Incidental Mutation 'R1245:Gpr137c'
| ID |
152137 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Gpr137c
|
| Ensembl Gene |
ENSMUSG00000049092 |
| Gene Name |
G protein-coupled receptor 137C |
| Synonyms |
TM7SF1L2, LOC380893, 6330416L11Rik |
| MMRRC Submission |
039312-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.074)
|
| Stock # |
R1245 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
14 |
| Chromosomal Location |
45457174-45520182 bp(+) (GRCm39) |
| Type of Mutation |
utr 3 prime |
| DNA Base Change (assembly) |
T to C
at 45516522 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154701
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000022378]
[ENSMUST00000146150]
[ENSMUST00000151749]
|
| AlphaFold |
E9Q343 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000022378
|
| SMART Domains |
Protein: ENSMUSP00000022378
Gene: ENSMUSG00000021831
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
21 |
N/A |
INTRINSIC |
|
Pfam:ERO1
|
60 |
453 |
3.7e-128 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000146150
|
| SMART Domains |
Protein: ENSMUSP00000120015
Gene: ENSMUSG00000049092
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
4 |
17 |
N/A |
INTRINSIC |
|
low complexity region
|
23 |
39 |
N/A |
INTRINSIC |
|
transmembrane domain
|
44 |
66 |
N/A |
INTRINSIC |
|
transmembrane domain
|
78 |
100 |
N/A |
INTRINSIC |
|
Blast:G_alpha
|
121 |
286 |
9e-17 |
BLAST |
|
transmembrane domain
|
294 |
316 |
N/A |
INTRINSIC |
|
low complexity region
|
376 |
389 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000151749
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000227166
|
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.2%
- 10x: 95.9%
- 20x: 91.5%
|
| Validation Efficiency |
98% (41/42) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 38 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adcy1 |
T |
A |
11: 7,119,410 (GRCm39) |
|
probably benign |
Het |
| Ahnak |
A |
G |
19: 8,981,533 (GRCm39) |
N939S |
probably benign |
Het |
| Cblb |
C |
A |
16: 51,867,550 (GRCm39) |
|
probably benign |
Het |
| Cd22 |
A |
G |
7: 30,569,308 (GRCm39) |
S603P |
probably damaging |
Het |
| Col6a6 |
G |
A |
9: 105,626,109 (GRCm39) |
R1515C |
possibly damaging |
Het |
| Csf1r |
C |
A |
18: 61,247,884 (GRCm39) |
D317E |
probably benign |
Het |
| Dlg2 |
T |
C |
7: 92,091,803 (GRCm39) |
|
probably benign |
Het |
| Enpp3 |
G |
A |
10: 24,660,851 (GRCm39) |
|
probably benign |
Het |
| G530012D18Rik |
CAGAGAGA |
CAGAGAGAGA |
1: 85,504,945 (GRCm39) |
|
probably null |
Het |
| Gm5828 |
A |
T |
1: 16,839,353 (GRCm39) |
|
noncoding transcript |
Het |
| Ibtk |
A |
G |
9: 85,602,795 (GRCm39) |
|
probably null |
Het |
| Kctd7 |
A |
G |
5: 130,177,058 (GRCm39) |
H96R |
possibly damaging |
Het |
| Lmcd1 |
T |
A |
6: 112,292,673 (GRCm39) |
V175E |
probably benign |
Het |
| Lrfn2 |
A |
T |
17: 49,403,277 (GRCm39) |
|
probably null |
Het |
| Ltbp1 |
C |
T |
17: 75,634,189 (GRCm39) |
|
probably benign |
Het |
| Myc |
A |
G |
15: 61,859,746 (GRCm39) |
I140V |
probably damaging |
Het |
| Nckap1l |
A |
G |
15: 103,364,352 (GRCm39) |
E100G |
probably damaging |
Het |
| Ncs1 |
A |
G |
2: 31,174,705 (GRCm39) |
N143S |
probably benign |
Het |
| Nmnat2 |
A |
G |
1: 152,987,949 (GRCm39) |
D238G |
probably benign |
Het |
| Or10ag57 |
T |
A |
2: 87,218,553 (GRCm39) |
V168E |
probably benign |
Het |
| Ppp2r3d |
G |
A |
9: 101,071,593 (GRCm39) |
T675I |
probably damaging |
Het |
| Psma2 |
A |
G |
13: 14,787,876 (GRCm39) |
Y6C |
probably damaging |
Het |
| Rspo4 |
G |
A |
2: 151,709,846 (GRCm39) |
