|Institutional Source||Beutler Lab|
|Gene Name||netrin 1|
|Is this an essential gene?||Possibly essential (E-score: 0.723)|
|Stock #||R1268 (G1)|
|Chromosomal Location||68209364-68400823 bp(-) (GRCm38)|
|Type of Mutation||small deletion (2 aa in frame mutation)|
|DNA Base Change (assembly)||TCCTCGGC to TC at 68213133 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000104314 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000021284] [ENSMUST00000108674]|
|Coding Region Coverage||
|Validation Efficiency||100% (41/41)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for targeted mutations exhibit impaired axonal migration, abnormal semicircular canals, lack of corpus callosum, aberrant commissures, hypoplasia of the optic nerve, motor and balance defects, failure to suckle, and neonatal death. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ntn1||
(F):5'- GTAGACCACTGTGCCATTCTGTTCC -3'
(R):5'- TTCACCGTGAACATCATCTCCGTG -3'
(F):5'- AGGGAAGCGCATCTCTGTTC -3'
(R):5'- TCATCTCCGTGTACAAGCAGG -3'