Incidental Mutation 'R1256:Or5k14'
ID 151471
Institutional Source Beutler Lab
Gene Symbol Or5k14
Ensembl Gene ENSMUSG00000063137
Gene Name olfactory receptor family 5 subfamily K member 14
Synonyms Olfr176, GA_x54KRFPKG5P-55091371-55090442, MOR184-8, GA_x54KRFPKG5P-55043245-55042289, Olfr177, MOR184-7
MMRRC Submission 039323-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.132) question?
Stock # R1256 (G1)
Quality Score 225
Status Not validated
Chromosome 16
Chromosomal Location 58689766-58693511 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to C at 58693206 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 102 (Y102*)
Ref Sequence ENSEMBL: ENSMUSP00000150269 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072853] [ENSMUST00000217377]
AlphaFold E9Q7W1
Predicted Effect probably null
Transcript: ENSMUST00000072853
AA Change: Y102*
SMART Domains Protein: ENSMUSP00000072631
Gene: ENSMUSG00000063137
AA Change: Y102*

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.7e-53 PFAM
Pfam:7TM_GPCR_Srsx 35 254 8.3e-6 PFAM
Pfam:7tm_1 41 290 1.2e-17 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205920
AA Change: Y102*
Predicted Effect probably null
Transcript: ENSMUST00000217377
AA Change: Y102*
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb10 C T 8: 124,688,791 (GRCm39) G495D probably damaging Het
Apaf1 A G 10: 90,894,268 (GRCm39) Y456H probably benign Het
Arhgef11 A G 3: 87,634,442 (GRCm39) N791S possibly damaging Het
Brat1 A G 5: 140,695,962 (GRCm39) Q66R possibly damaging Het
Capn10 C T 1: 92,874,668 (GRCm39) T633M probably damaging Het
Ccdc186 G T 19: 56,786,053 (GRCm39) L661I probably benign Het
Cln3 A G 7: 126,182,208 (GRCm39) S4P probably damaging Het
Cnot10 G T 9: 114,439,749 (GRCm39) S520Y probably damaging Het
Csmd1 A T 8: 16,129,978 (GRCm39) F1715I probably damaging Het
Ezh2 A T 6: 47,518,789 (GRCm39) C545* probably null Het
Hivep1 C T 13: 42,335,307 (GRCm39) S2282F probably damaging Het
Jag2 T C 12: 112,878,039 (GRCm39) E564G possibly damaging Het
Kcnj16 A G 11: 110,916,262 (GRCm39) H308R probably damaging Het
Magi3 C T 3: 103,935,126 (GRCm39) V936I probably benign Het
Mcu G T 10: 59,290,790 (GRCm39) A279E probably damaging Het
Msln A G 17: 25,973,157 (GRCm39) C13R probably damaging Het
Nes A G 3: 87,883,883 (GRCm39) D714G probably benign Het
Nif3l1 T A 1: 58,494,808 (GRCm39) V259D probably damaging Het
Or4c127 A T 2: 89,832,911 (GRCm39) M54L possibly damaging Het
Or8g18 G C 9: 39,149,547 (GRCm39) P58A probably benign Het
Pcdhb9 A G 18: 37,536,169 (GRCm39) D721G possibly damaging Het
Pepd A C 7: 34,620,917 (GRCm39) T61P possibly damaging Het
Pkd1l2 C T 8: 117,746,282 (GRCm39) probably null Het
Poglut3 A C 9: 53,299,762 (GRCm39) R90S possibly damaging Het
Psip1 A G 4: 83,392,604 (GRCm39) S102P probably benign Het
Ralgapa1 T C 12: 55,809,446 (GRCm39) E443G possibly damaging Het
Rnf20 A G 4: 49,638,230 (GRCm39) D114G probably benign Het
Schip1 A T 3: 68,402,375 (GRCm39) I151F probably benign Het
Smarca2 A G 19: 26,659,373 (GRCm39) I888V probably benign Het
Smg1 T C 7: 117,802,310 (GRCm39) T263A probably damaging Het
Spn T C 7: 126,735,445 (GRCm39) K354R possibly damaging Het
Sspo G A 6: 48,434,573 (GRCm39) A1022T probably damaging Het
Strn A C 17: 78,972,046 (GRCm39) probably null Het
Tstd3 T C 4: 21,759,627 (GRCm39) I79M probably damaging Het
Txnl4a A G 18: 80,250,487 (GRCm39) I28V probably benign Het
Uty T C Y: 1,134,884 (GRCm39) D928G probably damaging Het
Vps26c A G 16: 94,313,225 (GRCm39) L22P probably damaging Het
Vsx2 T A 12: 84,623,085 (GRCm39) L163Q probably damaging Het
Other mutations in Or5k14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02084:Or5k14 APN 16 58,693,399 (GRCm39) missense probably damaging 1.00
IGL02223:Or5k14 APN 16 58,693,057 (GRCm39) missense probably damaging 1.00
R0131:Or5k14 UTSW 16 58,693,269 (GRCm39) missense probably benign 0.01
R0131:Or5k14 UTSW 16 58,693,269 (GRCm39) missense probably benign 0.01
R0132:Or5k14 UTSW 16 58,693,269 (GRCm39) missense probably benign 0.01
R0245:Or5k14 UTSW 16 58,693,229 (GRCm39) missense probably benign 0.01
R0717:Or5k14 UTSW 16 58,693,133 (GRCm39) missense probably damaging 1.00
R0975:Or5k14 UTSW 16 58,693,513 (GRCm39) splice site probably null
R1037:Or5k14 UTSW 16 58,693,333 (GRCm39) missense probably damaging 1.00
R1278:Or5k14 UTSW 16 58,693,340 (GRCm39) missense probably damaging 1.00
R1538:Or5k14 UTSW 16 58,693,261 (GRCm39) missense probably damaging 1.00
R1992:Or5k14 UTSW 16 58,692,874 (GRCm39) missense probably benign 0.43
R2173:Or5k14 UTSW 16 58,692,982 (GRCm39) missense probably damaging 0.99
R2392:Or5k14 UTSW 16 58,692,797 (GRCm39) missense probably damaging 1.00
R5651:Or5k14 UTSW 16 58,692,847 (GRCm39) missense probably damaging 0.99
R5652:Or5k14 UTSW 16 58,692,847 (GRCm39) missense probably damaging 0.99
R5653:Or5k14 UTSW 16 58,692,847 (GRCm39) missense probably damaging 0.99
R8031:Or5k14 UTSW 16 58,693,054 (GRCm39) missense probably benign 0.03
R8108:Or5k14 UTSW 16 58,692,599 (GRCm39) missense probably benign
R8531:Or5k14 UTSW 16 58,693,016 (GRCm39) missense probably damaging 1.00
R8833:Or5k14 UTSW 16 58,692,959 (GRCm39) missense probably damaging 0.99
R9150:Or5k14 UTSW 16 58,693,005 (GRCm39) nonsense probably null
R9318:Or5k14 UTSW 16 58,692,748 (GRCm39) missense probably damaging 1.00
R9389:Or5k14 UTSW 16 58,692,976 (GRCm39) missense probably damaging 1.00
V8831:Or5k14 UTSW 16 58,693,438 (GRCm39) missense probably benign 0.28
Predicted Primers PCR Primer
(F):5'- GTGAATCATGGAATGTAGGTTTCCTGCT -3'
(R):5'- AAAGACACTTCTGTTCCTGGTGTTCTC -3'

Sequencing Primer
(F):5'- TATGTAGGCTCCTGTGGTCATTTG -3'
(R):5'- AAATCTTGGGCTGGTGACC -3'
Posted On 2014-01-29