Mutagenetix > Incidental Mutations

Incidental Mutation 'V7581:Clasp1'

152531

Institutional Source

Beutler Lab

Gene Symbol

Clasp1

Ensembl Gene

ENSMUSG00000064302

Gene Name

CLIP associating protein 1

Synonyms

1700030C23Rik, B130045P17Rik, CLASP1, mCLASP1, 5730583A19Rik, CLASP1alpha

Accession Numbers

Is this an essential gene?

Probably essential (E-score: 0.954) question?

Stock #

V7581 () of strain stinger

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

118389058-118612678 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 118581348 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glutamine at position 1027 (R1027Q)

Ref Sequence

ENSEMBL: ENSMUSP00000142203 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049404] [ENSMUST00000070989] [ENSMUST00000165223] [ENSMUST00000178710] [ENSMUST00000185405] [ENSMUST00000186349] [ENSMUST00000187713] [ENSMUST00000188710] [ENSMUST00000189262] [ENSMUST00000189570] [ENSMUST00000189738] [ENSMUST00000191445] [ENSMUST00000190571] [ENSMUST00000191823] [ENSMUST00000204325] [ENSMUST00000190733]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000049404
AA Change: R1319Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000042266
Gene: ENSMUSG00000064302
AA Change: R1319Q

Domain	Start	End	E-Value	Type
TOG	1	232	7.31e-51	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	1.14e-11	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	674	707	N/A	INTRINSIC
low complexity region	751	763	N/A	INTRINSIC
low complexity region	821	831	N/A	INTRINSIC
TOG	847	1085	3.23e-1	SMART
low complexity region	1096	1113	N/A	INTRINSIC
low complexity region	1134	1147	N/A	INTRINSIC
low complexity region	1225	1236	N/A	INTRINSIC
TOG	1287	1525	4.96e-30	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000070989
AA Change: R1309Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000067858
Gene: ENSMUSG00000064302
AA Change: R1309Q

Domain	Start	End	E-Value	Type
TOG	1	232	7.31e-51	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	1.14e-11	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	674	707	N/A	INTRINSIC
low complexity region	751	763	N/A	INTRINSIC
low complexity region	850	860	N/A	INTRINSIC
TOG	876	1114	3.23e-1	SMART
low complexity region	1125	1142	N/A	INTRINSIC
low complexity region	1215	1226	N/A	INTRINSIC
TOG	1277	1515	4.96e-30	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000165223
AA Change: R1235Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000128089
Gene: ENSMUSG00000064302
AA Change: R1235Q

Domain	Start	End	E-Value	Type
TOG	1	232	7.31e-51	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	1.14e-11	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	684	714	N/A	INTRINSIC
low complexity region	792	802	N/A	INTRINSIC
TOG	818	1056	3.23e-1	SMART
low complexity region	1067	1084	N/A	INTRINSIC
low complexity region	1157	1168	N/A	INTRINSIC
TOG	1219	1457	4.96e-30	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000178710
AA Change: R1242Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000137137
Gene: ENSMUSG00000064302
AA Change: R1242Q

Domain	Start	End	E-Value	Type
TOG	1	232	7.31e-51	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	1.14e-11	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	668	698	N/A	INTRINSIC
low complexity region	752	766	N/A	INTRINSIC
low complexity region	784	794	N/A	INTRINSIC
TOG	810	1047	6.55e-2	SMART
low complexity region	1058	1075	N/A	INTRINSIC
low complexity region	1148	1159	N/A	INTRINSIC
TOG	1210	1448	4.96e-30	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000185405
AA Change: R1275Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000139619
Gene: ENSMUSG00000064302
AA Change: R1275Q

Domain	Start	End	E-Value	Type
TOG	1	232	3.4e-55	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	5.5e-16	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	682	715	N/A	INTRINSIC
low complexity region	769	783	N/A	INTRINSIC
low complexity region	801	811	N/A	INTRINSIC
TOG	827	1065	1.6e-5	SMART
low complexity region	1076	1093	N/A	INTRINSIC
low complexity region	1166	1177	N/A	INTRINSIC
TOG	1228	1466	2.3e-34	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000186349
AA Change: R1319Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000141105
Gene: ENSMUSG00000064302
AA Change: R1319Q

