|
Accession Numbers |
|
Essential gene? |
Possibly non essential
(E-score: 0.338)
|
Stock # |
R1281 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
17 |
Chromosomal Location |
3685515-3746536 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 3746460 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Asparagine
at position 26
(I26N)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000115800]
|
AlphaFold |
Q672J9 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000024565
AA Change: I26N
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
SMART Domains |
Protein: ENSMUSP00000024565 Gene: ENSMUSG00000023802 AA Change: I26N
Domain | Start | End | E-Value | Type |
transmembrane domain
|
33 |
55 |
N/A |
INTRINSIC |
Pfam:Ferric_reduct
|
75 |
238 |
8.6e-28 |
PFAM |
Pfam:FAD_binding_8
|
311 |
413 |
4.1e-26 |
PFAM |
Pfam:NAD_binding_6
|
419 |
569 |
1e-33 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000115800
AA Change: I6N
PolyPhen 2
Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000111466 Gene: ENSMUSG00000023802 AA Change: I6N
Domain | Start | End | E-Value | Type |
transmembrane domain
|
13 |
35 |
N/A |
INTRINSIC |
Pfam:Ferric_reduct
|
55 |
218 |
5.4e-23 |
PFAM |
Pfam:FAD_binding_6
|
290 |
379 |
1.8e-8 |
PFAM |
Pfam:FAD_binding_8
|
291 |
393 |
1.5e-27 |
PFAM |
Pfam:NAD_binding_6
|
399 |
549 |
1e-34 |
PFAM |
|
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.2%
- 20x: 92.4%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: This gene encodes a member of the NOX family of NADPH oxidases. These enzymes catalyze the transfer of electrons from NADPH to molecular oxygen to produce superoxide and other reactive oxygen species (ROS). The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia, which are crystalline structures of the inner ear involved in the perception of gravity and linear acceleration. In mouse mutations of this gene lead to the absence of otoconia and vestibular dysfunction. [provided by RefSeq, Jun 2013] PHENOTYPE: Homozygous mutants bilaterally lack otoliths in otherwise normal ears and display impaired swimming ability, motor capabilities, and vestibular responses. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 25 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aim2 |
A |
T |
1: 173,287,377 (GRCm39) |
K126* |
probably null |
Het |
C9 |
A |
T |
15: 6,519,321 (GRCm39) |
N386I |
possibly damaging |
Het |
Csnk1e |
A |
C |
15: 79,304,841 (GRCm39) |
N387K |
possibly damaging |
Het |
Cul9 |
T |
C |
17: 46,822,460 (GRCm39) |
T1758A |
probably damaging |
Het |
Dcaf17 |
A |
G |
2: 70,908,500 (GRCm39) |
I256V |
probably damaging |
Het |
Duox1 |
G |
A |
2: 122,157,569 (GRCm39) |
C565Y |
probably damaging |
Het |
Fchsd2 |
A |
G |
7: 100,902,759 (GRCm39) |
H379R |
possibly damaging |
Het |
Gjb3 |
G |
A |
4: 127,220,224 (GRCm39) |
R103W |
probably damaging |
Het |
Krt1c |
C |
A |
15: 101,721,727 (GRCm39) |
C438F |
probably damaging |
Het |
Mast4 |
G |
A |
13: 102,887,086 (GRCm39) |
T1001I |
probably damaging |
Het |
Mrc1 |
T |
C |
2: 14,298,321 (GRCm39) |
F726L |
probably damaging |
Het |
Mroh2a |
T |
TN |
1: 88,183,889 (GRCm39) |
|
probably null |
Het |
Mttp |
T |
C |
3: 137,812,980 (GRCm39) |
N550S |
possibly damaging |
Het |
Necap1 |
G |
T |
6: 122,851,573 (GRCm39) |
D16Y |
possibly damaging |
Het |
Patj |
T |
C |
4: 98,304,932 (GRCm39) |
I262T |
probably damaging |
Het |
Pcdh8 |
T |
C |
14: 80,005,166 (GRCm39) |
E953G |
probably damaging |
Het |
Pirb |
A |
T |
7: 3,720,189 (GRCm39) |
C395S |
probably damaging |
Het |
Sacs |
A |
G |
14: 61,429,250 (GRCm39) |
I433M |
probably benign |
Het |
Sclt1 |
A |
G |
