Incidental Mutation 'R1255:Zfp729a'
ID 151428
Institutional Source Beutler Lab
Gene Symbol Zfp729a
Ensembl Gene ENSMUSG00000021510
Gene Name zinc finger protein 729a
Synonyms A530054K11Rik
MMRRC Submission 039322-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R1255 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 67760882-67785910 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 67769965 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 88 (E88G)
Ref Sequence ENSEMBL: ENSMUSP00000012314 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000012314] [ENSMUST00000224814] [ENSMUST00000225627]
AlphaFold Q4QQP3
Predicted Effect probably benign
Transcript: ENSMUST00000012314
AA Change: E88G

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000012314
Gene: ENSMUSG00000021510
AA Change: E88G

DomainStartEndE-ValueType
KRAB 15 75 6.23e-34 SMART
ZnF_C2H2 91 111 1.91e1 SMART
ZnF_C2H2 147 169 8.34e-3 SMART
PHD 148 209 9.1e0 SMART
ZnF_C2H2 175 197 3.21e-4 SMART
ZnF_C2H2 203 225 6.78e-3 SMART
ZnF_C2H2 231 253 4.47e-3 SMART
PHD 232 293 1.11e1 SMART
RING 233 292 9.27e0 SMART
ZnF_C2H2 259 281 6.67e-2 SMART
ZnF_C2H2 287 309 1.12e-3 SMART
ZnF_C2H2 315 337 3.83e-2 SMART
PHD 316 377 1.35e1 SMART
ZnF_C2H2 343 365 2.57e-3 SMART
ZnF_C2H2 371 393 1.98e-4 SMART
Pfam:zf-C2HC_2 402 422 7.7e-4 PFAM
ZnF_C2H2 427 449 1.67e-2 SMART
ZnF_C2H2 455 477 1.38e-3 SMART
PHD 456 517 5.33e0 SMART
RING 457 516 9.02e0 SMART
ZnF_C2H2 483 505 3.89e-3 SMART
ZnF_C2H2 511 533 7.49e-5 SMART
ZnF_C2H2 539 561 5.5e-3 SMART
PHD 540 601 1.46e1 SMART
ZnF_C2H2 567 589 3.58e-2 SMART
ZnF_C2H2 595 617 8.34e-3 SMART
ZnF_C2H2 651 673 4.11e-2 SMART
PHD 652 713 4.64e0 SMART
RING 653 712 6.37e0 SMART
ZnF_C2H2 679 701 2.4e-3 SMART
ZnF_C2H2 707 729 1.03e-2 SMART
ZnF_C2H2 735 757 1.47e-3 SMART
PHD 736 797 5.44e0 SMART
RING 737 796 5.88e0 SMART
ZnF_C2H2 763 785 6.67e-2 SMART
ZnF_C2H2 791 813 2.36e-2 SMART
ZnF_C2H2 819 841 6.32e-3 SMART
ZnF_C2H2 847 869 1.26e-2 SMART
ZnF_C2H2 875 897 6.78e-3 SMART
PHD 876 937 4.55e0 SMART
ZnF_C2H2 903 925 9.58e-3 SMART
ZnF_C2H2 931 953 9.08e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224548
Predicted Effect probably benign
Transcript: ENSMUST00000224814
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225511
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225608
Predicted Effect probably benign
Transcript: ENSMUST00000225627
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 96.1%
  • 20x: 91.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 A T 7: 119,807,016 (GRCm39) S21C probably damaging Het
Abcb10 C T 8: 124,688,791 (GRCm39) G495D probably damaging Het
Acsf3 T C 8: 123,512,705 (GRCm39) probably null Het
Aff3 A T 1: 38,243,965 (GRCm39) probably null Het
Antxr2 A T 5: 98,123,231 (GRCm39) I272N probably benign Het
Asphd2 A C 5: 112,539,677 (GRCm39) V52G probably damaging Het
Atxn3 T A 12: 101,900,593 (GRCm39) Q230L probably damaging Het
Bltp3b T C 10: 89,581,132 (GRCm39) I9T probably damaging Het
Ccdc39 T C 3: 33,880,629 (GRCm39) K446R probably damaging Het
Ciz1 T A 2: 32,255,888 (GRCm39) probably null Het
Dennd5b A T 6: 148,943,148 (GRCm39) M576K possibly damaging Het
Ebf3 C T 7: 136,826,941 (GRCm39) V315I probably benign Het
Epha5 G T 5: 84,298,254 (GRCm39) A383E probably damaging Het
Epha5 C T 5: 84,298,255 (GRCm39) A383T probably damaging Het
Gimap1 T A 6: 48,719,940 (GRCm39) V184E probably benign Het
Gtf2f1 A G 17: 57,317,982 (GRCm39) V18A probably damaging Het
Kcnn3 A T 3: 89,559,416 (GRCm39) D562V possibly damaging Het
Kif20b A G 19: 34,927,506 (GRCm39) T883A probably benign Het
Kmt2c A T 5: 25,556,151 (GRCm39) L1198Q probably damaging Het
Nipal2 T C 15: 34,584,828 (GRCm39) I247V probably benign Het
Or5ak22 T A 2: 85,230,647 (GRCm39) I77F probably damaging Het
Rad51ap2 G T 12: 11,508,095 (GRCm39) K672N possibly damaging Het
Rbm28 C T 6: 29,158,246 (GRCm39) G155D probably damaging Het
Sema6a A T 18: 47,382,366 (GRCm39) M701K probably damaging Het
Slc47a1 A T 11: 61,260,974 (GRCm39) L142Q probably damaging Het
Snx25 A T 8: 46,569,275 (GRCm39) N207K probably benign Het