Domain	Start	End	E-Value	Type
TOG	1	232	7.31e-51	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	1.14e-11	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	674	707	N/A	INTRINSIC
low complexity region	751	763	N/A	INTRINSIC
low complexity region	821	831	N/A	INTRINSIC
TOG	847	1085	3.23e-1	SMART
low complexity region	1096	1113	N/A	INTRINSIC
low complexity region	1134	1147	N/A	INTRINSIC
low complexity region	1225	1236	N/A	INTRINSIC
TOG	1287	1525	4.96e-30	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000187713
AA Change: R1258Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000139526
Gene: ENSMUSG00000064302
AA Change: R1258Q

Domain	Start	End	E-Value	Type
TOG	1	232	3.4e-55	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	5.5e-16	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	684	714	N/A	INTRINSIC
low complexity region	768	782	N/A	INTRINSIC
low complexity region	800	810	N/A	INTRINSIC
TOG	826	1064	1.6e-5	SMART
low complexity region	1075	1092	N/A	INTRINSIC
low complexity region	1165	1176	N/A	INTRINSIC
TOG	1227	1465	2.3e-34	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000188710
AA Change: R1309Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000140593
Gene: ENSMUSG00000064302
AA Change: R1309Q

Domain	Start	End	E-Value	Type
TOG	1	232	3.4e-55	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	5.5e-16	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	674	707	N/A	INTRINSIC
low complexity region	751	763	N/A	INTRINSIC
low complexity region	818	832	N/A	INTRINSIC
low complexity region	850	860	N/A	INTRINSIC
TOG	876	1114	1.6e-5	SMART
low complexity region	1125	1142	N/A	INTRINSIC
low complexity region	1215	1226	N/A	INTRINSIC
TOG	1277	1515	2.3e-34	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000189262
AA Change: R1243Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000140860
Gene: ENSMUSG00000064302
AA Change: R1243Q

Domain	Start	End	E-Value	Type
TOG	1	232	3.4e-55	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	5.5e-16	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	668	698	N/A	INTRINSIC
low complexity region	776	786	N/A	INTRINSIC
TOG	802	1040	1.6e-5	SMART
low complexity region	1051	1068	N/A	INTRINSIC
low complexity region	1141	1152	N/A	INTRINSIC
TOG	1203	1441	2.3e-34	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000189570
AA Change: R1251Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000140167
Gene: ENSMUSG00000064302
AA Change: R1251Q

Domain	Start	End	E-Value	Type
TOG	1	232	3.4e-55	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	5.5e-16	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	684	714	N/A	INTRINSIC
low complexity region	792	802	N/A	INTRINSIC
TOG	818	1055	3.2e-6	SMART
low complexity region	1066	1083	N/A	INTRINSIC
low complexity region	1156	1167	N/A	INTRINSIC
TOG	1218	1456	2.3e-34	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000189738
AA Change: R1260Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000140665
Gene: ENSMUSG00000064302
AA Change: R1260Q

Domain	Start	End	E-Value	Type
TOG	1	232	7.31e-51	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	1.14e-11	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	668	698	N/A	INTRINSIC
low complexity region	752	766	N/A	INTRINSIC
low complexity region	784	794	N/A	INTRINSIC
TOG	810	1048	3.23e-1	SMART
low complexity region	1059	1076	N/A	INTRINSIC
low complexity region	1149	1160	N/A	INTRINSIC
TOG	1211	1449	4.96e-30	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000191445
AA Change: R1252Q

PolyPhen 2 Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000140095
Gene: ENSMUSG00000064302
AA Change: R1252Q

Domain	Start	End	E-Value	Type
TOG	1	232	3.4e-55	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	5.5e-16	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	674	707	N/A	INTRINSIC
low complexity region	761	775	N/A	INTRINSIC
low complexity region	793	803	N/A	INTRINSIC
TOG	819	1056	3.2e-6	SMART
low complexity region	1067	1084	N/A	INTRINSIC
low complexity region	1157	1168	N/A	INTRINSIC
TOG	1219	1457	2.3e-34	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000190571
AA Change: R1335Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000140019
Gene: ENSMUSG00000064302
AA Change: R1335Q

