Incidental Mutation 'R1265:Cntnap5a'
ID 151136
Institutional Source Beutler Lab
Gene Symbol Cntnap5a
Ensembl Gene ENSMUSG00000070695
Gene Name contactin associated protein-like 5A
Synonyms Caspr5-1
MMRRC Submission 039332-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1265 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 115612486-116515053 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 116356248 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 760 (T760A)
Ref Sequence ENSEMBL: ENSMUSP00000035732 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043725]
AlphaFold Q0V8T9
Predicted Effect possibly damaging
Transcript: ENSMUST00000043725
AA Change: T760A

PolyPhen 2 Score 0.487 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000035732
Gene: ENSMUSG00000070695
AA Change: T760A

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
FA58C 33 174 1.63e-13 SMART
LamG 201 338 1.4e-26 SMART
LamG 388 522 1.5e-26 SMART
EGF 550 584 2.16e-1 SMART
Blast:FBG 587 772 2e-81 BLAST
LamG 812 939 1.54e-28 SMART
EGF 960 996 2.28e0 SMART
LamG 1037 1173 4.73e-15 SMART
transmembrane domain 1241 1263 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 95.9%
  • 20x: 91.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi1 T C 2: 22,836,734 (GRCm39) D316G possibly damaging Het
Aebp1 T C 11: 5,821,740 (GRCm39) V713A probably damaging Het
Alg2 T C 4: 47,474,289 (GRCm39) probably benign Het
Ank1 T A 8: 23,607,053 (GRCm39) V1273E possibly damaging Het
Fam120a G T 13: 49,039,219 (GRCm39) A979E possibly damaging Het
Igf2r A T 17: 12,913,011 (GRCm39) V1779E probably damaging Het
Lrp1b C T 2: 41,366,666 (GRCm39) V537M probably damaging Het
Ltbp1 A G 17: 75,532,280 (GRCm39) Q118R possibly damaging Het
Ly6h T A 15: 75,438,032 (GRCm39) M27L probably benign Het
Nphs2 A G 1: 156,146,317 (GRCm39) T173A probably damaging Het
Nsd3 T C 8: 26,172,578 (GRCm39) V779A probably benign Het
Or3a1d T C 11: 74,237,766 (GRCm39) I95V probably benign Het
Pdzd7 T C 19: 45,029,124 (GRCm39) D82G possibly damaging Het
Pkp2 A G 16: 16,043,168 (GRCm39) N76S probably benign Het
Ppip5k2 A G 1: 97,647,625 (GRCm39) S976P probably benign Het
Slc38a3 A G 9: 107,529,185 (GRCm39) F489S probably damaging Het
Sox11 T C 12: 27,391,735 (GRCm39) T225A probably benign Het
Tbx10 T C 19: 4,046,625 (GRCm39) F35S probably damaging Het
Tcf4 T C 18: 69,776,003 (GRCm39) M40T possibly damaging Het
Tenm2 C T 11: 35,954,004 (GRCm39) G1236R possibly damaging Het
Thsd7a T C 6: 12,317,418 (GRCm39) N1630S probably damaging Het
Urb2 A G 8: 124,751,892 (GRCm39) D75G probably damaging Het
Other mutations in Cntnap5a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00763:Cntnap5a APN 1 116,045,407 (GRCm39) missense possibly damaging 0.48
IGL00929:Cntnap5a APN 1 115,988,004 (GRCm39) splice site probably null
IGL00959:Cntnap5a APN 1 116,112,057 (GRCm39) missense probably benign 0.00
IGL01721:Cntnap5a APN 1 116,085,367 (GRCm39) missense probably benign
IGL02009:Cntnap5a APN 1 116,085,224 (GRCm39) missense probably benign 0.15
IGL02111:Cntnap5a APN 1 116,017,082 (GRCm39) missense probably benign 0.00
IGL02198:Cntnap5a APN 1 116,508,262 (GRCm39) missense probably benign
IGL02751:Cntnap5a APN 1 116,112,187 (GRCm39) critical splice donor site probably null
IGL02752:Cntnap5a APN 1 116,508,261 (GRCm39) missense probably benign 0.00
IGL02989:Cntnap5a APN 1 116,339,813 (GRCm39) splice site probably benign
IGL03195:Cntnap5a APN 1 116,085,178 (GRCm39) missense probably benign 0.00
PIT4142001:Cntnap5a UTSW 1 115,612,686 (GRCm39) start gained probably benign
