Mutagenetix > Incidental Mutation

Incidental Mutation 'R1245:Vmn2r112'

152142

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r112

Ensembl Gene

ENSMUSG00000094921

Gene Name

vomeronasal 2, receptor 112

Synonyms

EG628185

MMRRC Submission

039312-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.111) question?

Stock #

R1245 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

22601148-22619133 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 22603247 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Arginine at position 302 (Q302R)

Ref Sequence

ENSEMBL: ENSMUSP00000094994 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000097381]

AlphaFold

L7N221

Predicted Effect

probably benign
Transcript: ENSMUST00000097381
AA Change: Q302R

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000094994
Gene: ENSMUSG00000094921
AA Change: Q302R

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	471	2.8e-32	PFAM
Pfam:NCD3G	512	565	5.8e-21	PFAM
Pfam:7tm_3	598	833	6.5e-54	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.0%
3x: 98.2%
10x: 95.9%
20x: 91.5%

Validation Efficiency

98% (41/42)

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adcy1	T	A	11: 7,169,410		probably benign	Het
Ahnak	A	G	19: 9,004,169	N939S	probably benign	Het
Cblb	C	A	16: 52,047,187		probably benign	Het
Cd22	A	G	7: 30,869,883	S603P	probably damaging	Het
Col6a6	G	A	9: 105,748,910	R1515C	possibly damaging	Het
Csf1r	C	A	18: 61,114,812	D317E	probably benign	Het
Dlg2	T	C	7: 92,442,595		probably benign	Het
Enpp3	G	A	10: 24,784,953		probably benign	Het
G530012D18Rik	CAGAGAGA	CAGAGAGAGA	1: 85,577,224		probably null	Het
Gm5828	A	T	1: 16,769,129		noncoding transcript	Het
Gpr137c	T	C	14: 45,279,065		probably benign	Het
Ibtk	A	G	9: 85,720,742		probably null	Het
Kctd7	A	G	5: 130,148,217	H96R	possibly damaging	Het
Lmcd1	T	A	6: 112,315,712	V175E	probably benign	Het
Lrfn2	A	T	17: 49,096,249		probably null	Het
Ltbp1	C	T	17: 75,327,194		probably benign	Het
Myc	A	G	15: 61,987,897	I140V	probably damaging	Het
Nckap1l	A	G	15: 103,455,925	E100G	probably damaging	Het
Ncs1	A	G	2: 31,284,693	N143S	probably benign	Het
Nmnat2	A	G	1: 153,112,203	D238G	probably benign	Het
Olfr1122	T	A	2: 87,388,209	V168E	probably benign	Het
Ppp2r3a	G	A	9: 101,194,394	T675I	probably damaging	Het
Psma2	A	G	13: 14,613,291	Y6C	probably damaging	Het
Rspo4	G	A	2: 151,867,926	E84K	probably damaging	Het
Shank2	G	A	7: 144,411,720	V1015I	probably benign	Het
Slc35e1	T	C	8: 72,492,571		probably benign	Het
Smg8	T	C	11: 87,083,610	D632G	possibly damaging	Het
Sppl2a	A	T	2: 126,913,521		probably benign	Het
Svep1	A	G	4: 58,066,427		probably null	Het
Ttn	T	A	2: 76,945,700	K1666M	probably damaging	Het
Ulk1	A	G	5: 110,789,340		probably null	Het
Unc80	A	G	1: 66,555,095	D1211G	possibly damaging	Het
Vmn2r6	A	G	3: 64,556,790	S208P	possibly damaging	Het
Wnk1	C	T	6: 119,948,457	V1847I	probably benign	Het
Zfp653	A	T	9: 22,056,422	I529N	probably damaging	Het
Zfp948	T	C	17: 21,586,842	S99P	probably damaging	Het
Zfyve9	A	G	4: 108,693,311		probably benign	Het
Zscan29	T	C	2: 121,166,503	T246A	probably damaging	Het