Domain	Start	End	E-Value	Type
TOG	1	232	3.4e-55	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	5.5e-16	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	682	715	N/A	INTRINSIC
low complexity region	759	771	N/A	INTRINSIC
low complexity region	805	819	N/A	INTRINSIC
low complexity region	837	847	N/A	INTRINSIC
TOG	863	1101	1.6e-5	SMART
low complexity region	1112	1129	N/A	INTRINSIC
low complexity region	1150	1163	N/A	INTRINSIC
low complexity region	1241	1252	N/A	INTRINSIC
TOG	1303	1541	2.3e-34	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000191823
AA Change: R1027Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000142203
Gene: ENSMUSG00000064302
AA Change: R1027Q

Domain	Start	End	E-Value	Type
low complexity region	20	34	N/A	INTRINSIC
low complexity region	48	64	N/A	INTRINSIC
TOG	87	319	5.6e-16	SMART
low complexity region	347	362	N/A	INTRINSIC
low complexity region	374	401	N/A	INTRINSIC
low complexity region	450	483	N/A	INTRINSIC
low complexity region	537	551	N/A	INTRINSIC
low complexity region	568	578	N/A	INTRINSIC
TOG	594	832	1.6e-5	SMART
low complexity region	843	860	N/A	INTRINSIC
low complexity region	933	944	N/A	INTRINSIC
TOG	995	1233	2.4e-34	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000203646

Predicted Effect

probably benign
Transcript: ENSMUST00000204325

Predicted Effect

probably benign
Transcript: ENSMUST00000190733

Predicted Effect

probably benign
Transcript: ENSMUST00000192387

Meta Mutation Damage Score

0.1437

Coding Region Coverage

1x: 99.0%
3x: 98.2%
10x: 95.7%
20x: 90.5%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9530002B09Rik	A	T	4: 122,701,257	H102L	possibly damaging	Het
Abcb10	GGCCATCG	GG	8: 123,969,761		probably benign	Het
Atp6v1h	A	G	1: 5,124,443	T282A	possibly damaging	Het
D630003M21Rik	T	C	2: 158,201,011	T870A	probably benign	Het
Dnah12	T	A	14: 26,773,093	N1369K	possibly damaging	Het
Dnajc22	T	A	15: 99,101,482	Y183N	probably damaging	Het
Dpyd	C	T	3: 118,897,126	Q295*	probably null	Het
Erv3	T	C	2: 131,855,926	H171R	possibly damaging	Het
Fam221b	T	C	4: 43,665,865	T249A	probably benign	Het
Fcgr1	T	C	3: 96,284,276	*405W	probably null	Het
Glrx3	A	G	7: 137,459,153	H172R	probably benign	Het
Gm10770	T	A	2: 150,179,484	K38*	probably null	Het
Gm4787	G	A	12: 81,377,567	Q606*	probably null	Het
Hira	G	A	16: 18,894,821	A29T	probably damaging	Het
Hnrnpab	A	T	11: 51,602,624	N252K	probably benign	Het
Izumo4	A	T	10: 80,703,891	T155S	probably benign	Het
Kcnb2	A	G	1: 15,710,091	I396V	probably benign	Het
Klc1	A	T	12: 111,774,572	I161F	probably benign	Het
Lpar5	C	A	6: 125,081,727	A137E	possibly damaging	Het
Lrp4	C	T	2: 91,488,518	S900L	possibly damaging	Het
Muc6	T	G	7: 141,647,613	E808A	probably benign	Het
Olfr1406	G	T	1: 173,183,964	L157I	probably benign	Het
Olfr480	G	T	7: 108,066,678	T40K	probably benign	Het
Otop3	T	A	11: 115,344,838	L432Q	probably damaging	Het
Papln	C	T	12: 83,778,834	R608C	possibly damaging	Het
Pelp1	T	A	11: 70,398,150	T257S	probably damaging	Het
Pik3cd	A	C	4: 149,657,319	L390R	probably damaging	Het
Ppwd1	A	G	13: 104,220,237	Y257H	probably damaging	Het
Prkcb	G	T	7: 122,528,476	W274C	probably damaging	Het
Rbbp8nl	T	A	2: 180,278,208	T558S	probably benign	Het
Recql4	T	C	15: 76,706,169	D705G	possibly damaging	Het
Slc30a4	T	A	2: 122,689,538	M136L	probably benign	Het
Slc5a6	C	T	5: 31,042,613		probably null	Het
Spaca1	T	C	4: 34,039,311	E192G	probably damaging	Het
Spata31	C	A	13: 64,921,648	P537T	probably benign	Het
Tmc3	T	C	7: 83,622,505	V955A	probably benign	Het
Tnrc6c	G	A	11: 117,723,326	R770H	probably damaging	Het
Toe1	A	T	4: 116,806,111	N56K	probably damaging	Het
Tprkb	A	G	6: 85,928,782	K150E	probably damaging	Het
Trps1	T	C	15: 50,831,577	K150E	probably damaging	Het
Tspyl3	A	G	2: 153,225,060	V86A	probably benign	Het
Vmn2r68	C	T	7: 85,221,880	V732I	probably benign	Het
Wdr60	A	C	12: 116,211,840	S906A	possibly damaging	Het
Zfp292	C	T	4: 34,806,783	C2087Y	possibly damaging	Het
Zfp933	G	A	4: 147,826,470	A223V	probably damaging	Het
Zmynd8	G	A	2: 165,812,394	R724*	probably null	Het