R0294:Cntnap5a UTSW 1 115,843,046 (GRCm39) missense probably benign
R0377:Cntnap5a UTSW 1 116,220,259 (GRCm39) missense probably benign 0.04
R0597:Cntnap5a UTSW 1 116,112,191 (GRCm39) splice site probably benign
R0616:Cntnap5a UTSW 1 116,508,279 (GRCm39) missense possibly damaging 0.80
R0725:Cntnap5a UTSW 1 116,220,206 (GRCm39) missense probably benign 0.25
R0842:Cntnap5a UTSW 1 116,369,953 (GRCm39) missense probably damaging 0.96
R1103:Cntnap5a UTSW 1 116,508,399 (GRCm39) missense possibly damaging 0.81
R1467:Cntnap5a UTSW 1 115,612,898 (GRCm39) nonsense probably null
R1467:Cntnap5a UTSW 1 115,612,898 (GRCm39) nonsense probably null
R1470:Cntnap5a UTSW 1 116,187,249 (GRCm39) missense probably damaging 1.00
R1470:Cntnap5a UTSW 1 116,187,249 (GRCm39) missense probably damaging 1.00
R1474:Cntnap5a UTSW 1 116,370,103 (GRCm39) nonsense probably null
R1476:Cntnap5a UTSW 1 115,828,750 (GRCm39) missense probably damaging 1.00
R1481:Cntnap5a UTSW 1 116,045,393 (GRCm39) missense probably damaging 1.00
R1512:Cntnap5a UTSW 1 115,828,680 (GRCm39) missense probably benign
R1526:Cntnap5a UTSW 1 116,356,207 (GRCm39) missense probably benign
R1589:Cntnap5a UTSW 1 115,987,930 (GRCm39) missense possibly damaging 0.77
R1603:Cntnap5a UTSW 1 116,339,831 (GRCm39) missense possibly damaging 0.80
R1728:Cntnap5a UTSW 1 116,382,873 (GRCm39) missense probably benign 0.01
R1728:Cntnap5a UTSW 1 116,382,734 (GRCm39) missense probably benign 0.00
R1728:Cntnap5a UTSW 1 116,382,831 (GRCm39) missense probably benign 0.00
R1729:Cntnap5a UTSW 1 116,382,873 (GRCm39) missense probably benign 0.01
R1729:Cntnap5a UTSW 1 116,382,734 (GRCm39) missense probably benign 0.00
R1729:Cntnap5a UTSW 1 116,382,831 (GRCm39) missense probably benign 0.00
R1730:Cntnap5a UTSW 1 116,382,873 (GRCm39) missense probably benign 0.01
R1730:Cntnap5a UTSW 1 116,382,734 (GRCm39) missense probably benign 0.00
R1730:Cntnap5a UTSW 1 116,382,831 (GRCm39) missense probably benign 0.00
R1739:Cntnap5a UTSW 1 116,382,873 (GRCm39) missense probably benign 0.01
R1739:Cntnap5a UTSW 1 116,382,734 (GRCm39) missense probably benign 0.00
R1739:Cntnap5a UTSW 1 116,382,831 (GRCm39) missense probably benign 0.00
R1762:Cntnap5a UTSW 1 116,382,831 (GRCm39) missense probably benign 0.00
R1762:Cntnap5a UTSW 1 116,382,873 (GRCm39) missense probably benign 0.01
R1762:Cntnap5a UTSW 1 116,382,734 (GRCm39) missense probably benign 0.00
R1783:Cntnap5a UTSW 1 116,382,873 (GRCm39) missense probably benign 0.01
R1783:Cntnap5a UTSW 1 116,382,734 (GRCm39) missense probably benign 0.00
R1783:Cntnap5a UTSW 1 116,382,831 (GRCm39) missense probably benign 0.00
R1785:Cntnap5a UTSW 1 116,382,734 (GRCm39) missense probably benign 0.00
R1785:Cntnap5a UTSW 1 116,382,831 (GRCm39) missense probably benign 0.00
R1785:Cntnap5a UTSW 1 116,382,873 (GRCm39) missense probably benign 0.01
R1816:Cntnap5a UTSW 1 116,356,618 (GRCm39) missense probably benign 0.19
R1872:Cntnap5a UTSW 1 116,016,940 (GRCm39) missense probably benign 0.02
R2095:Cntnap5a UTSW 1 116,369,990 (GRCm39) missense probably damaging 1.00
R2113:Cntnap5a UTSW 1 116,116,095 (GRCm39) missense probably damaging 0.98
R2144:Cntnap5a UTSW 1 116,029,440 (GRCm39) missense probably benign 0.14
R2171:Cntnap5a UTSW 1 116,116,132 (GRCm39) missense possibly damaging 0.95
R2219:Cntnap5a UTSW 1 116,508,369 (GRCm39) missense possibly damaging 0.83
R2220:Cntnap5a UTSW 1 116,508,369 (GRCm39) missense possibly damaging 0.83
R2571:Cntnap5a UTSW 1 116,112,092 (GRCm39) missense probably damaging 1.00
