Incidental Mutation 'R1226:Or7g16'
ID 152236
Institutional Source Beutler Lab
Gene Symbol Or7g16
Ensembl Gene ENSMUSG00000078116
Gene Name olfactory receptor family 7 subfamily G member 16
Synonyms GA_x6K02T2PVTD-12559294-12558356, Olfr828, MOR149-1
MMRRC Submission 039295-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.136) question?
Stock # R1226 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 18726650-18727588 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 18727266 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 108 (C108Y)
Ref Sequence ENSEMBL: ENSMUSP00000148853 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000104914] [ENSMUST00000213018] [ENSMUST00000215380]
AlphaFold Q8VFM8
Predicted Effect probably benign
Transcript: ENSMUST00000104914
AA Change: C108Y

PolyPhen 2 Score 0.342 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000100514
Gene: ENSMUSG00000078116
AA Change: C108Y

DomainStartEndE-ValueType
Pfam:7tm_4 31 310 1e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 305 1.4e-5 PFAM
Pfam:7tm_1 41 290 2.1e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213018
AA Change: C108Y
Predicted Effect probably benign
Transcript: ENSMUST00000215380
AA Change: C108Y

PolyPhen 2 Score 0.342 (Sensitivity: 0.90; Specificity: 0.89)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.4%
  • 10x: 96.3%
  • 20x: 92.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb10 C T 8: 124,688,791 (GRCm39) G495D probably damaging Het
Abcd2 G T 15: 91,075,246 (GRCm39) A189E probably benign Het
Ahcy T C 2: 154,906,817 (GRCm39) T159A probably benign Het
Arfgef2 T C 2: 166,669,560 (GRCm39) V84A probably damaging Het
Brwd1 G A 16: 95,832,748 (GRCm39) T1036M probably benign Het
Ccdc187 G T 2: 26,166,133 (GRCm39) S765R probably damaging Het
Cfap210 A G 2: 69,617,553 (GRCm39) M76T possibly damaging Het
Chd1l G A 3: 97,469,941 (GRCm39) R862* probably null Het
Crmp1 A G 5: 37,430,778 (GRCm39) D71G probably damaging Het
Ctif CTGTGTCCGGTGT CTGT 18: 75,654,650 (GRCm39) probably benign Het
Ctsb A C 14: 63,379,189 (GRCm39) Y267S probably damaging Het
Cyp4a12b T A 4: 115,290,164 (GRCm39) I239N possibly damaging Het
Dna2 T C 10: 62,796,203 (GRCm39) V544A possibly damaging Het
Dnhd1 T A 7: 105,346,106 (GRCm39) F2364Y probably damaging Het
Fsip2 A T 2: 82,811,355 (GRCm39) E2558V probably damaging Het
Gm10061 A C 16: 88,948,169 (GRCm39) Y48S unknown Het
Herc1 T A 9: 66,323,545 (GRCm39) M1353K probably benign Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Lin7a T C 10: 107,107,780 (GRCm39) V20A probably benign Het
Lsr T A 7: 30,671,308 (GRCm39) I142F probably damaging Het
Mei1 C T 15: 81,964,285 (GRCm39) T275I possibly damaging Het
Mon2 A G 10: 122,838,724 (GRCm39) V1593A probably benign Het
Mrpl32 A G 13: 14,786,096 (GRCm39) I74T probably benign Het
Nek11 C T 9: 105,270,091 (GRCm39) V44I probably damaging Het
Noa1 A G 5: 77,455,402 (GRCm39) V438A possibly damaging Het
Or5an1c A C 19: 12,218,950 (GRCm39) I25R probably benign Het
Or8g18 G C 9: 39,149,547 (GRCm39) P58A probably benign Het
Pcdhb17 T C 18: 37,620,313 (GRCm39) L701P probably damaging Het
Pde11a G A 2: 75,988,698 (GRCm39) S481L probably benign Het
Prkdc T C 16: 15,491,861 (GRCm39) I602T possibly damaging Het
Ptprh T A 7: 4,606,091 (GRCm39) R3* probably null Het
Reln A G 5: 22,115,864 (GRCm39) L3048P probably damaging Het
Slc6a11 T A 6: 114,171,624 (GRCm39) I265N possibly damaging Het
Sorbs2 T C 8: 46,248,656 (GRCm39) S636P probably damaging Het
