Incidental Mutation 'R1226:Vmn1r220'
ID 152246
Institutional Source Beutler Lab
Gene Symbol Vmn1r220
Ensembl Gene ENSMUSG00000096099
Gene Name vomeronasal 1 receptor 220
Synonyms V1rh12
MMRRC Submission 039295-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.122) question?
Stock # R1226 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 23367798-23368694 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 23368294 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 134 (F134S)
Ref Sequence ENSEMBL: ENSMUSP00000154302 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072385] [ENSMUST00000226651] [ENSMUST00000227679] [ENSMUST00000227950] [ENSMUST00000228239] [ENSMUST00000228854]
AlphaFold Q8R272
Predicted Effect probably damaging
Transcript: ENSMUST00000072385
AA Change: F134S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000072222
Gene: ENSMUSG00000096099
AA Change: F134S

DomainStartEndE-ValueType
Pfam:V1R 33 297 5e-38 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226651
AA Change: F134S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000227679
AA Change: F134S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000227950
AA Change: F134S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000228239
AA Change: F134S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000228854
AA Change: F134S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.4%
  • 10x: 96.3%
  • 20x: 92.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb10 C T 8: 124,688,791 (GRCm39) G495D probably damaging Het
Abcd2 G T 15: 91,075,246 (GRCm39) A189E probably benign Het
Ahcy T C 2: 154,906,817 (GRCm39) T159A probably benign Het
Arfgef2 T C 2: 166,669,560 (GRCm39) V84A probably damaging Het
Brwd1 G A 16: 95,832,748 (GRCm39) T1036M probably benign Het
Ccdc187 G T 2: 26,166,133 (GRCm39) S765R probably damaging Het
Cfap210 A G 2: 69,617,553 (GRCm39) M76T possibly damaging Het
Chd1l G A 3: 97,469,941 (GRCm39) R862* probably null Het
Crmp1 A G 5: 37,430,778 (GRCm39) D71G probably damaging Het
Ctif CTGTGTCCGGTGT CTGT 18: 75,654,650 (GRCm39) probably benign Het
Ctsb A C 14: 63,379,189 (GRCm39) Y267S probably damaging Het
Cyp4a12b T A 4: 115,290,164 (GRCm39) I239N possibly damaging Het
Dna2 T C 10: 62,796,203 (GRCm39) V544A possibly damaging Het
Dnhd1 T A 7: 105,346,106 (GRCm39) F2364Y probably damaging Het
Fsip2 A T 2: 82,811,355 (GRCm39) E2558V probably damaging Het
Gm10061 A C 16: 88,948,169 (GRCm39) Y48S unknown Het
Herc1 T A 9: 66,323,545 (GRCm39) M1353K probably benign Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Lin7a T C 10: 107,107,780 (GRCm39) V20A probably benign Het
Lsr T A 7: 30,671,308 (GRCm39) I142F probably damaging Het
Mei1 C T 15: 81,964,285 (GRCm39) T275I possibly damaging Het
Mon2 A G 10: 122,838,724 (GRCm39) V1593A probably benign Het
Mrpl32 A G 13: 14,786,096 (GRCm39) I74T probably benign Het
Nek11 C T 9: 105,270,091 (GRCm39) V44I probably damaging Het
Noa1 A G 5: 77,455,402 (GRCm39) V438A possibly damaging Het
Or5an1c A C 19: 12,218,950 (GRCm39) I25R probably benign Het
Or7g16 C T 9: 18,727,266 (GRCm39) C108Y probably benign Het
Or8g18 G C 9: 39,149,547 (GRCm39) P58A probably benign Het
Pcdhb17 T C 18: 37,620,313 (GRCm39) L701P probably damaging Het
Pde11a G A 2: 75,988,698 (GRCm39) S481L probably benign Het
Prkdc T C 16: 15,491,861 (GRCm39) I602T possibly damaging Het
Ptprh T A 7: 4,606,091 (GRCm39) R3* probably null Het
Reln A G 5: 22,115,864 (GRCm39) L3048P probably damaging Het
Slc6a11 T A 6: 114,171,624 (GRCm39) I265N possibly damaging Het
Sorbs2 T C 8: 46,248,656 (GRCm39) S636P probably damaging Het
Supt5 T C 7: 28,028,172 (GRCm39) I44V probably benign Het
Tdrd6 T A 17: 43,937,523 (GRCm39) E1175V possibly damaging Het
Tnxb A C 17: 34,907,903 (GRCm39) T1316P probably damaging Het
Ufc1 A C 1: 171,116,810 (GRCm39) D119E probably benign Het
Zfp106 A G 2: 120,354,560 (GRCm39) S1404P probably damaging Het
Zfp866 A G 8: 70,218,940 (GRCm39) F227L probably damaging Het
Zfyve28 A T 5: 34,374,408 (GRCm39) H535Q probably benign Het
Other mutations in Vmn1r220
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00870:Vmn1r220 APN 13 23,368,647 (GRCm39) missense probably null 0.01
IGL00953:Vmn1r220 APN 13 23,367,935 (GRCm39) missense probably benign 0.00
IGL00972:Vmn1r220 APN 13 23,368,558 (GRCm39) missense probably damaging 1.00
IGL01511:Vmn1r220 APN 13 23,368,384 (GRCm39) missense probably damaging 1.00
IGL02967:Vmn1r220 APN 13 23,368,162 (GRCm39) missense probably damaging 0.97
IGL03040:Vmn1r220 APN 13 23,367,952 (GRCm39) missense possibly damaging 0.92
R1869:Vmn1r220 UTSW 13 23,368,457 (GRCm39) missense probably damaging 1.00
R2312:Vmn1r220 UTSW 13 23,368,147 (GRCm39) missense probably damaging 1.00
R4223:Vmn1r220 UTSW 13 23,368,148 (GRCm39) missense probably benign 0.22
R5655:Vmn1r220 UTSW 13 23,368,298 (GRCm39) missense probably benign 0.03
R6188:Vmn1r220 UTSW 13 23,368,084 (GRCm39) missense probably damaging 1.00
R6276:Vmn1r220 UTSW 13 23,368,465 (GRCm39) missense probably damaging 1.00
R7756:Vmn1r220 UTSW 13 23,367,877 (GRCm39) missense probably benign 0.25
R8275:Vmn1r220 UTSW 13 23,368,483 (GRCm39) nonsense probably null
R8867:Vmn1r220 UTSW 13 23,368,271 (GRCm39) missense probably benign 0.22
R8981:Vmn1r220 UTSW 13 23,368,423 (GRCm39) missense probably damaging 1.00
R9218:Vmn1r220 UTSW 13 23,368,609 (GRCm39) missense probably benign 0.10
R9278:Vmn1r220 UTSW 13 23,368,258 (GRCm39) missense possibly damaging 0.79
Predicted Primers PCR Primer
(F):5'- TGGCACCCTGAAACACTGCATC -3'
(R):5'- AGCTTCTGGGACCTCATCTGCAAC -3'

Sequencing Primer
(F):5'- TGAAACACTGCATCTCTCAGG -3'
(R):5'- GAGAAACTTCCTAGATGACATTGGC -3'
Posted On 2014-01-29