E84K |
probably damaging |
Het |
| Shank2 |
G |
A |
7: 143,965,457 (GRCm39) |
V1015I |
probably benign |
Het |
| Slc35e1 |
T |
C |
8: 73,246,415 (GRCm39) |
|
probably benign |
Het |
| Smg8 |
T |
C |
11: 86,974,436 (GRCm39) |
D632G |
possibly damaging |
Het |
| Sppl2a |
A |
T |
2: 126,755,441 (GRCm39) |
|
probably benign |
Het |
| Svep1 |
A |
G |
4: 58,066,427 (GRCm39) |
|
probably null |
Het |
| Ttn |
T |
A |
2: 76,776,044 (GRCm39) |
K1666M |
probably damaging |
Het |
| Ulk1 |
A |
G |
5: 110,937,206 (GRCm39) |
|
probably null |
Het |
| Unc80 |
A |
G |
1: 66,594,254 (GRCm39) |
D1211G |
possibly damaging |
Het |
| Vmn2r112 |
A |
G |
17: 22,822,228 (GRCm39) |
Q302R |
probably benign |
Het |
| Vmn2r6 |
A |
G |
3: 64,464,211 (GRCm39) |
S208P |
possibly damaging |
Het |
| Wnk1 |
C |
T |
6: 119,925,418 (GRCm39) |
V1847I |
probably benign |
Het |
| Zfp653 |
A |
T |
9: 21,967,718 (GRCm39) |
I529N |
probably damaging |
Het |
| Zfp948 |
T |
C |
17: 21,807,104 (GRCm39) |
S99P |
probably damaging |
Het |
| Zfyve9 |
A |
G |
4: 108,550,508 (GRCm39) |
|
probably benign |
Het |
| Zscan29 |
T |
C |
2: 120,996,984 (GRCm39) |
T246A |
probably damaging |
Het |
|
| Other mutations in Gpr137c |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00478:Gpr137c
|
APN |
14 |
45,516,202 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02167:Gpr137c
|
APN |
14 |
45,517,412 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02203:Gpr137c
|
APN |
14 |
45,514,944 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02960:Gpr137c
|
APN |
14 |
45,483,890 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0731:Gpr137c
|
UTSW |
14 |
45,483,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1162:Gpr137c
|
UTSW |
14 |
45,481,615 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1983:Gpr137c
|
UTSW |
14 |
45,517,428 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2060:Gpr137c
|
UTSW |
14 |
45,481,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2428:Gpr137c
|
UTSW |
14 |
45,516,420 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3034:Gpr137c
|
UTSW |
14 |
45,457,733 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3911:Gpr137c
|
UTSW |
14 |
45,516,392 (GRCm39) |
missense |
probably benign |
0.31 |
|
R4037:Gpr137c
|
UTSW |
14 |
45,457,687 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4038:Gpr137c
|
UTSW |
14 |
45,457,687 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4213:Gpr137c
|
UTSW |
14 |
45,483,965 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4986:Gpr137c
|
UTSW |
14 |
45,483,743 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5521:Gpr137c
|
UTSW |
14 |
45,516,151 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6028:Gpr137c
|
UTSW |
14 |
45,514,938 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7117:Gpr137c
|
UTSW |
14 |
45,516,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7238:Gpr137c
|
UTSW |
14 |
45,516,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7365:Gpr137c
|
UTSW |
14 |
45,516,471 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9515:Gpr137c
|
UTSW |
14 |
45,516,229 (GRCm39) |
nonsense |
probably null |
|
|
R9539:Gpr137c
|
UTSW |
14 |
45,516,187 (GRCm39) |
missense |
probably damaging |
0.97 |
|
X0027:Gpr137c
|
UTSW |
14 |
45,516,126 (GRCm39) |
missense |
probably benign |
0.14 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACCCAGTCTTTAATGCTGTGTCCAC -3'
(R):5'- AGCAATCCTTCCATGCCTGTCAAC -3'
Sequencing Primer
(F):5'- CTGTGTCCACAGGCACC -3'
(R):5'- ATGCTCTGACTCTGAACCGAG -3'
|
| Posted On |
2014-01-29 |
Incidental Mutation