Incidental Mutation 'R1265:Ly6h'
ID 151151
Institutional Source Beutler Lab
Gene Symbol Ly6h
Ensembl Gene ENSMUSG00000022577
Gene Name lymphocyte antigen 6 family member H
Synonyms
MMRRC Submission 039332-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R1265 (G1)
Quality Score 179
Status Not validated
Chromosome 15
Chromosomal Location 75436594-75439114 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 75438032 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 27 (M27L)
Ref Sequence ENSEMBL: ENSMUSP00000122878 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023241] [ENSMUST00000065417] [ENSMUST00000126129] [ENSMUST00000127095] [ENSMUST00000156032] [ENSMUST00000163116]
AlphaFold Q9WUC3
Predicted Effect probably benign
Transcript: ENSMUST00000023241
AA Change: M6L

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000023241
Gene: ENSMUSG00000022577
AA Change: M6L

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
LU 26 123 2.68e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000065417
AA Change: M6L

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000070646
Gene: ENSMUSG00000022577
AA Change: M6L

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
LU 26 123 2.68e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000126129
AA Change: M6L

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000121951
Gene: ENSMUSG00000022577
AA Change: M6L

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
LU 26 123 2.68e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000127095
AA Change: M27L

PolyPhen 2 Score 0.049 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000122061
Gene: ENSMUSG00000022577
AA Change: M27L

DomainStartEndE-ValueType
signal peptide 1 46 N/A INTRINSIC
LU 47 144 2.68e-6 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150125
Predicted Effect probably benign
Transcript: ENSMUST00000156032
AA Change: M27L

PolyPhen 2 Score 0.049 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000122878
Gene: ENSMUSG00000022577
AA Change: M27L

DomainStartEndE-ValueType
signal peptide 1 46 N/A INTRINSIC
LU 47 144 2.68e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000163116
AA Change: M6L

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000130781
Gene: ENSMUSG00000022577
AA Change: M6L

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
LU 26 123 2.68e-6 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228961
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 95.9%
  • 20x: 91.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi1 T C 2: 22,836,734 (GRCm39) D316G possibly damaging Het
Aebp1 T C 11: 5,821,740 (GRCm39) V713A probably damaging Het
Alg2 T C 4: 47,474,289 (GRCm39) probably benign Het
Ank1 T A 8: 23,607,053 (GRCm39) V1273E possibly damaging Het
Cntnap5a A G 1: 116,356,248 (GRCm39) T760A possibly damaging Het
Fam120a G T 13: 49,039,219 (GRCm39) A979E possibly damaging Het
Igf2r A T 17: 12,913,011 (GRCm39) V1779E probably damaging Het
Lrp1b C T 2: 41,366,666 (GRCm39) V537M probably damaging Het
Ltbp1 A G 17: 75,532,280 (GRCm39) Q118R possibly damaging Het
Nphs2 A G 1: 156,146,317 (GRCm39) T173A probably damaging Het
Nsd3 T C 8: 26,172,578 (GRCm39) V779A probably benign Het
Or3a1d T C 11: 74,237,766 (GRCm39) I95V probably benign Het
Pdzd7 T C 19: 45,029,124 (GRCm39) D82G possibly damaging Het
Pkp2 A G 16: 16,043,168 (GRCm39) N76S probably benign Het
Ppip5k2 A G 1: 97,647,625 (GRCm39) S976P probably benign Het
Slc38a3 A G 9: 107,529,185 (GRCm39) F489S probably damaging Het
Sox11 T C 12: 27,391,735 (GRCm39) T225A probably benign Het
Tbx10 T C 19: 4,046,625 (GRCm39) F35S probably damaging Het
Tcf4 T C 18: 69,776,003 (GRCm39) M40T possibly damaging Het
Tenm2 C T 11: 35,954,004 (GRCm39) G1236R possibly damaging Het
Thsd7a T C 6: 12,317,418 (GRCm39) N1630S probably damaging Het
Urb2 A G 8: 124,751,892 (GRCm39) D75G probably damaging Het
Other mutations in Ly6h
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01327:Ly6h APN 15 75,436,948 (GRCm39) utr 3 prime probably benign
R1148:Ly6h UTSW 15 75,437,021 (GRCm39) missense unknown
R1148:Ly6h UTSW 15 75,437,021 (GRCm39) missense unknown
R1468:Ly6h UTSW 15 75,437,986 (GRCm39) missense probably benign 0.09
R1468:Ly6h UTSW 15 75,437,986 (GRCm39) missense probably benign 0.09
R2235:Ly6h UTSW 15 75,437,038 (GRCm39) missense probably benign
R6918:Ly6h UTSW 15 75,437,507 (GRCm39) missense probably damaging 0.99
R8058:Ly6h UTSW 15 75,437,061 (GRCm39) missense probably benign 0.01
R8807:Ly6h UTSW 15 75,438,056 (GRCm39) missense probably benign 0.05
R9131:Ly6h UTSW 15 75,437,522 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GGTTCCAAGACAGGAAAGGTCCAC -3'
(R):5'- GGGATGGTTACATCTTCAGGCCAG -3'

Sequencing Primer
(F):5'- TCGCTGAACCTCTGAGAATG -3'
(R):5'- GTTACATCTTCAGGCCAGAAAAG -3'
Posted On 2014-01-29