Incidental Mutation 'R0024:Lysmd4'
ID15166
Institutional Source Beutler Lab
Gene Symbol Lysmd4
Ensembl Gene ENSMUSG00000043831
Gene NameLysM, putative peptidoglycan-binding, domain containing 4
Synonyms4930506D23Rik
MMRRC Submission 038319-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.085) question?
Stock #R0024 (G1)
Quality Score
Status Validated
Chromosome7
Chromosomal Location67222544-67307330 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 67226080 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 164 (T164A)
Ref Sequence ENSEMBL: ENSMUSP00000146557 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058771] [ENSMUST00000179106] [ENSMUST00000207757] [ENSMUST00000207823] [ENSMUST00000208213] [ENSMUST00000208512] [ENSMUST00000208698] [ENSMUST00000208998]
Predicted Effect probably benign
Transcript: ENSMUST00000058771
AA Change: T164A

PolyPhen 2 Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000053341
Gene: ENSMUSG00000043831
AA Change: T164A

DomainStartEndE-ValueType
low complexity region 31 43 N/A INTRINSIC
LysM 72 116 3.73e-4 SMART
transmembrane domain 215 237 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000179106
SMART Domains Protein: ENSMUSP00000136151
Gene: ENSMUSG00000043831

DomainStartEndE-ValueType
low complexity region 31 43 N/A INTRINSIC
LysM 72 116 3.73e-4 SMART
transmembrane domain 215 237 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181631
Predicted Effect probably benign
Transcript: ENSMUST00000207757
Predicted Effect probably benign
Transcript: ENSMUST00000207823
Predicted Effect probably benign
Transcript: ENSMUST00000208213
Predicted Effect probably benign
Transcript: ENSMUST00000208512
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208569
Predicted Effect probably benign
Transcript: ENSMUST00000208698
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208802
Predicted Effect probably benign
Transcript: ENSMUST00000208998
AA Change: T164A

PolyPhen 2 Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 79.2%
  • 3x: 69.7%
  • 10x: 44.0%
  • 20x: 23.5%
Validation Efficiency 95% (75/79)
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgre5 T C 8: 83,728,284 T260A probably damaging Het
Ahctf1 G A 1: 179,752,436 T2067M probably damaging Het
Akip1 T C 7: 109,704,138 S63P probably benign Het
Ankrd34c G A 9: 89,729,527 P254S possibly damaging Het
Aqp8 T C 7: 123,467,440 I256T probably benign Het
Arnt2 A G 7: 84,284,126 V308A probably benign Het
Astn1 G A 1: 158,684,215 S1209N probably damaging Het
Atf7ip T C 6: 136,599,820 probably benign Het
Bbx T A 16: 50,224,918 M427L probably benign Het
Cadm4 T C 7: 24,502,744 L336P probably benign Het
Camk2d A G 3: 126,797,723 M281V probably benign Het
Dll3 A G 7: 28,300,161 probably benign Het
Dscam G A 16: 96,593,385 R1906* probably null Het
Dst C T 1: 34,189,119 P1606L probably damaging Het
Eif2ak3 A G 6: 70,892,356 T676A probably benign Het
Entpd5 T C 12: 84,373,733 M428T probably benign Het
Fry T G 5: 150,380,803 S553A probably benign Het
Gls2 G A 10: 128,199,256 R86H probably damaging Het
Gm14340 T A 2: 180,824,250 noncoding transcript Het
Gm9457 A C 8: 4,813,131 noncoding transcript Het
Hfm1 T C 5: 106,856,924 K1179E probably benign Het
Iqgap1 T C 7: 80,751,939 T473A probably benign Het
Krt34 A T 11: 100,041,037 C119S probably benign Het
Krt6a A G 15: 101,690,715 probably benign Het
Mroh2b T A 15: 4,925,627 Y701N probably damaging Het
Pi4ka T C 16: 17,315,535 probably benign Het
Plcb1 A G 2: 135,362,425 S900G probably benign Het
Plxna2 T A 1: 194,643,995 I79N possibly damaging Het
Prpf31 C A 7: 3,636,659 probably null Het
Ptpro T A 6: 137,443,594 V1007D probably damaging Het
Rsc1a1 T C 4: 141,685,272 K110E probably benign Het
Sin3a T A 9: 57,118,253 probably benign Het
Slc24a2 T C 4: 87,028,240 probably benign Het
Slc6a3 A T 13: 73,540,837 probably benign Het
St5 T C 7: 109,524,659 H1131R probably damaging Het
Sugct G A 13: 16,857,869 H433Y probably benign Het
Sycp2l A G 13: 41,141,788 I310M probably damaging Het
Tpm3 C A 3: 90,087,449 probably null Het
Ttc27 T C 17: 74,770,264 F385L possibly damaging Het
Utrn A G 10: 12,406,011 V3301A probably benign Het
Other mutations in Lysmd4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02244:Lysmd4 APN 7 67225924 missense probably damaging 1.00
R0317:Lysmd4 UTSW 7 67226297 missense probably damaging 1.00
R0563:Lysmd4 UTSW 7 67226177 missense probably benign 0.01
R0653:Lysmd4 UTSW 7 67226040 missense probably benign 0.09
R1856:Lysmd4 UTSW 7 67226231 missense probably benign 0.07
R7012:Lysmd4 UTSW 7 67226017 missense probably benign 0.08
R7578:Lysmd4 UTSW 7 67226289 nonsense probably null
R7777:Lysmd4 UTSW 7 67223698 missense possibly damaging 0.92
Posted On2012-12-12