Incidental Mutation 'R1252:Zfp946'
ID 151821
Institutional Source Beutler Lab
Gene Symbol Zfp946
Ensembl Gene ENSMUSG00000071266
Gene Name zinc finger protein 946
Synonyms 1300003B13Rik
MMRRC Submission 039319-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R1252 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 22643203-22675670 bp(+) (GRCm39)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) G to T at 22672560 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000132940 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088763] [ENSMUST00000120222] [ENSMUST00000167740]
AlphaFold F6VWU8
Predicted Effect probably null
Transcript: ENSMUST00000088763
SMART Domains Protein: ENSMUSP00000086141
Gene: ENSMUSG00000071266

DomainStartEndE-ValueType
KRAB 13 71 4.49e-17 SMART
ZnF_C2H2 186 208 3.83e-2 SMART
ZnF_C2H2 242 264 1.6e-4 SMART
ZnF_C2H2 270 292 1.45e-2 SMART
ZnF_C2H2 298 320 5.99e-4 SMART
ZnF_C2H2 326 348 2.15e-5 SMART
ZnF_C2H2 354 376 2.4e-3 SMART
ZnF_C2H2 382 404 1.28e-3 SMART
ZnF_C2H2 410 432 2.09e-3 SMART
ZnF_C2H2 438 460 9.44e-2 SMART
ZnF_C2H2 466 488 3.44e-4 SMART
ZnF_C2H2 494 516 1.5e-4 SMART
Predicted Effect probably null
Transcript: ENSMUST00000120222
SMART Domains Protein: ENSMUSP00000113244
Gene: ENSMUSG00000071266

DomainStartEndE-ValueType
KRAB 13 71 4.49e-17 SMART
ZnF_C2H2 186 208 3.83e-2 SMART
ZnF_C2H2 242 264 1.6e-4 SMART
ZnF_C2H2 270 292 1.45e-2 SMART
ZnF_C2H2 298 320 5.99e-4 SMART
ZnF_C2H2 326 348 2.15e-5 SMART
ZnF_C2H2 354 376 2.4e-3 SMART
ZnF_C2H2 382 404 1.28e-3 SMART
ZnF_C2H2 410 432 2.09e-3 SMART
ZnF_C2H2 438 460 9.44e-2 SMART
ZnF_C2H2 466 488 3.44e-4 SMART
ZnF_C2H2 494 516 1.5e-4 SMART
Predicted Effect probably null
Transcript: ENSMUST00000167740
SMART Domains Protein: ENSMUSP00000132940
Gene: ENSMUSG00000071266