3: 41,602,055 (GRCm39) |
F552L |
probably benign |
Het |
Smc5 |
T |
C |
19: 23,213,247 (GRCm39) |
N479S |
probably benign |
Het |
Tg |
G |
A |
15: 66,568,338 (GRCm39) |
V1342I |
probably benign |
Het |
Ube2n |
C |
A |
10: 95,377,618 (GRCm39) |
N132K |
probably benign |
Het |
Vmn2r55 |
A |
T |
7: 12,404,825 (GRCm39) |
C193S |
probably benign |
Het |
Zc3hav1 |
A |
G |
6: 38,330,872 (GRCm39) |
C96R |
probably damaging |
Het |
Zfp60 |
T |
A |
7: 27,437,852 (GRCm39) |
V53E |
probably damaging |
Het |
|
Other mutations in Nox3 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01024:Nox3
|
APN |
17 |
3,733,290 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01135:Nox3
|
APN |
17 |
3,746,527 (GRCm39) |
utr 5 prime |
probably benign |
|
IGL01791:Nox3
|
APN |
17 |
3,733,218 (GRCm39) |
missense |
possibly damaging |
0.68 |
IGL02423:Nox3
|
APN |
17 |
3,733,191 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03091:Nox3
|
APN |
17 |
3,716,119 (GRCm39) |
missense |
probably benign |
0.42 |
R0046:Nox3
|
UTSW |
17 |
3,733,236 (GRCm39) |
missense |
probably benign |
0.08 |
R0046:Nox3
|
UTSW |
17 |
3,733,236 (GRCm39) |
missense |
probably benign |
0.08 |
R0085:Nox3
|
UTSW |
17 |
3,685,556 (GRCm39) |
missense |
probably benign |
0.14 |
R0426:Nox3
|
UTSW |
17 |
3,745,838 (GRCm39) |
missense |
probably damaging |
1.00 |
R0690:Nox3
|
UTSW |
17 |
3,745,839 (GRCm39) |
missense |
probably damaging |
1.00 |
R1350:Nox3
|
UTSW |
17 |
3,700,396 (GRCm39) |
missense |
probably damaging |
1.00 |
R1843:Nox3
|
UTSW |
17 |
3,720,153 (GRCm39) |
missense |
probably damaging |
1.00 |
R1902:Nox3
|
UTSW |
17 |
3,720,292 (GRCm39) |
missense |
probably damaging |
1.00 |
R2023:Nox3
|
UTSW |
17 |
3,744,296 (GRCm39) |
splice site |
probably benign |
|
R2762:Nox3
|
UTSW |
17 |
3,746,433 (GRCm39) |
missense |
probably benign |
0.35 |
R2872:Nox3
|
UTSW |
17 |
3,733,191 (GRCm39) |
missense |
probably damaging |
1.00 |
R2872:Nox3
|
UTSW |
17 |
3,733,191 (GRCm39) |
missense |
probably damaging |
1.00 |
R4429:Nox3
|
UTSW |
17 |
3,733,233 (GRCm39) |
missense |
probably benign |
0.05 |
R4630:Nox3
|
UTSW |
17 |
3,744,257 (GRCm39) |
missense |
possibly damaging |
0.53 |
R4926:Nox3
|
UTSW |
17 |
3,720,169 (GRCm39) |
missense |
probably damaging |
1.00 |
R4928:Nox3
|
UTSW |
17 |
3,685,550 (GRCm39) |
missense |
probably null |
1.00 |
R5181:Nox3
|
UTSW |
17 |
3,685,561 (GRCm39) |
nonsense |
probably null |
|
R6911:Nox3
|
UTSW |
17 |
3,736,198 (GRCm39) |
missense |
probably damaging |
1.00 |
R6912:Nox3
|
UTSW |
17 |
3,736,198 (GRCm39) |
missense |
probably damaging |
1.00 |
R7486:Nox3
|
UTSW |
17 |
3,720,219 (GRCm39) |
missense |
probably damaging |
1.00 |
R7529:Nox3
|
UTSW |
17 |
3,722,050 (GRCm39) |
missense |
probably damaging |
0.99 |
R8355:Nox3
|
UTSW |
17 |
3,736,198 (GRCm39) |
missense |
probably damaging |
1.00 |
R8357:Nox3
|
UTSW |
17 |
3,736,198 (GRCm39) |
missense |
probably damaging |
1.00 |
R8455:Nox3
|
UTSW |
17 |
3,736,198 (GRCm39) |
missense |
probably damaging |
1.00 |
R8457:Nox3
|
UTSW |
17 |
3,736,198 (GRCm39) |
missense |
probably damaging |
1.00 |
R9028:Nox3
|
UTSW |
17 |
3,716,185 (GRCm39) |
missense |
possibly damaging |
0.62 |
R9128:Nox3
|
UTSW |
17 |
3,720,136 (GRCm39) |
missense |
probably damaging |
1.00 |
R9581:Nox3
|
UTSW |
17 |
3,700,328 (GRCm39) |
missense |
possibly damaging |
0.95 |
R9780:Nox3
|
UTSW |
17 |
3,736,260 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
Predicted Primers |
PCR Primer
(F):5'- GATGAGATCACTGCTATGGGCCAC -3'
(R):5'- AATTCCTTGAGAGCTGCTCCCAAC -3'
Sequencing Primer
(F):5'- GTTTCACAGGCTGATTCACAGAC -3'
(R):5'- TGCTCCCAACAGGTGCTC -3'
|
Posted On |
2014-01-29 |