R3019:Cntnap5a UTSW 1 116,029,299 (GRCm39) missense probably benign
R3827:Cntnap5a UTSW 1 116,045,409 (GRCm39) missense probably benign 0.14
R3870:Cntnap5a UTSW 1 115,987,979 (GRCm39) missense probably damaging 1.00
R3871:Cntnap5a UTSW 1 115,987,979 (GRCm39) missense probably damaging 1.00
R4041:Cntnap5a UTSW 1 116,112,129 (GRCm39) missense probably benign 0.00
R4080:Cntnap5a UTSW 1 116,029,304 (GRCm39) missense probably benign 0.01
R4260:Cntnap5a UTSW 1 116,374,325 (GRCm39) missense probably benign 0.31
R4685:Cntnap5a UTSW 1 116,374,410 (GRCm39) missense possibly damaging 0.69
R4781:Cntnap5a UTSW 1 116,339,931 (GRCm39) missense possibly damaging 0.88
R4785:Cntnap5a UTSW 1 116,029,295 (GRCm39) missense probably benign 0.00
R5057:Cntnap5a UTSW 1 115,612,943 (GRCm39) missense probably benign 0.10
R5059:Cntnap5a UTSW 1 116,356,224 (GRCm39) missense probably benign 0.44
R5101:Cntnap5a UTSW 1 116,370,026 (GRCm39) missense probably benign 0.00
R5302:Cntnap5a UTSW 1 116,085,300 (GRCm39) missense probably benign 0.15
R5451:Cntnap5a UTSW 1 115,612,873 (GRCm39) missense probably benign
R5473:Cntnap5a UTSW 1 116,016,986 (GRCm39) missense probably benign 0.12
R5886:Cntnap5a UTSW 1 116,499,402 (GRCm39) critical splice donor site probably null
R6311:Cntnap5a UTSW 1 116,339,836 (GRCm39) nonsense probably null
R6464:Cntnap5a UTSW 1 116,112,138 (GRCm39) missense probably benign
R6497:Cntnap5a UTSW 1 116,505,627 (GRCm39) missense probably damaging 1.00
R6781:Cntnap5a UTSW 1 116,220,127 (GRCm39) missense probably benign 0.05
R7137:Cntnap5a UTSW 1 116,017,106 (GRCm39) missense probably damaging 1.00
R7290:Cntnap5a UTSW 1 116,149,619 (GRCm39) missense probably damaging 1.00
R7342:Cntnap5a UTSW 1 115,987,852 (GRCm39) missense probably benign 0.00
R7367:Cntnap5a UTSW 1 116,370,025 (GRCm39) missense probably benign 0.00
R7373:Cntnap5a UTSW 1 116,508,367 (GRCm39) missense probably benign 0.20
R7426:Cntnap5a UTSW 1 116,370,110 (GRCm39) missense probably benign 0.03
R7444:Cntnap5a UTSW 1 116,220,079 (GRCm39) missense probably benign
R7582:Cntnap5a UTSW 1 116,374,362 (GRCm39) missense probably damaging 1.00
R7745:Cntnap5a UTSW 1 116,370,013 (GRCm39) missense probably benign
R7948:Cntnap5a UTSW 1 116,508,258 (GRCm39) missense probably benign 0.01
R7995:Cntnap5a UTSW 1 116,499,277 (GRCm39) missense probably damaging 0.99
R8041:Cntnap5a UTSW 1 116,187,209 (GRCm39) missense probably damaging 0.99
R8262:Cntnap5a UTSW 1 116,116,140 (GRCm39) missense possibly damaging 0.66
R8273:Cntnap5a UTSW 1 116,499,271 (GRCm39) missense probably damaging 1.00
R8320:Cntnap5a UTSW 1 116,374,466 (GRCm39) missense possibly damaging 0.62
R9242:Cntnap5a UTSW 1 116,220,109 (GRCm39) missense probably benign 0.06
R9470:Cntnap5a UTSW 1 116,374,344 (GRCm39) missense probably damaging 1.00
R9601:Cntnap5a UTSW 1 116,508,217 (GRCm39) missense probably damaging 0.96
R9616:Cntnap5a UTSW 1 116,029,323 (GRCm39) missense probably benign
R9623:Cntnap5a UTSW 1 116,369,985 (GRCm39) nonsense probably null
Z1088:Cntnap5a UTSW 1 115,987,981 (GRCm39) missense probably benign 0.08
Z1176:Cntnap5a UTSW 1 116,356,246 (GRCm39) missense probably damaging 1.00
Z1177:Cntnap5a UTSW 1 116,339,898 (GRCm39) missense probably benign 0.03
Z1188:Cntnap5a UTSW 1 116,445,935 (GRCm39) missense possibly damaging 0.70
Predicted Primers PCR Primer
(F):5'- GCTCTTTCCAACCCTAGCCAAACTG -3'
(R):5'- GAACCCTGTACTGTGAACCACTGAC -3'

Sequencing Primer
(F):5'- AACTGCATCCAATCCATGTCTC -3'
(R):5'- TTCCAGAAGTGCCCTGTAAAG -3'
Posted On 2014-01-29