DomainStartEndE-ValueType
KRAB 13 71 4.49e-17 SMART
ZnF_C2H2 186 208 3.83e-2 SMART
ZnF_C2H2 242 264 1.6e-4 SMART
ZnF_C2H2 270 292 1.45e-2 SMART
ZnF_C2H2 298 320 5.99e-4 SMART
ZnF_C2H2 326 348 2.15e-5 SMART
ZnF_C2H2 354 376 2.4e-3 SMART
ZnF_C2H2 382 404 1.28e-3 SMART
ZnF_C2H2 410 432 2.09e-3 SMART
ZnF_C2H2 438 460 9.44e-2 SMART
ZnF_C2H2 466 488 3.44e-4 SMART
ZnF_C2H2 494 516 1.5e-4 SMART
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.6%
  • 20x: 90.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb10 C T 8: 124,688,791 (GRCm39) G495D probably damaging Het
Acsm2 C T 7: 119,172,468 (GRCm39) H104Y probably benign Het
Adgrb3 G A 1: 25,167,909 (GRCm39) T1009M probably damaging Het
Arfgef2 A G 2: 166,701,877 (GRCm39) K755E probably damaging Het
Atm A T 9: 53,367,140 (GRCm39) D2491E probably damaging Het
Bptf A G 11: 106,964,077 (GRCm39) S1706P probably benign Het
Capn13 C T 17: 73,674,222 (GRCm39) G77D possibly damaging Het
Ccdc39 T C 3: 33,880,629 (GRCm39) K446R probably damaging Het
Cdhr18 T C 14: 13,862,444 (GRCm38) D370G probably benign Het
Cep135 A G 5: 76,741,962 (GRCm39) K133E possibly damaging Het
Cyp2c67 A G 19: 39,614,585 (GRCm39) M314T possibly damaging Het
Dennd5b T C 6: 148,945,985 (GRCm39) D542G probably damaging Het
Dpys A T 15: 39,687,636 (GRCm39) N387K probably damaging Het
Erc1 A T 6: 119,720,353 (GRCm39) D749E possibly damaging Het
Gucy2e A T 11: 69,126,485 (GRCm39) F298L probably benign Het
Igsf10 A G 3: 59,239,269 (GRCm39) V304A probably benign Het
Kmt2b A T 7: 30,279,912 (GRCm39) C1363S probably damaging Het
Krt87 A G 15: 101,385,711 (GRCm39) Y295H probably damaging Het
Lmo7 T C 14: 102,138,019 (GRCm39) V396A probably damaging Het
Lpl A G 8: 69,345,311 (GRCm39) D105G probably benign Het
Lrrc45 C A 11: 120,606,297 (GRCm39) T135N probably benign Het
Ltn1 C T 16: 87,212,918 (GRCm39) A548T probably benign Het
Nectin2 T G 7: 19,451,523 (GRCm39) I504L probably benign Het
Nmbr T C 10: 14,636,187 (GRCm39) I52T probably benign Het
Nop14 A T 5: 34,807,899 (GRCm39) N354K probably benign Het
Olfm1 A G 2: 28,119,447 (GRCm39) I361V probably benign Het
Or8g18 G C 9: 39,149,547 (GRCm39) P58A probably benign Het
Ovol1 T C 19: 5,603,629 (GRCm39) T91A probably benign Het
Pigz T A 16: 31,760,808 (GRCm39) V3E possibly damaging Het
Pip4k2b T C 11: 97,635,420 (GRCm39) N4S probably benign Het
Slc23a2 A T 2: 131,904,117 (GRCm39) probably null Het
Slc66a2 A G 18: 80,334,813 (GRCm39) T211A possibly damaging Het
Speg A T 1: 75,403,739 (GRCm39) D2640V probably damaging Het
Trip12 G A 1: 84,754,071 (GRCm39) Q111* probably null Het
Trub2 A G 2: 29,672,170 (GRCm39) F141S probably damaging Het
Ugcg C T 4: 59,207,798 (GRCm39) P46S probably benign Het
Wdfy4 A T 14: 32,693,729 (GRCm39) probably null Het
Zfp935 A G 13: 62,602,355 (GRCm39) F282L probably damaging Het
Zkscan4 A G 13: 21,668,044 (GRCm39) E165G probably benign Het
Other mutations in Zfp946
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01548:Zfp946 APN 17 22,673,643 (GRCm39) missense possibly damaging 0.88
IGL01869:Zfp946 APN 17 22,673,684 (GRCm39) missense probably benign 0.45
IGL02037:Zfp946 APN 17 22,672,469 (GRCm39) missense probably damaging 1.00
IGL03111:Zfp946 APN 17 22,673,537 (GRCm39) missense possibly damaging 0.76
R0324:Zfp946 UTSW 17 22,673,417 (GRCm39) missense probably benign 0.41
R1733:Zfp946 UTSW 17 22,672,538 (GRCm39) missense probably damaging 1.00
R1971:Zfp946 UTSW 17 22,674,406 (GRCm39) missense probably damaging 1.00
R2064:Zfp946 UTSW 17 22,674,446 (GRCm39) missense probably damaging 1.00
R2106:Zfp946 UTSW 17 22,672,466 (GRCm39) missense probably benign 0.30
R2216:Zfp946 UTSW 17 22,673,697 (GRCm39) missense possibly damaging 0.49
R3899:Zfp946 UTSW 17 22,673,531 (GRCm39) missense probably benign 0.05
R3924:Zfp946 UTSW 17 22,674,682 (GRCm39) missense probably benign 0.06
R4125:Zfp946 UTSW 17 22,673,548 (GRCm39) nonsense probably null
R4493:Zfp946 UTSW 17 22,670,067 (GRCm39) splice site probably null
R4694:Zfp946 UTSW 17 22,674,692 (GRCm39) missense probably benign 0.16
R4924:Zfp946 UTSW 17 22,674,502 (GRCm39) missense probably damaging 1.00
R4939:Zfp946 UTSW 17 22,674,418 (GRCm39) missense probably damaging 1.00
R5020:Zfp946 UTSW 17 22,674,584 (GRCm39) missense probably benign 0.03
R5248:Zfp946 UTSW 17 22,673,447 (GRCm39) missense probably benign 0.12
R5547:Zfp946 UTSW 17 22,673,873 (GRCm39) missense probably benign 0.00
R5551:Zfp946 UTSW 17 22,674,365 (GRCm39) missense probably damaging 1.00
R5573:Zfp946 UTSW 17 22,673,676 (GRCm39) nonsense probably null
R6048:Zfp946 UTSW 17 22,673,821 (GRCm39) missense probably benign 0.03
R6080:Zfp946 UTSW 17 22,674,090 (GRCm39) missense probably benign 0.00
R6198:Zfp946 UTSW 17 22,673,896 (GRCm39) missense probably damaging 1.00
R6332:Zfp946 UTSW 17 22,673,519 (GRCm39) missense probably damaging 1.00
R6766:Zfp946 UTSW 17 22,674,752 (GRCm39) missense probably benign 0.01
R7132:Zfp946 UTSW 17 22,673,644 (GRCm39) missense probably benign 0.41
R7248:Zfp946 UTSW 17 22,672,489 (GRCm39) nonsense probably null
R7695:Zfp946 UTSW 17 22,674,002 (GRCm39) missense probably benign 0.05
R8113:Zfp946 UTSW 17 22,674,481 (GRCm39) missense probably damaging 1.00
R9380:Zfp946 UTSW 17 22,673,680 (GRCm39) missense probably benign 0.06
R9408:Zfp946 UTSW 17 22,673,569 (GRCm39) missense possibly damaging 0.83
X0065:Zfp946 UTSW 17 22,674,494 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- ACCTTGTCTGTATAAGAGCACCCTGG -3'
(R):5'- GGGACACTGTGTAGCTTTGGTCATC -3'

Sequencing Primer
(F):5'- TCTGTATAAGAGCACCCTGGAAAAC -3'
(R):5'- GAATACAACACTGGATCTTCTTCC -3'
Posted On 2014-01-29