Incidental Mutation 'R1248:Vmn2r16'
ID 152183
Institutional Source Beutler Lab
Gene Symbol Vmn2r16
Ensembl Gene ENSMUSG00000092080
Gene Name vomeronasal 2, receptor 16
Synonyms EG384220
MMRRC Submission 039315-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.154) question?
Stock # R1248 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 109478247-109512347 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 109508643 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 457 (N457S)
Ref Sequence ENSEMBL: ENSMUSP00000127838 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165180]
AlphaFold A0A3B2WCY4
Predicted Effect probably benign
Transcript: ENSMUST00000165180
AA Change: N457S

PolyPhen 2 Score 0.103 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000127838
Gene: ENSMUSG00000092080
AA Change: N457S

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 76 425 2.3e-28 PFAM
Pfam:NCD3G 509 563 8.2e-19 PFAM
Pfam:7tm_3 596 831 3.5e-56 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.6%
  • 20x: 90.5%
Validation Efficiency 98% (43/44)
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgb A T 10: 10,271,054 (GRCm39) F863Y probably damaging Het
Akap12 A G 10: 4,303,847 (GRCm39) E219G probably benign Het
Akr1c20 G A 13: 4,564,399 (GRCm39) T38I possibly damaging Het
Ap5z1 C A 5: 142,460,255 (GRCm39) S511R probably benign Het
Arhgap11a T A 2: 113,664,447 (GRCm39) H612L possibly damaging Het
Atp2b2 G T 6: 113,794,153 (GRCm39) S118Y probably damaging Het
Boc A T 16: 44,340,836 (GRCm39) M38K probably benign Het
Ccdc171 A T 4: 83,599,481 (GRCm39) E773D possibly damaging Het
Clxn A G 16: 14,742,001 (GRCm39) M212V probably benign Het
Dmtn C T 14: 70,850,098 (GRCm39) probably benign Het
Dnah10 G A 5: 124,832,887 (GRCm39) probably benign Het
Fam83b T C 9: 76,410,358 (GRCm39) N184S probably benign Het
Fam98c A G 7: 28,852,265 (GRCm39) M98T probably damaging Het
Fbn1 T C 2: 125,143,529 (GRCm39) K2867E probably benign Het
Fsip2 A T 2: 82,820,107 (GRCm39) E5280V possibly damaging Het
Fuom T C 7: 139,679,631 (GRCm39) probably benign Het
Gm3476 A T 14: 6,118,512 (GRCm38) S204T probably benign Het
Grhl3 A G 4: 135,288,617 (GRCm39) F23L probably benign Het
Il4i1 G T 7: 44,489,213 (GRCm39) R334L probably damaging Het
Ipo13 A G 4: 117,758,228 (GRCm39) S712P probably damaging Het
Lama4 G T 10: 38,932,843 (GRCm39) S573I probably damaging Het
Lrp11 A G 10: 7,480,058 (GRCm39) H371R probably benign Het
Mkln1 T A 6: 31,466,303 (GRCm39) I520N probably damaging Het
Nagpa G T 16: 5,016,480 (GRCm39) C236* probably null Het
Nktr A G 9: 121,556,436 (GRCm39) N38S probably damaging Het
Nlrp10 G A 7: 108,525,088 (GRCm39) R131C probably benign Het
Nxpe2 T C 9: 48,231,211 (GRCm39) D386G possibly damaging Het
Prpf39 T A 12: 65,100,740 (GRCm39) probably benign Het
Retreg2 A G 1: 75,121,755 (GRCm39) probably benign Het
S100a4 G T 3: 90,513,084 (GRCm39) S60I possibly damaging Het
Slc12a3 G T 8: 95,059,905 (GRCm39) G184C probably damaging Het
Slc25a46 C T 18: 31,742,807 (GRCm39) D20N possibly damaging Het
Smc3 A G 19: 53,622,509 (GRCm39) K695E probably benign Het
