Mutagenetix > Incidental Mutation

Incidental Mutation 'R1237:Vmn1r212'

152471

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r212

Ensembl Gene

ENSMUSG00000071490

Gene Name

vomeronasal 1 receptor 212

Synonyms

V1rh18

MMRRC Submission

039304-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.075) question?

Stock #

R1237 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

23067212-23068375 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 23067638 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 232 (Q232*)

Ref Sequence

ENSEMBL: ENSMUSP00000093655 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095960]

AlphaFold

Q8R268

Predicted Effect

probably null
Transcript: ENSMUST00000095960
AA Change: Q232*

SMART Domains

Protein: ENSMUSP00000093655
Gene: ENSMUSG00000071490
AA Change: Q232*

Domain	Start	End	E-Value	Type
Pfam:TAS2R	2	292	1.2e-7	PFAM
Pfam:V1R	34	297	5.4e-36	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000158990

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000226672

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000226881

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.0%
3x: 98.2%
10x: 95.9%
20x: 91.8%

Validation Efficiency

98% (40/41)

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg3	T	C	5: 105,096,223 (GRCm39)	T500A	probably damaging	Het
Amz1	A	T	5: 140,727,039 (GRCm39)	M1L	probably damaging	Het
Angptl1	T	A	1: 156,686,154 (GRCm39)	N413K	probably damaging	Het
Ankrd13b	T	C	11: 77,365,400 (GRCm39)	T70A	probably damaging	Het
Cacna1c	C	T	6: 118,589,586 (GRCm39)	R1446H	probably damaging	Het
Ccdc174	C	T	6: 91,867,768 (GRCm39)		probably benign	Het
Ccnc	T	A	4: 21,730,457 (GRCm39)	F31L	probably benign	Het
Celsr1	A	C	15: 85,788,175 (GRCm39)	S2692R	probably benign	Het
Chd1l	C	T	3: 97,490,047 (GRCm39)	E503K	probably benign	Het
Ddhd1	A	T	14: 45,839,107 (GRCm39)	D65E	probably benign	Het
Dync1h1	A	G	12: 110,632,393 (GRCm39)	N4504S	probably benign	Het
Enthd1	A	G	15: 80,418,799 (GRCm39)	S167P	probably damaging	Het
Fat1	A	T	8: 45,497,316 (GRCm39)	Y4267F	probably damaging	Het
Hectd4	C	T	5: 121,459,570 (GRCm39)	A813V	possibly damaging	Het
Ibtk	T	C	9: 85,602,801 (GRCm39)	S735G	probably benign	Het
Itga4	A	G	2: 79,109,490 (GRCm39)	I230V	probably null	Het
Kcnh8	A	T	17: 53,200,988 (GRCm39)	Q474L	probably damaging	Het
Kcnh8	G	T	17: 53,200,989 (GRCm39)	Q474H	probably damaging	Het
Mib1	C	T	18: 10,768,149 (GRCm39)	T466I	probably damaging	Het
Or12d12	T	A	17: 37,611,156 (GRCm39)	R52S	probably benign	Het
Or2ad1	C	T	13: 21,326,337 (GRCm39)	V297I	probably benign	Het
Or2l5	A	C	16: 19,334,375 (GRCm39)	Y4D	probably benign	Het
Parp14	G	A	16: 35,677,130 (GRCm39)	A946V	probably benign	Het
Prdx6b	A	G	2: 80,123,520 (GRCm39)	I110V	probably benign	Het
Prf1	A	C	10: 61,139,428 (GRCm39)	D462A	probably benign	Het
Rps6ka5	T	C	12: 100,541,964 (GRCm39)	D391G	possibly damaging	Het
Scn7a	A	T	2: 66,510,639 (GRCm39)	N1254K	probably damaging	Het
Skor2	A	T	18: 76,963,827 (GRCm39)	K924*	probably null	Het
Slc22a21	A	G	11: 53,870,598 (GRCm39)	I29T	probably benign	Het
Tas2r140	T	C	6: 133,032,171 (GRCm39)	T196A	probably benign	Het
Thrap3	A	G	4: 126,073,862 (GRCm39)	S295P	probably benign	Het
Trim43a	GATTTATTTATTTATTTATTTATTTATTTATTTATTTATT	GATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATT	9: 88,465,042 (GRCm39)		probably benign	Het
Ubtd2	C	T	11: 32,466,125 (GRCm39)	R115W	probably damaging	Het
Unc93b1	A	G	19: 3,985,228 (GRCm39)	E12G	possibly damaging	Het
Vgll3	T	A	16: 65,636,459 (GRCm39)	Y203*	probably null	Het
Vmn2r107	T	A	17: 20,576,947 (GRCm39)	L315*	probably null	Het
Vmn2r84	T	A	10: 130,223,725 (GRCm39)		probably null	Het
Washc5	A	G	15: 59,210,757 (GRCm39)		probably benign	Het

Other mutations in Vmn1r212

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01131:Vmn1r212	APN	13	23,067,329 (GRCm39)	missense	unknown
IGL01678:Vmn1r212	APN	13	23,068,081 (GRCm39)	missense	probably damaging	1.00
R0798:Vmn1r212	UTSW	13	23,067,868 (GRCm39)	missense	probably damaging	1.00
R1331:Vmn1r212	UTSW	13	23,067,562 (GRCm39)	missense	probably benign	0.33
R2064:Vmn1r212	UTSW	13	23,068,285 (GRCm39)	missense	probably benign	0.28
R2356:Vmn1r212	UTSW	13	23,068,120 (GRCm39)	nonsense	probably null
R2846:Vmn1r212	UTSW	13	23,068,262 (GRCm39)	missense	probably damaging	0.99
R3896:Vmn1r212	UTSW	13	23,068,067 (GRCm39)	missense	probably benign	0.00
R3937:Vmn1r212	UTSW	13	23,067,358 (GRCm39)	missense	unknown
R4722:Vmn1r212	UTSW	13	23,068,078 (GRCm39)	missense	probably damaging	1.00
R5233:Vmn1r212	UTSW	13	23,067,304 (GRCm39)	missense	unknown
R6043:Vmn1r212	UTSW	13	23,068,258 (GRCm39)	missense	probably damaging	0.98
R7199:Vmn1r212	UTSW	13	23,067,731 (GRCm39)	missense	probably benign	0.12
R7413:Vmn1r212	UTSW	13	23,067,718 (GRCm39)	missense	probably damaging	1.00
R7840:Vmn1r212	UTSW	13	23,067,323 (GRCm39)	missense	unknown
R8054:Vmn1r212	UTSW	13	23,067,935 (GRCm39)	missense	probably benign	0.25
R8844:Vmn1r212	UTSW	13	23,067,526 (GRCm39)	missense	probably benign	0.00
R8929:Vmn1r212	UTSW	13	23,067,494 (GRCm39)	missense	possibly damaging	0.69
R9538:Vmn1r212	UTSW	13	23,067,451 (GRCm39)	missense	probably benign	0.03
R9612:Vmn1r212	UTSW	13	23,067,443 (GRCm39)	missense	possibly damaging	0.96
Z1088:Vmn1r212	UTSW	13	23,067,932 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GAACTCCATCCCTGTGAATCAGCAC -3'
(R):5'- AGGCCAAAGTCTGTATGGCACATC -3'

Sequencing Primer
(F):5'- CTGTGAATCAGCACCAGGG -3'
(R):5'- CTGAATGTATCACAGCTTAGGAGTG -3'

Posted On

2014-01-29