Incidental Mutation 'R1250:Vmn1r31'
| ID |
151722 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r31
|
| Ensembl Gene |
ENSMUSG00000115404 |
| Gene Name |
vomeronasal 1 receptor 31 |
| Synonyms |
Gm6709 |
| MMRRC Submission |
039317-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.138)
|
| Stock # |
R1250 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
58448952-58449863 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 58449643 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 74
(V74A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153749
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000176023]
[ENSMUST00000176147]
[ENSMUST00000176177]
[ENSMUST00000177318]
[ENSMUST00000226390]
[ENSMUST00000228586]
|
| AlphaFold |
H3BKW5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176023
AA Change: V25A
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000135252
Gene: ENSMUSG00000115404
AA Change: V25A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
1 |
58 |
1.9e-14 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176147
AA Change: V25A
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000135282
Gene: ENSMUSG00000115404
AA Change: V25A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
1 |
58 |
1.9e-14 |
PFAM |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000135472
Gene: ENSMUSG00000093379
AA Change: V74A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
4.7e-56 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177318
AA Change: V74A
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000135555
Gene: ENSMUSG00000115404
AA Change: V74A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
107 |
1.9e-18 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000204999
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226390
AA Change: V74A
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228586
AA Change: V74A
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.6%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 19 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aptx |
T |
A |
4: 40,693,447 (GRCm39) |
E162D |
probably benign |
Het |
| Cdhr4 |
A |
T |
9: 107,874,715 (GRCm39) |
Q20L |
probably damaging |
Het |
| Dlk1 |
A |
T |
12: 109,425,744 (GRCm39) |
T206S |
probably damaging |
Het |
| Gabrr2 |
T |
C |
4: 33,063,273 (GRCm39) |
L32P |
probably benign |
Het |
| Gjb3 |
G |
A |
4: 127,220,224 (GRCm39) |
R103W |
probably damaging |
Het |
| Kntc1 |
T |
A |
5: 123,922,262 (GRCm39) |
S954T |
possibly damaging |
Het |
| Krt28 |
A |
G |
11: 99,257,648 (GRCm39) |
|
probably null |
Het |
| Lingo3 |
T |
C |
10: 80,670,605 (GRCm39) |
T442A |
probably benign |
Het |
| Map3k5 |
G |
A |
10: 19,986,521 (GRCm39) |
A912T |
possibly damaging |
Het |
| Msantd3 |
C |
A |
4: 48,552,789 (GRCm39) |
P126Q |
probably damaging |
Het |
| Nek10 |
T |
C |
14: 14,853,887 (GRCm38) |
S358P |
probably damaging |
Het |
| Prl2c2 |
G |
C |
13: 13,176,786 (GRCm39) |
T47R |
probably damaging |
Het |
| Prss59 |
A |
T |
6: 40,902,909 (GRCm39) |
|
probably null |
Het |
| Qtrt1 |
C |
T |
9: 21,330,844 (GRCm39) |
T324M |
probably benign |
Het |
| Rag2 |
A |
G |
2: 101,460,784 (GRCm39) |
S365G |
probably damaging |
Het |
| Slc6a2 |
C |
A |
8: 93,719,491 (GRCm39) |
T402K |
probably benign |
Het |
| Slc9b1 |
T |
C |
3: 135,054,531 (GRCm39) |
M1T |
probably null |
Het |
| Ttn |
A |
G |
2: 76,720,904 (GRCm39) |
|
probably benign |
Het |
| Zkscan3 |
A |
G |
13: 21,572,694 (GRCm39) |
F313L |
probably benign |
Het |
|
| Other mutations in Vmn1r31 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01326:Vmn1r31
|
APN |
6 |
58,449,784 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01386:Vmn1r31
|
APN |
6 |
58,449,587 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL01785:Vmn1r31
|
APN |
6 |
58,449,709 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02527:Vmn1r31
|
APN |
6 |
58,449,778 (GRCm39) |
missense |
probably benign |
0.01 |
|
PIT4791001:Vmn1r31
|
UTSW |
6 |
58,449,028 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0107:Vmn1r31
|
UTSW |
6 |
58,449,728 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1616:Vmn1r31
|
UTSW |
6 |
58,449,043 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1883:Vmn1r31
|
UTSW |
6 |
58,449,029 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1884:Vmn1r31
|
UTSW |
6 |
58,449,029 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2942:Vmn1r31
|
UTSW |
6 |
58,449,583 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4589:Vmn1r31
|
UTSW |
6 |
58,449,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4672:Vmn1r31
|
UTSW |
6 |
58,449,056 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4676:Vmn1r31
|
UTSW |
6 |
58,448,998 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4702:Vmn1r31
|
UTSW |
6 |
58,448,953 (GRCm39) |
makesense |
probably null |
|
|
R4703:Vmn1r31
|
UTSW |
6 |
58,448,953 (GRCm39) |
makesense |
probably null |
|
|
R4705:Vmn1r31
|
UTSW |
6 |
58,448,953 (GRCm39) |
makesense |
probably null |
|
|
R6341:Vmn1r31
|
UTSW |
6 |
58,448,995 (GRCm39) |
missense |
probably benign |
0.35 |
|
R6549:Vmn1r31
|
UTSW |
6 |
58,449,648 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7238:Vmn1r31
|
UTSW |
6 |
58,449,858 (GRCm39) |
missense |
|
|
|
R7609:Vmn1r31
|
UTSW |
6 |
58,449,455 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8438:Vmn1r31
|
UTSW |
6 |
58,449,646 (GRCm39) |
missense |
|
|
|
R8936:Vmn1r31
|
UTSW |
6 |
58,449,083 (GRCm39) |
missense |
unknown |
|
|
R9103:Vmn1r31
|
UTSW |
6 |
58,449,073 (GRCm39) |
missense |
unknown |
|
|
Z1176:Vmn1r31
|
UTSW |
6 |
58,449,376 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGCCTCTGATGTCTGCACAAGATAATC -3'
(R):5'- CTGGACTTGGAGCCTTAGCCAATATG -3'
Sequencing Primer
(F):5'- AGGATTCAGTGACCTGCATC -3'
(R):5'- GAGCCTTAGCCAATATGTTTCTTC -3'
|
| Posted On |
2014-01-29 |
Incidental Mutation