Speer2 A T 16: 69,653,955 (GRCm39) probably null Het
Taar4 T G 10: 23,836,936 (GRCm39) V182G possibly damaging Het
Ttll1 C G 15: 83,386,326 (GRCm39) S93T probably benign Het
Ubl3 A T 5: 148,443,008 (GRCm39) probably null Het
Vmn2r72 T C 7: 85,398,396 (GRCm39) E528G probably benign Het
Zfp52 A C 17: 21,780,311 (GRCm39) E53A probably damaging Het
Other mutations in Vmn2r16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01116:Vmn2r16 APN 5 109,488,294 (GRCm39) missense probably damaging 1.00
IGL01374:Vmn2r16 APN 5 109,478,283 (GRCm39) missense probably benign 0.00
IGL01391:Vmn2r16 APN 5 109,511,627 (GRCm39) missense possibly damaging 0.50
IGL01419:Vmn2r16 APN 5 109,510,267 (GRCm39) splice site probably benign
IGL01634:Vmn2r16 APN 5 109,488,177 (GRCm39) missense probably benign 0.00
IGL01845:Vmn2r16 APN 5 109,511,762 (GRCm39) missense probably damaging 1.00
IGL01875:Vmn2r16 APN 5 109,478,277 (GRCm39) missense probably benign 0.01
IGL01910:Vmn2r16 APN 5 109,487,951 (GRCm39) missense probably damaging 1.00
IGL02217:Vmn2r16 APN 5 109,487,676 (GRCm39) missense probably damaging 0.98
IGL02327:Vmn2r16 APN 5 109,487,987 (GRCm39) missense probably benign 0.01
IGL02491:Vmn2r16 APN 5 109,487,703 (GRCm39) nonsense probably null
IGL02531:Vmn2r16 APN 5 109,488,134 (GRCm39) missense probably damaging 0.99
IGL02680:Vmn2r16 APN 5 109,487,948 (GRCm39) missense probably benign 0.44
IGL02884:Vmn2r16 APN 5 109,508,757 (GRCm39) missense possibly damaging 0.94
IGL03084:Vmn2r16 APN 5 109,478,292 (GRCm39) missense probably damaging 0.99
IGL03096:Vmn2r16 APN 5 109,487,751 (GRCm39) missense probably damaging 0.99
IGL03355:Vmn2r16 APN 5 109,511,580 (GRCm39) missense possibly damaging 0.74
R0280:Vmn2r16 UTSW 5 109,488,005 (GRCm39) missense possibly damaging 0.88
R0594:Vmn2r16 UTSW 5 109,511,762 (GRCm39) missense probably damaging 1.00
R1016:Vmn2r16 UTSW 5 109,487,754 (GRCm39) missense probably damaging 1.00
R1109:Vmn2r16 UTSW 5 109,487,652 (GRCm39) missense probably damaging 0.98
R1626:Vmn2r16 UTSW 5 109,511,443 (GRCm39) missense probably damaging 1.00
R1909:Vmn2r16 UTSW 5 109,511,853 (GRCm39) missense probably benign 0.01
R1929:Vmn2r16 UTSW 5 109,487,124 (GRCm39) missense possibly damaging 0.92
R1982:Vmn2r16 UTSW 5 109,511,890 (GRCm39) missense probably benign 0.01
R3038:Vmn2r16 UTSW 5 109,487,199 (GRCm39) missense probably damaging 1.00
R3437:Vmn2r16 UTSW 5 109,478,362 (GRCm39) missense probably damaging 0.99
R3734:Vmn2r16 UTSW 5 109,478,280 (GRCm39) missense probably benign 0.11
R3820:Vmn2r16 UTSW 5 109,510,143 (GRCm39) missense probably benign 0.36
R3873:Vmn2r16 UTSW 5 109,488,177 (GRCm39) missense probably benign 0.33
R4165:Vmn2r16 UTSW 5 109,478,427 (GRCm39) missense possibly damaging 0.80
R4373:Vmn2r16 UTSW 5 109,511,667 (GRCm39) missense probably damaging 1.00
R4575:Vmn2r16 UTSW 5 109,511,665 (GRCm39) missense possibly damaging 0.81
R4576:Vmn2r16 UTSW 5 109,511,665 (GRCm39) missense possibly damaging 0.81
R4578:Vmn2r16 UTSW 5 109,511,665 (GRCm39) missense possibly damaging 0.81
R4637:Vmn2r16 UTSW 5 109,478,280 (GRCm39) missense probably benign 0.00
