Incidental Mutation 'R1270:Mrgpra9'
ID |
151275 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Mrgpra9
|
Ensembl Gene |
ENSMUSG00000074111 |
Gene Name |
MAS-related GPR, member A9 |
Synonyms |
MrgA9, EG668725 |
MMRRC Submission |
039336-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.049)
|
Stock # |
R1270 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
46884667-46902627 bp(-) (GRCm39) |
Type of Mutation |
critical splice donor site (2 bp from exon) |
DNA Base Change (assembly) |
A to T
at 46902531 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000136396
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000098436]
[ENSMUST00000179005]
|
AlphaFold |
A0A140T8U8 |
Predicted Effect |
probably null
Transcript: ENSMUST00000098436
|
SMART Domains |
Protein: ENSMUSP00000096035 Gene: ENSMUSG00000074111
Domain | Start | End | E-Value | Type |
low complexity region
|
37 |
48 |
N/A |
INTRINSIC |
Pfam:7tm_1
|
56 |
225 |
1.5e-11 |
PFAM |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000179005
|
SMART Domains |
Protein: ENSMUSP00000136396 Gene: ENSMUSG00000074111
Domain | Start | End | E-Value | Type |
Pfam:7tm_1
|
12 |
178 |
3.4e-9 |
PFAM |
|
Meta Mutation Damage Score |
0.9755 |
Coding Region Coverage |
- 1x: 98.9%
- 3x: 98.1%
- 10x: 95.5%
- 20x: 89.7%
|
Validation Efficiency |
97% (36/37) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 32 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abcc3 |
C |
T |
11: 94,248,210 (GRCm39) |
R1129Q |
probably damaging |
Het |
Adam7 |
T |
A |
14: 68,765,118 (GRCm39) |
K93M |
probably damaging |
Het |
Aldh1a2 |
T |
G |
9: 71,188,988 (GRCm39) |
L301V |
probably benign |
Het |
Alg9 |
A |
G |
9: 50,698,872 (GRCm39) |
|
probably benign |
Het |
Aspg |
C |
T |
12: 112,082,881 (GRCm39) |
T187I |
probably damaging |
Het |
Bltp1 |
T |
A |
3: 37,006,333 (GRCm39) |
H1662Q |
probably damaging |
Het |
C4a |
A |
G |
17: 35,033,505 (GRCm39) |
|
noncoding transcript |
Het |
Cdh2 |
T |
G |
18: 16,760,614 (GRCm39) |
|
probably benign |
Het |
Ceacam1 |
T |
C |
7: 25,165,739 (GRCm39) |
|
probably null |
Het |
Cep250 |
G |
A |
2: 155,832,601 (GRCm39) |
V1509I |
probably benign |
Het |
D130043K22Rik |
T |
C |
13: 25,041,321 (GRCm39) |
S248P |
probably benign |
Het |
Dgkd |
A |
T |
1: 87,861,847 (GRCm39) |
M801L |
probably damaging |
Het |
Edc4 |
A |
G |
8: 106,617,896 (GRCm39) |
E1152G |
possibly damaging |
Het |
Enkd1 |
A |
G |
8: 106,430,533 (GRCm39) |
I334T |
probably damaging |
Het |
Gli3 |
C |
T |
13: 15,898,329 (GRCm39) |
A803V |
probably benign |
Het |
Glrx3 |
A |
G |
7: 137,055,143 (GRCm39) |
N95S |
probably benign |
Het |
Ints2 |
C |
T |
11: 86,123,911 (GRCm39) |
G626R |
probably damaging |
Het |
Kank2 |
A |
T |
9: 21,684,056 (GRCm39) |
N724K |
probably damaging |
Het |
Kctd20 |
A |
G |
17: 29,185,905 (GRCm39) |
D416G |
possibly damaging |
Het |
Lmtk3 |
A |
G |
7: 45,443,252 (GRCm39) |
E645G |
probably damaging |
Het |
Muc1 |
T |
A |
3: 89,139,414 (GRCm39) |
Y605N |
probably damaging |
Het |
Or4a47 |
C |
T |
2: 89,665,666 (GRCm39) |
V208M |
possibly damaging |
Het |
Or8g17 |
A |
C |
9: 38,930,543 (GRCm39) |
I98R |
possibly damaging |
Het |
Prx |
T |
A |
7: 27,218,355 (GRCm39) |
I952N |
probably damaging |
Het |
Shf |
G |
A |
2: 122,199,163 (GRCm39) |
