Mutagenetix > Incidental Mutations

Incidental Mutation 'R1237:Olfr167'

152476

Institutional Source

Beutler Lab

Gene Symbol

Olfr167

Ensembl Gene

ENSMUSG00000045341

Gene Name

olfactory receptor 167

Synonyms

MOR272-1, GA_x54KRFPKG5P-15963726-15962788

MMRRC Submission

039304-MU

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.335) question?

Stock #

R1237 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

19509558-19522266 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 19515625 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Aspartic acid at position 4 (Y4D)

Ref Sequence

ENSEMBL: ENSMUSP00000150102 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000054606] [ENSMUST00000214315]

AlphaFold

Q8VGJ5

Predicted Effect

probably benign
Transcript: ENSMUST00000054606
AA Change: Y4D

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000055344
Gene: ENSMUSG00000045341
AA Change: Y4D

Domain	Start	End	E-Value	Type
Pfam:7tm_4	30	306	4.8e-46	PFAM
Pfam:7TM_GPCR_Srsx	33	295	1.2e-6	PFAM
Pfam:7tm_1	40	289	1.8e-26	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214315
AA Change: Y4D

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000217566

Meta Mutation Damage Score

0.1362

Coding Region Coverage

1x: 99.0%
3x: 98.2%
10x: 95.9%
20x: 91.8%

Validation Efficiency

98% (40/41)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg3	T	C	5: 104,948,357	T500A	probably damaging	Het
Amz1	A	T	5: 140,741,284	M1L	probably damaging	Het
Angptl1	T	A	1: 156,858,584	N413K	probably damaging	Het
Ankrd13b	T	C	11: 77,474,574	T70A	probably damaging	Het
Cacna1c	C	T	6: 118,612,625	R1446H	probably damaging	Het
Ccdc174	C	T	6: 91,890,787		probably benign	Het
Ccnc	T	A	4: 21,730,457	F31L	probably benign	Het
Celsr1	A	C	15: 85,903,974	S2692R	probably benign	Het
Chd1l	C	T	3: 97,582,731	E503K	probably benign	Het
Ddhd1	A	T	14: 45,601,650	D65E	probably benign	Het
Dync1h1	A	G	12: 110,665,959	N4504S	probably benign	Het
Enthd1	A	G	15: 80,534,598	S167P	probably damaging	Het
Fat1	A	T	8: 45,044,279	Y4267F	probably damaging	Het
Hectd4	C	T	5: 121,321,507	A813V	possibly damaging	Het
Ibtk	T	C	9: 85,720,748	S735G	probably benign	Het
Itga4	A	G	2: 79,279,146	I230V	probably null	Het
Kcnh8	A	T	17: 52,893,960	Q474L	probably damaging	Het
Kcnh8	G	T	17: 52,893,961	Q474H	probably damaging	Het
Mib1	C	T	18: 10,768,149	T466I	probably damaging	Het
Olfr101	T	A	17: 37,300,265	R52S	probably benign	Het
Olfr1368	C	T	13: 21,142,167	V297I	probably benign	Het
Parp14	G	A	16: 35,856,760	A946V	probably benign	Het
Prdx6b	A	G	2: 80,293,176	I110V	probably benign	Het
Prf1	A	C	10: 61,303,649	D462A	probably benign	Het
Rps6ka5	T	C	12: 100,575,705	D391G	possibly damaging	Het
Scn7a	A	T	2: 66,680,295	N1254K	probably damaging	Het
Skor2	A	T	18: 76,876,132	K924*	probably null	Het
Slc22a21	A	G	11: 53,979,772	I29T	probably benign	Het
Tas2r140	T	C	6: 133,055,208	T196A	probably benign	Het
Thrap3	A	G	4: 126,180,069	S295P	probably benign	Het
Trim43a	GATTTATTTATTTATTTATTTATTTATTTATTTATTTATT	GATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATT	9: 88,582,989		probably benign	Het
Ubtd2	C	T	11: 32,516,125	R115W	probably damaging	Het
Unc93b1	A	G	19: 3,935,228	E12G	possibly damaging	Het
Vgll3	T	A	16: 65,839,573	Y203*	probably null	Het
Vmn1r212	G	A	13: 22,883,468	Q232*	probably null	Het
Vmn2r107	T	A	17: 20,356,685	L315*	probably null	Het
Vmn2r84	T	A	10: 130,387,856		probably null	Het
Washc5	A	G	15: 59,338,908		probably benign	Het

Other mutations in Olfr167

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01535:Olfr167	APN	16	19515478	missense	probably benign	0.01
IGL02115:Olfr167	APN	16	19515103	missense	probably damaging	1.00
IGL02562:Olfr167	APN	16	19514964	missense	possibly damaging	0.74
BB008:Olfr167	UTSW	16	19515508	missense	possibly damaging	0.94
BB018:Olfr167	UTSW	16	19515508	missense	possibly damaging	0.94
R0366:Olfr167	UTSW	16	19514848	missense	probably benign	0.13
R0673:Olfr167	UTSW	16	19515396	missense	probably damaging	1.00
R1187:Olfr167	UTSW	16	19515046	missense	probably benign	0.01
R1975:Olfr167	UTSW	16	19514836	missense	probably damaging	0.99
R1977:Olfr167	UTSW	16	19514836	missense	probably damaging	0.99
R1997:Olfr167	UTSW	16	19515042	missense	probably damaging	1.00
R2225:Olfr167	UTSW	16	19515246	missense	probably benign	0.05
R2226:Olfr167	UTSW	16	19515246	missense	probably benign	0.05
R4078:Olfr167	UTSW	16	19515232	missense	possibly damaging	0.76
R5019:Olfr167	UTSW	16	19515535	missense	probably damaging	0.99
R5071:Olfr167	UTSW	16	19515027	missense	probably benign	0.00
R5278:Olfr167	UTSW	16	19515378	nonsense	probably null
R5415:Olfr167	UTSW	16	19515246	missense	possibly damaging	0.94
R5744:Olfr167	UTSW	16	19515336	missense	probably benign	0.00
R5991:Olfr167	UTSW	16	19514757	missense	probably damaging	0.99
R6151:Olfr167	UTSW	16	19515531	missense	probably damaging	1.00
R6540:Olfr167	UTSW	16	19514821	missense	probably benign
R7014:Olfr167	UTSW	16	19515456	missense	probably benign	0.20
R7145:Olfr167	UTSW	16	19514899	missense	probably damaging	0.99
R7535:Olfr167	UTSW	16	19514794	missense	probably damaging	1.00
R7677:Olfr167	UTSW	16	19514928	missense	probably benign	0.42
R7715:Olfr167	UTSW	16	19514730	missense	probably benign	0.00
R7931:Olfr167	UTSW	16	19515508	missense	possibly damaging	0.94
R8137:Olfr167	UTSW	16	19515096	missense	possibly damaging	0.89
R8671:Olfr167	UTSW	16	19515054	missense	possibly damaging	0.63

Predicted Primers

PCR Primer
(F):5'- TGAAATCCACACCCAATGAAGGAGATG -3'
(R):5'- GTTCCAAACATGCAGTATGAAGTCGC -3'

Sequencing Primer
(F):5'- ACCATTTTAGGGACAATGGTAGAG -3'
(R):5'- ATGCAGTATGAAGTCGCATGTTC -3'

Posted On

2014-01-29