Incidental Mutation 'R1226:Or5an1c'
ID 152258
Institutional Source Beutler Lab
Gene Symbol Or5an1c
Ensembl Gene ENSMUSG00000067519
Gene Name olfactory receptor family 5 subfamily AN member 1C
Synonyms MOR214-1, Olfr262, GA_x6K02T2N4A9-18144-19082, MOR214-9
MMRRC Submission 039295-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R1226 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 12218085-12219023 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 12218950 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Arginine at position 25 (I25R)
Ref Sequence ENSEMBL: ENSMUSP00000085120 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087818]
AlphaFold Q8VFV8
Predicted Effect probably benign
Transcript: ENSMUST00000087818
AA Change: I25R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000085120
Gene: ENSMUSG00000067519
AA Change: I25R

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 2.3e-55 PFAM
Pfam:7tm_1 42 291 1.2e-20 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.4%
  • 10x: 96.3%
  • 20x: 92.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb10 C T 8: 124,688,791 (GRCm39) G495D probably damaging Het
Abcd2 G T 15: 91,075,246 (GRCm39) A189E probably benign Het
Ahcy T C 2: 154,906,817 (GRCm39) T159A probably benign Het
Arfgef2 T C 2: 166,669,560 (GRCm39) V84A probably damaging Het
Brwd1 G A 16: 95,832,748 (GRCm39) T1036M probably benign Het
Ccdc187 G T 2: 26,166,133 (GRCm39) S765R probably damaging Het
Cfap210 A G 2: 69,617,553 (GRCm39) M76T possibly damaging Het
Chd1l G A 3: 97,469,941 (GRCm39) R862* probably null Het
Crmp1 A G 5: 37,430,778 (GRCm39) D71G probably damaging Het
Ctif CTGTGTCCGGTGT CTGT 18: 75,654,650 (GRCm39) probably benign Het
Ctsb A C 14: 63,379,189 (GRCm39) Y267S probably damaging Het
Cyp4a12b T A 4: 115,290,164 (GRCm39) I239N possibly damaging Het
Dna2 T C 10: 62,796,203 (GRCm39) V544A possibly damaging Het
Dnhd1 T A 7: 105,346,106 (GRCm39) F2364Y probably damaging Het
Fsip2 A T 2: 82,811,355 (GRCm39) E2558V probably damaging Het
Gm10061 A C 16: 88,948,169 (GRCm39) Y48S unknown Het
Herc1 T A 9: 66,323,545 (GRCm39) M1353K probably benign Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Lin7a T C 10: 107,107,780 (GRCm39) V20A probably benign Het
Lsr T A 7: 30,671,308 (GRCm39) I142F probably damaging Het
Mei1 C T 15: 81,964,285 (GRCm39) T275I possibly damaging Het
Mon2 A G 10: 122,838,724 (GRCm39) V1593A probably benign Het
Mrpl32 A G 13: 14,786,096 (GRCm39) I74T probably benign Het
Nek11 C T 9: 105,270,091 (GRCm39) V44I probably damaging Het
Noa1 A G 5: 77,455,402 (GRCm39) V438A possibly damaging Het
Or7g16 C T 9: 18,727,266 (GRCm39) C108Y probably benign Het
Or8g18 G C 9: 39,149,547 (GRCm39) P58A probably benign Het
Pcdhb17 T C 18: 37,620,313 (GRCm39) L701P probably damaging Het
Pde11a G A 2: 75,988,698 (GRCm39) S481L probably benign Het
Prkdc T C 16: 15,491,861 (GRCm39) I602T possibly damaging Het
