Mutagenetix > Incidental Mutation

Incidental Mutation 'R1259:Lypd9'

151554

Institutional Source

Beutler Lab

Gene Symbol

Lypd9

Ensembl Gene

ENSMUSG00000052642

Gene Name

LY6/PLAUR domain containing 9

Synonyms

4930504O13Rik

MMRRC Submission

039326-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.087) question?

Stock #

R1259 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

58336975-58343749 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 58338296 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 32 (I32T)

Ref Sequence

ENSEMBL: ENSMUSP00000063665 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064614]

AlphaFold

Q8C5Z9

Predicted Effect

probably benign
Transcript: ENSMUST00000064614
AA Change: I32T

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000063665
Gene: ENSMUSG00000052642
AA Change: I32T

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:UPAR_LY6	47	124	1.3e-6	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 94.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam26a	T	A	8: 44,021,684 (GRCm39)	D602V	probably benign	Het
Adam26a	T	C	8: 44,021,750 (GRCm39)	D580G	possibly damaging	Het
B4galt6	T	G	18: 20,839,559 (GRCm39)	E125A	possibly damaging	Het
Dnm1l	A	G	16: 16,141,870 (GRCm39)	I292T	possibly damaging	Het
Elp3	A	T	14: 65,785,388 (GRCm39)	I471K	probably damaging	Het
Fbxw13	A	T	9: 109,014,439 (GRCm39)	V83E	probably damaging	Het
Gm5422	T	C	10: 31,125,111 (GRCm39)		noncoding transcript	Het
Krtap6-5	C	T	16: 88,844,607 (GRCm39)	R42H	unknown	Het
Lpcat2b	C	T	5: 107,581,763 (GRCm39)	A364V	probably damaging	Het
Ltbp1	A	G	17: 75,532,280 (GRCm39)	Q118R	possibly damaging	Het
Med7	C	G	11: 46,331,460 (GRCm39)	I18M	probably damaging	Het
Muc6	T	A	7: 141,226,464 (GRCm39)		probably benign	Het
Or8b42	T	A	9: 38,342,169 (GRCm39)	L197Q	probably damaging	Het
Or8k16	T	A	2: 85,519,875 (GRCm39)	I34N	probably damaging	Het
Pbrm1	T	C	14: 30,796,771 (GRCm39)	F871L	probably damaging	Het
Pgbd5	T	A	8: 125,097,324 (GRCm39)	D493V	probably damaging	Het
Pik3cd	G	A	4: 149,735,105 (GRCm39)	R1046*	probably null	Het
Pom121l2	G	A	13: 22,166,297 (GRCm39)	W189*	probably null	Het
Prex2	C	A	1: 11,359,494 (GRCm39)	N1567K	probably damaging	Het
Prl	A	G	13: 27,245,472 (GRCm39)		probably null	Het
Ptpro	T	C	6: 137,369,739 (GRCm39)	V517A	probably damaging	Het
Rfwd3	C	T	8: 112,014,874 (GRCm39)	R326Q	probably damaging	Het
Tenm2	C	T	11: 35,954,004 (GRCm39)	G1236R	possibly damaging	Het
Vmn2r12	T	A	5: 109,239,763 (GRCm39)	I267F	probably damaging	Het
Wasf3	T	C	5: 146,388,786 (GRCm39)	V80A	probably damaging	Het

Other mutations in Lypd9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03073:Lypd9	APN	11	58,338,277 (GRCm39)	missense	probably damaging	0.96
R6188:Lypd9	UTSW	11	58,337,182 (GRCm39)	missense	probably benign	0.23
R6276:Lypd9	UTSW	11	58,337,192 (GRCm39)	missense	possibly damaging	0.51
R7633:Lypd9	UTSW	11	58,338,304 (GRCm39)	missense	probably benign	0.00
R7662:Lypd9	UTSW	11	58,338,269 (GRCm39)	missense	probably benign
R8819:Lypd9	UTSW	11	58,337,129 (GRCm39)	missense	probably damaging	0.99
R8820:Lypd9	UTSW	11	58,337,129 (GRCm39)	missense	probably damaging	0.99
R9008:Lypd9	UTSW	11	58,338,209 (GRCm39)	missense	probably benign
R9504:Lypd9	UTSW	11	58,337,215 (GRCm39)	missense	probably benign	0.23
Z1177:Lypd9	UTSW	11	58,337,100 (GRCm39)	missense	probably benign	0.23

Predicted Primers

PCR Primer
(F):5'- TGACTATGCTCTACGCCTTTCAACG -3'
(R):5'- ATCACTCTCTGCTCTGCCAAGGAC -3'

Sequencing Primer
(F):5'- GCCTTTCAACGTGCTTTTGG -3'
(R):5'- CTGCCTCATGACTGAGGATG -3'

Posted On

2014-01-29