Incidental Mutation 'R1226:Zfp866'
ID 152234
Institutional Source Beutler Lab
Gene Symbol Zfp866
Ensembl Gene ENSMUSG00000043090
Gene Name zinc finger protein 866
Synonyms 9830167H18Rik, D330038O06Rik
MMRRC Submission 039295-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R1226 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 70213974-70227561 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 70218940 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 227 (F227L)
Ref Sequence ENSEMBL: ENSMUSP00000119781 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000131784] [ENSMUST00000137573] [ENSMUST00000149782]
AlphaFold Q6PGD2
Predicted Effect probably benign
Transcript: ENSMUST00000126915
SMART Domains Protein: ENSMUSP00000122850
Gene: ENSMUSG00000092544

DomainStartEndE-ValueType
KRAB 16 73 1.96e-17 SMART
PDB:2I13|B 104 210 3e-6 PDB
SCOP:d1fgja_ 114 216 2e-6 SMART
Blast:KRAB 189 209 3e-6 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000131784
SMART Domains Protein: ENSMUSP00000116972
Gene: ENSMUSG00000043090

DomainStartEndE-ValueType
Blast:KRAB 1 35 2e-19 BLAST
Predicted Effect probably damaging
Transcript: ENSMUST00000137573
AA Change: F227L

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000119781
Gene: ENSMUSG00000043090
AA Change: F227L

DomainStartEndE-ValueType
KRAB 4 67 4.26e-18 SMART
ZnF_C2H2 162 184 6.42e-4 SMART
ZnF_C2H2 190 212 3.69e-4 SMART
ZnF_C2H2 218 240 3.89e-3 SMART
ZnF_C2H2 246 268 3.34e-2 SMART
ZnF_C2H2 274 296 1.76e-1 SMART
ZnF_C2H2 302 324 5.42e-2 SMART
ZnF_C2H2 330 352 1.38e-3 SMART
ZnF_C2H2 358 380 6.78e-3 SMART
ZnF_C2H2 386 408 2.09e-3 SMART
ZnF_C2H2 414 436 9.44e-2 SMART
ZnF_C2H2 442 464 2.95e-3 SMART
ZnF_C2H2 470 492 9.73e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000149782
SMART Domains Protein: ENSMUSP00000123252
Gene: ENSMUSG00000092544

