Incidental Mutation 'R1231:Psg16'
ID 152291
Institutional Source Beutler Lab
Gene Symbol Psg16
Ensembl Gene ENSMUSG00000066760
Gene Name pregnancy specific glycoprotein 16
Synonyms bCEA, Cea11
MMRRC Submission 039300-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1231 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 17074040-17133450 bp(+) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 17095305 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 271 (Y271*)
Ref Sequence ENSEMBL: ENSMUSP00000113025 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071399] [ENSMUST00000118367] [ENSMUST00000152671]
AlphaFold Q8K0U8
Predicted Effect probably null
Transcript: ENSMUST00000071399
AA Change: Y271*
SMART Domains Protein: ENSMUSP00000071348
Gene: ENSMUSG00000066760
AA Change: Y271*

DomainStartEndE-ValueType
IG_like 6 52 1.42e2 SMART
IG 71 172 1.21e-2 SMART
IG 191 292 2.56e-1 SMART
IG_like 302 395 5.13e0 SMART
Predicted Effect probably null
Transcript: ENSMUST00000118367
AA Change: Y271*
SMART Domains Protein: ENSMUSP00000113025
Gene: ENSMUSG00000066760
AA Change: Y271*

DomainStartEndE-ValueType
IG_like 6 52 1.42e2 SMART
IG 71 172 1.21e-2 SMART
IG 191 292 2.56e-1 SMART
IGc2 308 372 3.56e-9 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131153
Predicted Effect probably benign
Transcript: ENSMUST00000152671
SMART Domains Protein: ENSMUSP00000118977
Gene: ENSMUSG00000066760

DomainStartEndE-ValueType
low complexity region 24 40 N/A INTRINSIC
IG 46 143 4.29e-3 SMART
IG 162 261 2.94e-1 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.3%
  • 10x: 96.0%
  • 20x: 91.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 21 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ascc3 C T 10: 50,823,660 P1860S probably damaging Het
Cabp5 T C 7: 13,405,425 I125T probably damaging Het
Ccnd2 A T 6: 127,130,400 S269T probably benign Het
Cmss1 C T 16: 57,316,197 R104H probably benign Het
Dock9 A T 14: 121,575,950 M1522K possibly damaging Het
Fcrl5 A G 3: 87,442,179 H87R probably benign Het
Gabrr3 G A 16: 59,461,400 D373N probably benign Het
Gm21738 T A 14: 19,415,957 Y194F probably benign Het
Gm21738 T C 14: 19,415,963 K192R probably benign Het
Gtf3c3 C T 1: 54,417,778 A488T probably damaging Het
Itgae C T 11: 73,119,379 T565I probably benign Het
Mocos G T 18: 24,679,701 A551S probably benign Het
Mtmr9 A T 14: 63,528,191 N418K possibly damaging Het
Mtus2 T A 5: 148,077,388 S330R probably benign Het
Olfr31 A T 14: 14,328,515 M135L probably benign Het
Psmd2 T A 16: 20,655,585 M297K possibly damaging Het
Rnf220 A T 4: 117,489,884 S110R probably damaging Het
Sned1 G A 1: 93,281,654 V830M possibly damaging Het
St8sia5 T C 18: 77,232,806 Y49H probably damaging Het
Umodl1 A G 17: 30,959,278 Y76C probably damaging Het
Urm1 G T 2: 29,832,699 A15S probably damaging Het
Other mutations in Psg16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01993:Psg16 APN 7 17093706 missense probably benign 0.08
IGL02258:Psg16 APN 7 17095292 missense probably damaging 1.00
R0379:Psg16 UTSW 7 17130658 missense probably benign 0.09
R0389:Psg16 UTSW 7 17095163 missense probably benign
R0443:Psg16 UTSW 7 17095163 missense probably benign
R1594:Psg16 UTSW 7 17093823 missense probably damaging 1.00
R2064:Psg16 UTSW 7 17093748 missense possibly damaging 0.91
R2118:Psg16 UTSW 7 17090623 missense probably benign 0.33
R3806:Psg16 UTSW 7 17090684 missense probably benign 0.24
R4397:Psg16 UTSW 7 17090698 missense possibly damaging 0.68
R4583:Psg16 UTSW 7 17095172 missense probably benign 0.01
R4685:Psg16 UTSW 7 17090534 missense probably benign 0.00
R4929:Psg16 UTSW 7 17095106 missense possibly damaging 0.79
R5310:Psg16 UTSW 7 17090635 missense probably damaging 0.99
R6106:Psg16 UTSW 7 17095166 missense possibly damaging 0.73
R6320:Psg16 UTSW 7 17088187 missense probably damaging 1.00
R6702:Psg16 UTSW 7 17090396 missense probably damaging 1.00
R6703:Psg16 UTSW 7 17090396 missense probably damaging 1.00
R7329:Psg16 UTSW 7 17090686 missense possibly damaging 0.86
R7679:Psg16 UTSW 7 17093760 missense probably damaging 1.00
R8292:Psg16 UTSW 7 17093776 missense probably damaging 0.99
R8372:Psg16 UTSW 7 17095315 missense probably benign 0.10
R8491:Psg16 UTSW 7 17090512 missense probably damaging 1.00
R8796:Psg16 UTSW 7 17093889 missense possibly damaging 0.90
R9131:Psg16 UTSW 7 17098099 missense probably benign 0.00
R9437:Psg16 UTSW 7 17093790 missense probably damaging 1.00
R9659:Psg16 UTSW 7 17090599 missense possibly damaging 0.55
R9746:Psg16 UTSW 7 17098161 missense probably benign 0.02
R9788:Psg16 UTSW 7 17090599 missense possibly damaging 0.55
Predicted Primers PCR Primer
(F):5'- ATGCAGGTCACCGTCTTTCCAC -3'
(R):5'- ATGCTGTTGGTTCATCCCAGGTATG -3'

Sequencing Primer
(F):5'- TCGATCCAATGCCACGGTATG -3'
(R):5'- TGCCCAAACCCTAAGGTGAG -3'
Posted On 2014-01-29