Other mutations in Clasp1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01785:Clasp1	APN	1	118497736	missense	possibly damaging	0.74
IGL01786:Clasp1	APN	1	118497736	missense	possibly damaging	0.74
IGL01871:Clasp1	APN	1	118570889	missense	probably damaging	1.00
IGL02066:Clasp1	APN	1	118565260	critical splice donor site	probably null
IGL02602:Clasp1	APN	1	118471785	missense	probably damaging	0.99
IGL02683:Clasp1	APN	1	118539266	missense	probably benign	0.33
IGL02728:Clasp1	APN	1	118602377	missense	probably damaging	1.00
IGL02820:Clasp1	APN	1	118551104	missense	possibly damaging	0.77
IGL02874:Clasp1	APN	1	118552043	missense	possibly damaging	0.86
IGL02975:Clasp1	APN	1	118462547	missense	probably damaging	1.00
IGL03100:Clasp1	APN	1	118467896	missense	possibly damaging	0.79
IGL03115:Clasp1	APN	1	118501323	nonsense	probably null
IGL03122:Clasp1	APN	1	118510277	missense	probably damaging	1.00
IGL03180:Clasp1	APN	1	118505525	missense	probably benign	0.33
IGL03248:Clasp1	APN	1	118602476	missense	probably benign	0.01
IGL03388:Clasp1	APN	1	118505503	missense	possibly damaging	0.95
F5770:Clasp1	UTSW	1	118581348	missense	probably damaging	1.00
I2288:Clasp1	UTSW	1	118565229	missense	probably benign	0.09
PIT4585001:Clasp1	UTSW	1	118462555	missense	probably damaging	0.99
R0079:Clasp1	UTSW	1	118543304	missense	probably damaging	1.00
R0395:Clasp1	UTSW	1	118539331	missense	possibly damaging	0.48
R0960:Clasp1	UTSW	1	118552026	missense	probably benign	0.39
R1448:Clasp1	UTSW	1	118508916	missense	probably benign	0.01
R1497:Clasp1	UTSW	1	118552058	missense	probably benign	0.42
R1607:Clasp1	UTSW	1	118504959	missense	probably damaging	0.98
R1722:Clasp1	UTSW	1	118590464	missense	probably damaging	1.00
R1758:Clasp1	UTSW	1	118548025	missense	probably damaging	1.00
R1765:Clasp1	UTSW	1	118505531	missense	probably damaging	0.99
R1855:Clasp1	UTSW	1	118508894	missense	probably damaging	1.00
R1861:Clasp1	UTSW	1	118570931	missense	possibly damaging	0.93
R1874:Clasp1	UTSW	1	118600585	critical splice donor site	probably null
R1942:Clasp1	UTSW	1	118501348	missense	possibly damaging	0.94
R2025:Clasp1	UTSW	1	118504899	missense	probably damaging	1.00
R2174:Clasp1	UTSW	1	118560095	missense	probably damaging	1.00
R2280:Clasp1	UTSW	1	118565183	missense	probably benign	0.05
R2288:Clasp1	UTSW	1	118578878	missense	probably benign
R2895:Clasp1	UTSW	1	118459838	missense	probably damaging	1.00