Other mutations in Vmn2r112

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00341:Vmn2r112	APN	17	22,618,936 (GRCm38)	missense	probably benign	0.13
IGL01021:Vmn2r112	APN	17	22,618,904 (GRCm38)	missense	probably damaging	1.00
IGL01122:Vmn2r112	APN	17	22,603,007 (GRCm38)	missense	probably benign	0.00
IGL01360:Vmn2r112	APN	17	22,618,622 (GRCm38)	missense	probably benign	0.03
IGL01536:Vmn2r112	APN	17	22,605,155 (GRCm38)	missense	probably damaging	1.00
IGL02148:Vmn2r112	APN	17	22,619,032 (GRCm38)	missense	probably damaging	1.00
IGL02465:Vmn2r112	APN	17	22,614,994 (GRCm38)	missense	probably damaging	1.00
PIT4576001:Vmn2r112	UTSW	17	22,614,931 (GRCm38)	missense	probably benign	0.00
R0278:Vmn2r112	UTSW	17	22,603,006 (GRCm38)	missense	probably benign	0.44
R0328:Vmn2r112	UTSW	17	22,605,270 (GRCm38)	missense	probably benign	0.01
R0583:Vmn2r112	UTSW	17	22,618,949 (GRCm38)	missense	probably damaging	1.00
R0831:Vmn2r112	UTSW	17	22,614,999 (GRCm38)	missense	probably damaging	0.99
R1080:Vmn2r112	UTSW	17	22,618,999 (GRCm38)	missense	probably damaging	1.00
R1321:Vmn2r112	UTSW	17	22,618,519 (GRCm38)	nonsense	probably null
R1381:Vmn2r112	UTSW	17	22,618,486 (GRCm38)	missense	probably damaging	1.00
R1514:Vmn2r112	UTSW	17	22,602,844 (GRCm38)	missense	probably benign	0.40
R1519:Vmn2r112	UTSW	17	22,618,903 (GRCm38)	missense	possibly damaging	0.83
R1572:Vmn2r112	UTSW	17	22,603,144 (GRCm38)	missense	possibly damaging	0.61
R1590:Vmn2r112	UTSW	17	22,615,008 (GRCm38)	critical splice donor site	probably null
R1640:Vmn2r112	UTSW	17	22,605,116 (GRCm38)	missense	probably benign	0.01
R2221:Vmn2r112	UTSW	17	22,601,233 (GRCm38)	missense	possibly damaging	0.86
R2223:Vmn2r112	UTSW	17	22,601,233 (GRCm38)	missense	possibly damaging	0.86
R2310:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R2312:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R2337:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R2339:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R2340:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R2341:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R2342:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R2401:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R2860:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R2861:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R2926:Vmn2r112	UTSW	17	22,615,003 (GRCm38)	missense	possibly damaging	0.90
R3236:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R3237:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R3977:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R3979:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R4168:Vmn2r112	UTSW	17	22,603,088 (GRCm38)	missense	probably benign	0.01
R4256:Vmn2r112	UTSW	17	22,618,412 (GRCm38)	missense	probably damaging	1.00
R4386:Vmn2r112	UTSW	17	22,601,322 (GRCm38)	missense	probably benign	0.36
R4912:Vmn2r112	UTSW	17	22,603,382 (GRCm38)	missense	probably damaging	0.99
R4947:Vmn2r112	UTSW	17	22,602,879 (GRCm38)	missense	probably benign	0.02
R5446:Vmn2r112	UTSW	17	22,618,250 (GRCm38)	missense	probably damaging	1.00
R5870:Vmn2r112	UTSW	17	22,619,023 (GRCm38)	missense	probably benign	0.00
R6351:Vmn2r112	UTSW	17	22,601,278 (GRCm38)	missense	probably benign
R6384:Vmn2r112	UTSW	17	22,605,155 (GRCm38)	missense	probably damaging	1.00
R6390:Vmn2r112	UTSW	17	22,605,249 (GRCm38)	missense	probably benign	0.01
R6401:Vmn2r112	UTSW	17	22,603,551 (GRCm38)	nonsense	probably null
R6405:Vmn2r112	UTSW	17	22,618,235 (GRCm38)	missense	probably damaging	1.00
R6620:Vmn2r112	UTSW	17	22,603,101 (GRCm38)	missense	probably benign	0.00
R6648:Vmn2r112	UTSW	17	22,618,486 (GRCm38)	missense	probably damaging	1.00
R6649:Vmn2r112	UTSW	17	22,601,179 (GRCm38)	missense	probably null	1.00
R6653:Vmn2r112	UTSW	17	22,601,179 (GRCm38)	missense	probably null	1.00
R6654:Vmn2r112	UTSW	17	22,603,469 (GRCm38)	missense	possibly damaging	0.89
R6700:Vmn2r112	UTSW	17	22,603,481 (GRCm38)	missense	possibly damaging	0.53
R6993:Vmn2r112	UTSW	17	22,603,214 (GRCm38)	missense	probably benign	0.01
R7052:Vmn2r112	UTSW	17	22,602,526 (GRCm38)	missense	probably benign
R7454:Vmn2r112	UTSW	17	22,603,307 (GRCm38)	missense	probably benign	0.00
R7763:Vmn2r112	UTSW	17	22,603,118 (GRCm38)	missense	probably damaging	1.00
R8032:Vmn2r112	UTSW	17	22,603,394 (GRCm38)	missense	probably benign	0.21
R8177:Vmn2r112	UTSW	17	22,603,613 (GRCm38)	missense	possibly damaging	0.47
R8263:Vmn2r112	UTSW	17	22,605,159 (GRCm38)	missense	probably damaging	1.00
R8395:Vmn2r112	UTSW	17	22,618,606 (GRCm38)	missense	possibly damaging	0.94
R8492:Vmn2r112	UTSW	17	22,602,489 (GRCm38)	missense	probably benign	0.03
R8889:Vmn2r112	UTSW	17	22,618,631 (GRCm38)	missense	probably damaging	1.00
R8892:Vmn2r112	UTSW	17	22,618,631 (GRCm38)	missense	probably damaging	1.00
R9246:Vmn2r112	UTSW	17	22,605,107 (GRCm38)	missense	probably benign	0.21
R9269:Vmn2r112	UTSW	17	22,601,232 (GRCm38)	missense	probably benign
R9273:Vmn2r112	UTSW	17	22,618,740 (GRCm38)	missense	probably damaging	1.00
R9288:Vmn2r112	UTSW	17	22,603,342 (GRCm38)	missense	probably damaging	1.00
R9352:Vmn2r112	UTSW	17	22,603,498 (GRCm38)	missense	probably damaging	0.98
R9406:Vmn2r112	UTSW	17	22,605,242 (GRCm38)	nonsense	probably null
R9432:Vmn2r112	UTSW	17	22,602,252 (GRCm38)	missense
R9728:Vmn2r112	UTSW	17	22,605,127 (GRCm38)	missense	probably damaging	0.96
Z1088:Vmn2r112	UTSW	17	22,605,078 (GRCm38)	missense	possibly damaging	0.89

Predicted Primers

PCR Primer
(F):5'- ATCTCTTGTGCCAGCATGGCCTTG -3'
(R):5'- AGTGCATCCATTCCAGCTCTACCAG -3'

Sequencing Primer
(F):5'- TGGTCATCTCAGACAGTGATCAAG -3'
(R):5'- CAGATATTCATCTGGGCATTTGACTG -3'

Posted On

2014-01-29