Ptprh T A 7: 4,606,091 (GRCm39) R3* probably null Het
Reln A G 5: 22,115,864 (GRCm39) L3048P probably damaging Het
Slc6a11 T A 6: 114,171,624 (GRCm39) I265N possibly damaging Het
Sorbs2 T C 8: 46,248,656 (GRCm39) S636P probably damaging Het
Supt5 T C 7: 28,028,172 (GRCm39) I44V probably benign Het
Tdrd6 T A 17: 43,937,523 (GRCm39) E1175V possibly damaging Het
Tnxb A C 17: 34,907,903 (GRCm39) T1316P probably damaging Het
Ufc1 A C 1: 171,116,810 (GRCm39) D119E probably benign Het
Vmn1r220 A G 13: 23,368,294 (GRCm39) F134S probably damaging Het
Zfp106 A G 2: 120,354,560 (GRCm39) S1404P probably damaging Het
Zfp866 A G 8: 70,218,940 (GRCm39) F227L probably damaging Het
Zfyve28 A T 5: 34,374,408 (GRCm39) H535Q probably benign Het
Other mutations in Or5an1c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01432:Or5an1c APN 19 12,218,891 (GRCm39) missense probably damaging 0.99
IGL02170:Or5an1c APN 19 12,218,120 (GRCm39) missense probably benign
IGL02748:Or5an1c APN 19 12,218,204 (GRCm39) missense probably benign 0.01
IGL02896:Or5an1c APN 19 12,218,353 (GRCm39) nonsense probably null
R0365:Or5an1c UTSW 19 12,218,440 (GRCm39) missense probably benign 0.13
R0374:Or5an1c UTSW 19 12,218,505 (GRCm39) missense probably damaging 1.00
R1319:Or5an1c UTSW 19 12,218,866 (GRCm39) missense probably damaging 1.00
R1426:Or5an1c UTSW 19 12,218,546 (GRCm39) missense possibly damaging 0.81
R1453:Or5an1c UTSW 19 12,218,956 (GRCm39) missense probably benign
R1675:Or5an1c UTSW 19 12,218,195 (GRCm39) missense probably benign 0.37
R1773:Or5an1c UTSW 19 12,219,023 (GRCm39) start codon destroyed probably null 0.03
R1778:Or5an1c UTSW 19 12,218,819 (GRCm39) missense probably benign
R1820:Or5an1c UTSW 19 12,218,612 (GRCm39) missense probably damaging 1.00
R3161:Or5an1c UTSW 19 12,218,860 (GRCm39) missense probably benign 0.06
R3412:Or5an1c UTSW 19 12,218,954 (GRCm39) missense probably benign 0.00
R4387:Or5an1c UTSW 19 12,218,503 (GRCm39) missense probably damaging 0.98
R4389:Or5an1c UTSW 19 12,218,503 (GRCm39) missense probably damaging 0.98
R4782:Or5an1c UTSW 19 12,218,936 (GRCm39) missense probably benign 0.01
R4885:Or5an1c UTSW 19 12,218,082 (GRCm39) splice site probably null
R4915:Or5an1c UTSW 19 12,218,737 (GRCm39) missense probably benign 0.31
R5254:Or5an1c UTSW 19 12,218,612 (GRCm39) missense probably damaging 1.00
R5726:Or5an1c UTSW 19 12,218,644 (GRCm39) missense probably damaging 0.99
R6579:Or5an1c UTSW 19 12,218,726 (GRCm39) missense probably benign
R7062:Or5an1c UTSW 19 12,218,089 (GRCm39) missense probably benign
R7424:Or5an1c UTSW 19 12,218,318 (GRCm39) missense possibly damaging 0.65
R9491:Or5an1c UTSW 19 12,218,606 (GRCm39) missense probably benign 0.01
R9736:Or5an1c UTSW 19 12,218,920 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- TGGCTGCCATGAGACAAGACTCAC -3'
(R):5'- TTCAGCGGTCCTAGAAGAAGGACA -3'

Sequencing Primer
(F):5'- GCCCACAAAACTGTTAGTTTGC -3'
(R):5'- GGACATATGGTGTGAAAATTGTAATG -3'
Posted On 2014-01-29