DomainStartEndE-ValueType
KRAB 80 139 1.2e-17 SMART
ZnF_C2H2 155 177 1.69e-3 SMART
ZnF_C2H2 182 204 8.47e-4 SMART
ZnF_C2H2 210 232 7.15e-2 SMART
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.4%
  • 10x: 96.3%
  • 20x: 92.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb10 C T 8: 124,688,791 (GRCm39) G495D probably damaging Het
Abcd2 G T 15: 91,075,246 (GRCm39) A189E probably benign Het
Ahcy T C 2: 154,906,817 (GRCm39) T159A probably benign Het
Arfgef2 T C 2: 166,669,560 (GRCm39) V84A probably damaging Het
Brwd1 G A 16: 95,832,748 (GRCm39) T1036M probably benign Het
Ccdc187 G T 2: 26,166,133 (GRCm39) S765R probably damaging Het
Cfap210 A G 2: 69,617,553 (GRCm39) M76T possibly damaging Het
Chd1l G A 3: 97,469,941 (GRCm39) R862* probably null Het
Crmp1 A G 5: 37,430,778 (GRCm39) D71G probably damaging Het
Ctif CTGTGTCCGGTGT CTGT 18: 75,654,650 (GRCm39) probably benign Het
Ctsb A C 14: 63,379,189 (GRCm39) Y267S probably damaging Het
Cyp4a12b T A 4: 115,290,164 (GRCm39) I239N possibly damaging Het
Dna2 T C 10: 62,796,203 (GRCm39) V544A possibly damaging Het
Dnhd1 T A 7: 105,346,106 (GRCm39) F2364Y probably damaging Het
Fsip2 A T 2: 82,811,355 (GRCm39) E2558V probably damaging Het
Gm10061 A C 16: 88,948,169 (GRCm39) Y48S unknown Het
Herc1 T A 9: 66,323,545 (GRCm39) M1353K probably benign Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Lin7a T C 10: 107,107,780 (GRCm39) V20A probably benign Het
Lsr T A 7: 30,671,308 (GRCm39) I142F probably damaging Het
Mei1 C T 15: 81,964,285 (GRCm39) T275I possibly damaging Het
Mon2 A G 10: 122,838,724 (GRCm39) V1593A probably benign Het
Mrpl32 A G 13: 14,786,096 (GRCm39) I74T probably benign Het
Nek11 C T 9: 105,270,091 (GRCm39) V44I probably damaging Het
Noa1 A G 5: 77,455,402 (GRCm39) V438A possibly damaging Het
Or5an1c A C 19: 12,218,950 (GRCm39) I25R probably benign Het
Or7g16 C T 9: 18,727,266 (GRCm39) C108Y probably benign Het
Or8g18 G C 9: 39,149,547 (GRCm39) P58A probably benign Het
Pcdhb17 T C 18: 37,620,313 (GRCm39) L701P probably damaging Het
Pde11a G A 2: 75,988,698 (GRCm39) S481L probably benign Het
Prkdc T C 16: 15,491,861 (GRCm39) I602T possibly damaging Het
Ptprh T A 7: 4,606,091 (GRCm39) R3* probably null Het
Reln A G 5: 22,115,864 (GRCm39) L3048P probably damaging Het
Slc6a11 T A 6: 114,171,624 (GRCm39) I265N possibly damaging Het
Sorbs2 T C 8: 46,248,656 (GRCm39) S636P probably damaging Het
Supt5 T C 7: 28,028,172 (GRCm39) I44V probably benign Het
Tdrd6 T A 17: 43,937,523 (GRCm39) E1175V possibly damaging Het
Tnxb A C 17: 34,907,903 (GRCm39) T1316P probably damaging Het
Ufc1 A C 1: 171,116,810 (GRCm39) D119E probably benign Het
Vmn1r220 A G 13: 23,368,294 (GRCm39) F134S probably damaging Het
Zfp106 A G 2: 120,354,560 (GRCm39) S1404P probably damaging Het
Zfyve28 A T 5: 34,374,408 (GRCm39) H535Q probably benign Het
Other mutations in Zfp866
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02755:Zfp866 APN 8 70,219,290 (GRCm39) critical splice donor site probably null
R0238:Zfp866 UTSW 8 70,219,365 (GRCm39) missense probably damaging 1.00
R1073:Zfp866 UTSW 8 70,220,272 (GRCm39) splice site probably benign
R1388:Zfp866 UTSW 8 70,218,834 (GRCm39) missense probably benign 0.16
R5129:Zfp866 UTSW 8 70,220,359 (GRCm39) splice site probably null
R5204:Zfp866 UTSW 8 70,218,690 (GRCm39) missense probably damaging 0.96
R5225:Zfp866 UTSW 8 70,218,091 (GRCm39) missense possibly damaging 0.93
R5504:Zfp866 UTSW 8 70,218,341 (GRCm39) missense probably benign 0.07
R5912:Zfp866 UTSW 8 70,218,934 (GRCm39) missense probably benign 0.03
R6046:Zfp866 UTSW 8 70,218,373 (GRCm39) missense probably damaging 1.00
R6939:Zfp866 UTSW 8 70,218,871 (GRCm39) missense probably damaging 0.99
R7033:Zfp866 UTSW 8 70,218,491 (GRCm39) missense probably damaging 1.00
R7111:Zfp866 UTSW 8 70,219,221 (GRCm39) missense probably benign 0.05
R7351:Zfp866 UTSW 8 70,218,547 (GRCm39) missense probably damaging 1.00
R7458:Zfp866 UTSW 8 70,218,202 (GRCm39) nonsense probably null
R8098:Zfp866 UTSW 8 70,218,628 (GRCm39) missense probably benign 0.02
R8755:Zfp866 UTSW 8 70,219,381 (GRCm39) missense possibly damaging 0.78
R9575:Zfp866 UTSW 8 70,219,288 (GRCm39) missense probably damaging 0.98
Predicted Primers
Posted On 2014-01-29