R3958:Clasp1	UTSW	1	118467881	missense	probably damaging	0.99
R4073:Clasp1	UTSW	1	118503848	missense	probably damaging	1.00
R4206:Clasp1	UTSW	1	118578906	missense	probably damaging	1.00
R4465:Clasp1	UTSW	1	118561078	missense	probably damaging	1.00
R4609:Clasp1	UTSW	1	118503035	intron	probably benign
R4679:Clasp1	UTSW	1	118543271	missense	probably damaging	0.99
R4707:Clasp1	UTSW	1	118543197	nonsense	probably null
R4809:Clasp1	UTSW	1	118461250	missense	probably benign	0.00
R4906:Clasp1	UTSW	1	118508910	nonsense	probably null
R5048:Clasp1	UTSW	1	118547610	intron	probably benign
R5298:Clasp1	UTSW	1	118547920	missense	possibly damaging	0.71
R5485:Clasp1	UTSW	1	118467913	missense	possibly damaging	0.95
R5516:Clasp1	UTSW	1	118497721	missense	probably damaging	1.00
R5821:Clasp1	UTSW	1	118590484	missense	probably damaging	1.00
R5911:Clasp1	UTSW	1	118506908	unclassified	probably benign
R6092:Clasp1	UTSW	1	118510298	missense	probably damaging	0.97
R6181:Clasp1	UTSW	1	118419817	missense	probably benign	0.18
R6478:Clasp1	UTSW	1	118512180	nonsense	probably null
R7090:Clasp1	UTSW	1	118482086	missense	probably benign	0.45
R7216:Clasp1	UTSW	1	118547918	missense	probably benign	0.00
R7508:Clasp1	UTSW	1	118545434	missense	probably benign	0.30
R7541:Clasp1	UTSW	1	118542997	splice site	probably null
R7644:Clasp1	UTSW	1	118512750	splice site	probably null
R7825:Clasp1	UTSW	1	118545393	missense	probably benign	0.00
R7910:Clasp1	UTSW	1	118602414	nonsense	probably null
R7971:Clasp1	UTSW	1	118521829	missense	probably damaging	0.99
R8074:Clasp1	UTSW	1	118462483	missense	probably benign
R8344:Clasp1	UTSW	1	118503899	missense	probably damaging	1.00
R8847:Clasp1	UTSW	1	118578975	missense	probably damaging	1.00
R9035:Clasp1	UTSW	1	118503853	missense	probably damaging	1.00
R9161:Clasp1	UTSW	1	118546921	missense	probably damaging	0.98
R9184:Clasp1	UTSW	1	118543178	missense	probably benign	0.17
R9379:Clasp1	UTSW	1	118581427	utr 3 prime	probably benign
R9379:Clasp1	UTSW	1	118581438	utr 3 prime	probably benign
R9422:Clasp1	UTSW	1	118462527	missense	possibly damaging	0.46
X0028:Clasp1	UTSW	1	118551125	missense	possibly damaging	0.93

Predicted Primers

PCR Primer
(F):5'- GACAGTGTGACATAGATTCCTGGCG -3'
(R):5'- ACAAAGGAAAGCTGGTCAACCCTG -3'

Sequencing Primer
(F):5'- TCCTCTCAGCAAGGTGAGAATG -3'
(R):5'- TGATCAGGAAAGACATCACACC -3'

Posted On

2014-01-29