Mutagenetix > Incidental Mutation

Incidental Mutation 'R0024:Lysmd4'

15166

Institutional Source

Beutler Lab

Gene Symbol

Lysmd4

Ensembl Gene

ENSMUSG00000043831

Gene Name

LysM, putative peptidoglycan-binding, domain containing 4

Synonyms

4930506D23Rik

MMRRC Submission

038319-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

R0024 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

67222544-67307330 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 67226080 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 164 (T164A)

Ref Sequence

ENSEMBL: ENSMUSP00000146557 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000058771] [ENSMUST00000179106] [ENSMUST00000207757] [ENSMUST00000207823] [ENSMUST00000208213] [ENSMUST00000208512] [ENSMUST00000208698] [ENSMUST00000208998]

AlphaFold

Q8CC84

Predicted Effect

probably benign
Transcript: ENSMUST00000058771
AA Change: T164A

PolyPhen 2 Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000053341
Gene: ENSMUSG00000043831
AA Change: T164A

Domain	Start	End	E-Value	Type
low complexity region	31	43	N/A	INTRINSIC
LysM	72	116	3.73e-4	SMART
transmembrane domain	215	237	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000179106

SMART Domains

Protein: ENSMUSP00000136151
Gene: ENSMUSG00000043831

Domain	Start	End	E-Value	Type
low complexity region	31	43	N/A	INTRINSIC
LysM	72	116	3.73e-4	SMART
transmembrane domain	215	237	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000181631

Predicted Effect

probably benign
Transcript: ENSMUST00000207757

Predicted Effect

probably benign
Transcript: ENSMUST00000207823

Predicted Effect

probably benign
Transcript: ENSMUST00000208213

Predicted Effect

probably benign
Transcript: ENSMUST00000208512

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208569

Predicted Effect

probably benign
Transcript: ENSMUST00000208698

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208802

Predicted Effect

probably benign
Transcript: ENSMUST00000208998
AA Change: T164A

PolyPhen 2 Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 79.2%
3x: 69.7%
10x: 44.0%
20x: 23.5%

Validation Efficiency

95% (75/79)

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgre5	T	C	8: 83,728,284	T260A	probably damaging	Het
Ahctf1	G	A	1: 179,752,436	T2067M	probably damaging	Het
Akip1	T	C	7: 109,704,138	S63P	probably benign	Het
Ankrd34c	G	A	9: 89,729,527	P254S	possibly damaging	Het
Aqp8	T	C	7: 123,467,440	I256T	probably benign	Het
Arnt2	A	G	7: 84,284,126	V308A	probably benign	Het
Astn1	G	A	1: 158,684,215	S1209N	probably damaging	Het
Atf7ip	T	C	6: 136,599,820		probably benign	Het
Bbx	T	A	16: 50,224,918	M427L	probably benign	Het
Cadm4	T	C	7: 24,502,744	L336P	probably benign	Het
Camk2d	A	G	3: 126,797,723	M281V	probably benign	Het
Dll3	A	G	7: 28,300,161		probably benign	Het
Dscam	G	A	16: 96,593,385	R1906*	probably null	Het
Dst	C	T	1: 34,189,119	P1606L	probably damaging	Het
Eif2ak3	A	G	6: 70,892,356	T676A	probably benign	Het
Entpd5	T	C	12: 84,373,733	M428T	probably benign	Het
Fry	T	G	5: 150,380,803	S553A	probably benign	Het
Gls2	G	A	10: 128,199,256	R86H	probably damaging	Het
Gm14340	T	A	2: 180,824,250		noncoding transcript	Het
Gm9457	A	C	8: 4,813,131		noncoding transcript	Het
Hfm1	T	C	5: 106,856,924	K1179E	probably benign	Het
Iqgap1	T	C	7: 80,751,939	T473A	probably benign	Het
Krt34	A	T	11: 100,041,037	C119S	probably benign	Het
Krt6a	A	G	15: 101,690,715		probably benign	Het
Mroh2b	T	A	15: 4,925,627	Y701N	probably damaging	Het
Pi4ka	T	C	16: 17,315,535		probably benign	Het
Plcb1	A	G	2: 135,362,425	S900G	probably benign	Het
Plxna2	T	A	1: 194,643,995	I79N	possibly damaging	Het
Prpf31	C	A	7: 3,636,659		probably null	Het
Ptpro	T	A	6: 137,443,594	V1007D	probably damaging	Het
Rsc1a1	T	C	4: 141,685,272	K110E	probably benign	Het
Sin3a	T	A	9: 57,118,253		probably benign	Het
Slc24a2	T	C	4: 87,028,240		probably benign	Het
Slc6a3	A	T	13: 73,540,837		probably benign	Het
St5	T	C	7: 109,524,659	H1131R	probably damaging	Het
Sugct	G	A	13: 16,857,869	H433Y	probably benign	Het
Sycp2l	A	G	13: 41,141,788	I310M	probably damaging	Het
Tpm3	C	A	3: 90,087,449		probably null	Het
Ttc27	T	C	17: 74,770,264	F385L	possibly damaging	Het
Utrn	A	G	10: 12,406,011	V3301A	probably benign	Het

Other mutations in Lysmd4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02244:Lysmd4	APN	7	67225924	missense	probably damaging	1.00
R0317:Lysmd4	UTSW	7	67226297	missense	probably damaging	1.00
R0563:Lysmd4	UTSW	7	67226177	missense	probably benign	0.01
R0653:Lysmd4	UTSW	7	67226040	missense	probably benign	0.09
R1856:Lysmd4	UTSW	7	67226231	missense	probably benign	0.07
R7012:Lysmd4	UTSW	7	67226017	missense	probably benign	0.08
R7578:Lysmd4	UTSW	7	67226289	nonsense	probably null
R7777:Lysmd4	UTSW	7	67223698	missense	possibly damaging	0.92
R8064:Lysmd4	UTSW	7	67223650	missense	probably damaging	1.00
R8751:Lysmd4	UTSW	7	67226039	missense	probably benign	0.09
R8863:Lysmd4	UTSW	7	67223745	missense	probably damaging	0.97

Posted On

2012-12-12