Supt5 T C 7: 28,028,172 (GRCm39) I44V probably benign Het
Tdrd6 T A 17: 43,937,523 (GRCm39) E1175V possibly damaging Het
Tnxb A C 17: 34,907,903 (GRCm39) T1316P probably damaging Het
Ufc1 A C 1: 171,116,810 (GRCm39) D119E probably benign Het
Vmn1r220 A G 13: 23,368,294 (GRCm39) F134S probably damaging Het
Zfp106 A G 2: 120,354,560 (GRCm39) S1404P probably damaging Het
Zfp866 A G 8: 70,218,940 (GRCm39) F227L probably damaging Het
Zfyve28 A T 5: 34,374,408 (GRCm39) H535Q probably benign Het
Other mutations in Or7g16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02088:Or7g16 APN 9 18,727,219 (GRCm39) missense probably benign 0.03
IGL02103:Or7g16 APN 9 18,727,005 (GRCm39) missense probably damaging 1.00
IGL02792:Or7g16 APN 9 18,727,254 (GRCm39) missense probably benign 0.00
IGL02964:Or7g16 APN 9 18,727,024 (GRCm39) missense probably damaging 1.00
IGL03087:Or7g16 APN 9 18,727,380 (GRCm39) missense probably damaging 1.00
IGL03105:Or7g16 APN 9 18,726,685 (GRCm39) missense probably benign 0.03
R0330:Or7g16 UTSW 9 18,726,937 (GRCm39) missense probably damaging 1.00
R0335:Or7g16 UTSW 9 18,727,290 (GRCm39) missense probably damaging 1.00
R0862:Or7g16 UTSW 9 18,727,002 (GRCm39) missense probably damaging 0.98
R2004:Or7g16 UTSW 9 18,726,801 (GRCm39) missense probably benign 0.05
R2005:Or7g16 UTSW 9 18,726,801 (GRCm39) missense probably benign 0.05
R2006:Or7g16 UTSW 9 18,726,801 (GRCm39) missense probably benign 0.05
R2199:Or7g16 UTSW 9 18,727,219 (GRCm39) missense probably damaging 0.97
R2230:Or7g16 UTSW 9 18,727,021 (GRCm39) missense probably damaging 1.00
R2399:Or7g16 UTSW 9 18,727,323 (GRCm39) missense probably benign 0.07
R5652:Or7g16 UTSW 9 18,726,922 (GRCm39) missense probably damaging 1.00
R5738:Or7g16 UTSW 9 18,727,125 (GRCm39) missense possibly damaging 0.81
R6416:Or7g16 UTSW 9 18,727,188 (GRCm39) missense probably benign 0.21
R6813:Or7g16 UTSW 9 18,727,188 (GRCm39) missense probably benign 0.21
R7092:Or7g16 UTSW 9 18,727,353 (GRCm39) missense probably damaging 1.00
R7109:Or7g16 UTSW 9 18,726,904 (GRCm39) missense probably benign 0.01
R7292:Or7g16 UTSW 9 18,727,486 (GRCm39) missense probably damaging 1.00
R7429:Or7g16 UTSW 9 18,726,650 (GRCm39) makesense probably null
R7430:Or7g16 UTSW 9 18,726,650 (GRCm39) makesense probably null
R7490:Or7g16 UTSW 9 18,727,229 (GRCm39) nonsense probably null
R7835:Or7g16 UTSW 9 18,727,105 (GRCm39) missense probably benign 0.05
R8016:Or7g16 UTSW 9 18,727,588 (GRCm39) start codon destroyed probably null 0.56
R8809:Or7g16 UTSW 9 18,726,919 (GRCm39) missense probably damaging 0.99
R8859:Or7g16 UTSW 9 18,726,992 (GRCm39) missense possibly damaging 0.90
R9036:Or7g16 UTSW 9 18,727,569 (GRCm39) missense probably damaging 1.00
R9079:Or7g16 UTSW 9 18,726,731 (GRCm39) missense probably damaging 0.99
R9177:Or7g16 UTSW 9 18,726,742 (GRCm39) missense probably damaging 1.00
R9182:Or7g16 UTSW 9 18,726,742 (GRCm39) missense probably damaging 1.00
R9184:Or7g16 UTSW 9 18,727,138 (GRCm39) missense probably benign 0.10
RF003:Or7g16 UTSW 9 18,726,778 (GRCm39) missense probably benign 0.03
X0026:Or7g16 UTSW 9 18,727,059 (GRCm39) missense possibly damaging 0.95
Z1176:Or7g16 UTSW 9 18,727,276 (GRCm39) frame shift probably null
Z1177:Or7g16 UTSW 9 18,727,444 (GRCm39) missense probably benign 0.09
Predicted Primers PCR Primer
(F):5'- TGTGCAGAAGGACAACCGCAAC -3'
(R):5'- ACAGATGATATAGCACTGAAGCCCCTC -3'

Sequencing Primer
(F):5'- CGCAACACCATCAGTCCAAG -3'
(R):5'- GATCACCATCTTGGGAAATCTGC -3'
Posted On 2014-01-29