Son T A 16: 91,461,583 (GRCm39) V205E probably damaging Het
Spz1 C A 13: 92,712,138 (GRCm39) V113F probably benign Het
Tcn2 T C 11: 3,872,120 (GRCm39) T336A probably benign Het
Tln1 T C 4: 43,538,044 (GRCm39) D1852G probably damaging Het
Ugcg C T 4: 59,207,798 (GRCm39) P46S probably benign Het
Other mutations in Zfp729a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00572:Zfp729a APN 13 67,767,440 (GRCm39) missense probably benign 0.01
IGL01956:Zfp729a APN 13 67,769,805 (GRCm39) missense probably damaging 1.00
IGL02852:Zfp729a APN 13 67,768,070 (GRCm39) missense possibly damaging 0.69
IGL03130:Zfp729a APN 13 67,767,761 (GRCm39) splice site probably null
adalet UTSW 13 67,767,626 (GRCm39) missense probably benign 0.00
R0329:Zfp729a UTSW 13 67,768,473 (GRCm39) missense probably damaging 1.00
R0330:Zfp729a UTSW 13 67,768,473 (GRCm39) missense probably damaging 1.00
R0383:Zfp729a UTSW 13 67,769,792 (GRCm39) missense possibly damaging 0.83
R0545:Zfp729a UTSW 13 67,768,345 (GRCm39) missense probably benign 0.09
R1013:Zfp729a UTSW 13 67,767,626 (GRCm39) missense probably benign 0.00
R1079:Zfp729a UTSW 13 67,767,794 (GRCm39) missense possibly damaging 0.71
R1525:Zfp729a UTSW 13 67,767,440 (GRCm39) missense probably benign 0.01
R1768:Zfp729a UTSW 13 67,767,370 (GRCm39) missense probably benign 0.00
R1926:Zfp729a UTSW 13 67,767,676 (GRCm39) missense probably benign 0.29
R2043:Zfp729a UTSW 13 67,769,291 (GRCm39) missense probably damaging 1.00
R2118:Zfp729a UTSW 13 67,769,613 (GRCm39) splice site probably null
R3820:Zfp729a UTSW 13 67,769,438 (GRCm39) missense probably damaging 1.00
R3830:Zfp729a UTSW 13 67,767,997 (GRCm39) missense probably damaging 1.00
R3926:Zfp729a UTSW 13 67,768,310 (GRCm39) nonsense probably null
R4134:Zfp729a UTSW 13 67,767,925 (GRCm39) missense probably damaging 1.00
R4135:Zfp729a UTSW 13 67,767,925 (GRCm39) missense probably damaging 1.00
R4670:Zfp729a UTSW 13 67,769,534 (GRCm39) nonsense probably null
R4793:Zfp729a UTSW 13 67,768,546 (GRCm39) missense probably damaging 1.00
R5009:Zfp729a UTSW 13 67,768,365 (GRCm39) missense probably benign 0.01
R5125:Zfp729a UTSW 13 67,785,764 (GRCm39) critical splice donor site probably null
R5178:Zfp729a UTSW 13 67,785,764 (GRCm39) critical splice donor site probably null
R5438:Zfp729a UTSW 13 67,767,705 (GRCm39) missense possibly damaging 0.94
R6540:Zfp729a UTSW 13 67,767,767 (GRCm39) missense possibly damaging 0.81
R6731:Zfp729a UTSW 13 67,768,265 (GRCm39) missense probably benign 0.09
R6987:Zfp729a UTSW 13 67,768,058 (GRCm39) nonsense probably null
R7001:Zfp729a UTSW 13 67,768,468 (GRCm39) missense probably benign 0.31
R7626:Zfp729a UTSW 13 67,768,437 (GRCm39) nonsense probably null
R7706:Zfp729a UTSW 13 67,771,612 (GRCm39) missense possibly damaging 0.72
R7855:Zfp729a UTSW 13 67,768,067 (GRCm39) missense possibly damaging 0.94
R7864:Zfp729a UTSW 13 67,769,569 (GRCm39) missense probably benign 0.34
R7916:Zfp729a UTSW 13 67,768,294 (GRCm39) missense probably benign 0.20
R8061:Zfp729a UTSW 13 67,768,208 (GRCm39) missense probably benign
R8187:Zfp729a UTSW 13 67,769,918 (GRCm39) nonsense probably null
R8191:Zfp729a UTSW 13 67,769,838 (GRCm39) missense probably benign 0.01
R8275:Zfp729a UTSW 13 67,768,223 (GRCm39) missense probably benign 0.08
R8469:Zfp729a UTSW 13 67,769,481 (GRCm39) missense probably damaging 1.00
R8733:Zfp729a UTSW 13 67,769,104 (GRCm39) missense probably damaging 0.96
R8911:Zfp729a UTSW 13 67,768,061 (GRCm39) missense probably benign 0.25
R9211:Zfp729a UTSW 13 67,767,820 (GRCm39) missense probably benign 0.05
R9355:Zfp729a UTSW 13 67,767,515 (GRCm39) missense probably damaging 1.00
R9505:Zfp729a UTSW 13 67,767,673 (GRCm39) missense probably damaging 0.97
R9786:Zfp729a UTSW 13 67,768,628 (GRCm39) missense possibly damaging 0.83
X0010:Zfp729a UTSW 13 67,769,901 (GRCm39) missense probably damaging 0.98
Z1177:Zfp729a UTSW 13 67,768,350 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- GATGACAGAGAACGAAAAGCCTtttgac -3'
(R):5'- GCTCTTCTTTTAGTGGAAGGTGACATGA -3'

Sequencing Primer
(F):5'- aaagtaatgatggaaagtggaagg -3'
(R):5'- AGGTGACATGATTTTCACTATTTCTG -3'
Posted On 2014-01-29