R4696:Vmn2r16 UTSW 5 109,487,168 (GRCm39) missense probably benign 0.01
R5026:Vmn2r16 UTSW 5 109,508,722 (GRCm39) nonsense probably null
R5180:Vmn2r16 UTSW 5 109,478,391 (GRCm39) missense probably benign 0.01
R5433:Vmn2r16 UTSW 5 109,511,708 (GRCm39) missense probably damaging 1.00
R5955:Vmn2r16 UTSW 5 109,511,613 (GRCm39) missense possibly damaging 0.78
R5958:Vmn2r16 UTSW 5 109,510,153 (GRCm39) missense possibly damaging 0.81
R6353:Vmn2r16 UTSW 5 109,488,119 (GRCm39) missense probably benign 0.33
R6389:Vmn2r16 UTSW 5 109,478,344 (GRCm39) missense probably benign 0.19
R6819:Vmn2r16 UTSW 5 109,488,412 (GRCm39) missense probably benign 0.04
R6994:Vmn2r16 UTSW 5 109,487,969 (GRCm39) missense probably damaging 1.00
R7061:Vmn2r16 UTSW 5 109,511,620 (GRCm39) missense probably damaging 0.99
R7063:Vmn2r16 UTSW 5 109,511,650 (GRCm39) missense probably damaging 1.00
R7220:Vmn2r16 UTSW 5 109,508,772 (GRCm39) missense probably damaging 0.97
R7268:Vmn2r16 UTSW 5 109,488,331 (GRCm39) nonsense probably null
R7420:Vmn2r16 UTSW 5 109,511,736 (GRCm39) missense probably damaging 0.96
R7591:Vmn2r16 UTSW 5 109,510,223 (GRCm39) missense probably damaging 0.99
R7644:Vmn2r16 UTSW 5 109,487,837 (GRCm39) missense probably damaging 1.00
R7939:Vmn2r16 UTSW 5 109,487,705 (GRCm39) missense possibly damaging 0.79
R7977:Vmn2r16 UTSW 5 109,488,015 (GRCm39) missense probably damaging 1.00
R7987:Vmn2r16 UTSW 5 109,488,015 (GRCm39) missense probably damaging 1.00
R8023:Vmn2r16 UTSW 5 109,488,272 (GRCm39) nonsense probably null
R8427:Vmn2r16 UTSW 5 109,488,138 (GRCm39) missense probably benign 0.03
R8436:Vmn2r16 UTSW 5 109,511,649 (GRCm39) missense probably damaging 1.00
R8475:Vmn2r16 UTSW 5 109,487,073 (GRCm39) missense probably benign 0.01
R8554:Vmn2r16 UTSW 5 109,511,997 (GRCm39) missense probably benign 0.13
R8771:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8774:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8774-TAIL:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8775:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8775-TAIL:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8777:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8777-TAIL:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8825:Vmn2r16 UTSW 5 109,487,019 (GRCm39) missense probably benign 0.41
R8865:Vmn2r16 UTSW 5 109,487,910 (GRCm39) missense probably benign 0.33
R8900:Vmn2r16 UTSW 5 109,511,619 (GRCm39) missense probably benign 0.04
R9365:Vmn2r16 UTSW 5 109,488,064 (GRCm39) missense probably damaging 0.99
R9683:Vmn2r16 UTSW 5 109,511,677 (GRCm39) missense probably damaging 1.00
X0027:Vmn2r16 UTSW 5 109,487,175 (GRCm39) missense probably damaging 1.00
Z1088:Vmn2r16 UTSW 5 109,511,779 (GRCm39) frame shift probably null
Z1088:Vmn2r16 UTSW 5 109,488,381 (GRCm39) missense probably benign 0.03
Z1177:Vmn2r16 UTSW 5 109,487,864 (GRCm39) missense possibly damaging 0.79
Predicted Primers PCR Primer
(F):5'- CATGAATGACCCAACATCACTCTCTGT -3'
(R):5'- AAAGCTCCTCCTGTAGCCCACT -3'

Sequencing Primer
(F):5'- AATATATCTGTCTTTCCTGGAAGCC -3'
(R):5'- AGCCCACTCCATGTTTTCAGATATAC -3'
Posted On 2014-01-29