P51S |
probably damaging |
Het |
Skint5 |
A |
T |
4: 113,799,856 (GRCm39) |
Y90* |
probably null |
Het |
Swt1 |
A |
T |
1: 151,260,142 (GRCm39) |
N752K |
probably benign |
Het |
Taar1 |
T |
C |
10: 23,796,431 (GRCm39) |
V43A |
probably damaging |
Het |
Tenm2 |
T |
C |
11: 35,932,486 (GRCm39) |
N1702D |
probably damaging |
Het |
Tff2 |
C |
T |
17: 31,363,143 (GRCm39) |
|
probably null |
Het |
Trim2 |
G |
A |
3: 84,074,984 (GRCm39) |
A686V |
probably damaging |
Het |
Ube2q2l |
A |
T |
6: 136,378,785 (GRCm39) |
I15N |
probably damaging |
Het |
|
Other mutations in Mrgpra9 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00095:Mrgpra9
|
APN |
7 |
46,884,839 (GRCm39) |
missense |
possibly damaging |
0.85 |
IGL00575:Mrgpra9
|
APN |
7 |
46,885,053 (GRCm39) |
missense |
possibly damaging |
0.76 |
IGL01649:Mrgpra9
|
APN |
7 |
46,884,900 (GRCm39) |
missense |
probably benign |
0.22 |
IGL03207:Mrgpra9
|
APN |
7 |
46,885,385 (GRCm39) |
missense |
possibly damaging |
0.68 |
R0388:Mrgpra9
|
UTSW |
7 |
46,902,542 (GRCm39) |
start codon destroyed |
probably null |
0.08 |
R0972:Mrgpra9
|
UTSW |
7 |
46,885,203 (GRCm39) |
missense |
probably damaging |
0.99 |
R1381:Mrgpra9
|
UTSW |
7 |
46,885,050 (GRCm39) |
missense |
possibly damaging |
0.75 |
R1403:Mrgpra9
|
UTSW |
7 |
46,885,386 (GRCm39) |
missense |
probably benign |
0.24 |
R1403:Mrgpra9
|
UTSW |
7 |
46,885,386 (GRCm39) |
missense |
probably benign |
0.24 |
R1448:Mrgpra9
|
UTSW |
7 |
46,885,561 (GRCm39) |
missense |
probably benign |
0.02 |
R2045:Mrgpra9
|
UTSW |
7 |
46,885,583 (GRCm39) |
missense |
probably benign |
|
R2144:Mrgpra9
|
UTSW |
7 |
46,885,211 (GRCm39) |
missense |
probably benign |
0.31 |
R2187:Mrgpra9
|
UTSW |
7 |
46,884,797 (GRCm39) |
missense |
probably damaging |
1.00 |
R2507:Mrgpra9
|
UTSW |
7 |
46,885,242 (GRCm39) |
missense |
possibly damaging |
0.63 |
R2913:Mrgpra9
|
UTSW |
7 |
46,884,828 (GRCm39) |
missense |
probably benign |
|
R3810:Mrgpra9
|
UTSW |
7 |
46,885,527 (GRCm39) |
missense |
probably damaging |
0.98 |
R4177:Mrgpra9
|
UTSW |
7 |
46,885,302 (GRCm39) |
missense |
probably damaging |
1.00 |
R4521:Mrgpra9
|
UTSW |
7 |
46,884,938 (GRCm39) |
missense |
probably damaging |
1.00 |
R4781:Mrgpra9
|
UTSW |
7 |
46,884,795 (GRCm39) |
missense |
possibly damaging |
0.88 |
R4926:Mrgpra9
|
UTSW |
7 |
46,884,759 (GRCm39) |
missense |
possibly damaging |
0.62 |
R6469:Mrgpra9
|
UTSW |
7 |
46,884,854 (GRCm39) |
missense |
probably benign |
0.02 |
R6505:Mrgpra9
|
UTSW |
7 |
46,884,884 (GRCm39) |
missense |
probably benign |
0.00 |
R6724:Mrgpra9
|
UTSW |
7 |
46,884,786 (GRCm39) |
missense |
probably damaging |
1.00 |
R7398:Mrgpra9
|
UTSW |
7 |
46,885,385 (GRCm39) |
missense |
possibly damaging |
0.68 |
R8737:Mrgpra9
|
UTSW |
7 |
46,885,624 (GRCm39) |
missense |
probably benign |
0.00 |
R8824:Mrgpra9
|
UTSW |
7 |
46,885,041 (GRCm39) |
missense |
probably benign |
0.06 |
R8881:Mrgpra9
|
UTSW |
7 |
46,885,242 (GRCm39) |
missense |
possibly damaging |
0.63 |
R9320:Mrgpra9
|
UTSW |
7 |
46,885,392 (GRCm39) |
missense |
probably benign |
0.00 |
|
Predicted Primers |
PCR Primer
(F):5'- CAGCTTCTAACCACTCACTGTCCAG -3'
(R):5'- AGGTGGCAGGAAACTCCAATCAAC -3'
Sequencing Primer
(F):5'- GCCTGTCTGCACCAAACTC -3'
(R):5'- CCAGAGATTGAGAACTGTCTCAGG -3'
|
Posted On |
2014-01-29 |