Mutagenetix > Incidental Mutations

Incidental Mutation 'V7581:Gm10770'

152536

Institutional Source

Beutler Lab

Gene Symbol

Gm10770

Ensembl Gene

ENSMUSG00000074837

Gene Name

predicted gene 10770

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.197) question?

Stock #

V7581 () of strain stinger

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

150178882-150179679 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 150179484 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Stop codon at position 38 (K38*)

Ref Sequence

ENSEMBL: ENSMUSP00000097015 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099418] [ENSMUST00000109926]

AlphaFold

F7D043

Predicted Effect

probably null
Transcript: ENSMUST00000099418
AA Change: K38*

SMART Domains

Protein: ENSMUSP00000097015
Gene: ENSMUSG00000074837
AA Change: K38*

Domain	Start	End	E-Value	Type
ZnF_C2H2	12	34	8.09e0	SMART
ZnF_C2H2	40	62	8.4e1	SMART
ZnF_C2H2	68	90	1.12e-3	SMART
ZnF_C2H2	96	118	3.47e1	SMART
ZnF_C2H2	124	146	1.09e2	SMART
ZnF_C2H2	152	174	3.58e-2	SMART
ZnF_C2H2	180	202	6.23e-2	SMART
ZnF_C2H2	208	230	2.49e-1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000109926

SMART Domains

Protein: ENSMUSP00000105552
Gene: ENSMUSG00000079009

Domain	Start	End	E-Value	Type
Blast:KRAB	1	34	7e-15	BLAST
ZnF_C2H2	71	93	8.6e-5	SMART
ZnF_C2H2	99	121	1.76e-1	SMART
ZnF_C2H2	127	149	3.02e0	SMART
ZnF_C2H2	183	205	6.08e-5	SMART
ZnF_C2H2	211	233	1.04e-3	SMART
ZnF_C2H2	239	261	2.57e-3	SMART
ZnF_C2H2	267	289	1.06e-4	SMART
ZnF_C2H2	295	317	2.2e-2	SMART
ZnF_C2H2	323	345	4.47e-3	SMART
ZnF_C2H2	351	373	7.37e-4	SMART
ZnF_C2H2	379	401	4.24e-4	SMART
ZnF_C2H2	407	429	1.2e-3	SMART
ZnF_C2H2	435	457	2.61e-4	SMART

Meta Mutation Damage Score

0.9716

Coding Region Coverage

1x: 99.0%
3x: 98.2%
10x: 95.7%
20x: 90.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9530002B09Rik	A	T	4: 122,701,257	H102L	possibly damaging	Het
Abcb10	GGCCATCG	GG	8: 123,969,761		probably benign	Het
Atp6v1h	A	G	1: 5,124,443	T282A	possibly damaging	Het
Clasp1	G	A	1: 118,581,348	R1027Q	probably damaging	Het
D630003M21Rik	T	C	2: 158,201,011	T870A	probably benign	Het
Dnah12	T	A	14: 26,773,093	N1369K	possibly damaging	Het
Dnajc22	T	A	15: 99,101,482	Y183N	probably damaging	Het
Dpyd	C	T	3: 118,897,126	Q295*	probably null	Het
Erv3	T	C	2: 131,855,926	H171R	possibly damaging	Het
Fam221b	T	C	4: 43,665,865	T249A	probably benign	Het
Fcgr1	T	C	3: 96,284,276	*405W	probably null	Het
Glrx3	A	G	7: 137,459,153	H172R	probably benign	Het
Gm4787	G	A	12: 81,377,567	Q606*	probably null	Het
Hira	G	A	16: 18,894,821	A29T	probably damaging	Het
Hnrnpab	A	T	11: 51,602,624	N252K	probably benign	Het
Izumo4	A	T	10: 80,703,891	T155S	probably benign	Het
Kcnb2	A	G	1: 15,710,091	I396V	probably benign	Het
Klc1	A	T	12: 111,774,572	I161F	probably benign	Het
Lpar5	C	A	6: 125,081,727	A137E	possibly damaging	Het
Lrp4	C	T	2: 91,488,518	S900L	possibly damaging	Het
Muc6	T	G	7: 141,647,613	E808A	probably benign	Het
Olfr1406	G	T	1: 173,183,964	L157I	probably benign	Het
Olfr480	G	T	7: 108,066,678	T40K	probably benign	Het
Otop3	T	A	11: 115,344,838	L432Q	probably damaging	Het
Papln	C	T	12: 83,778,834	R608C	possibly damaging	Het
Pelp1	T	A	11: 70,398,150	T257S	probably damaging	Het
Pik3cd	A	C	4: 149,657,319	L390R	probably damaging	Het
Ppwd1	A	G	13: 104,220,237	Y257H	probably damaging	Het
Prkcb	G	T	7: 122,528,476	W274C	probably damaging	Het
Rbbp8nl	T	A	2: 180,278,208	T558S	probably benign	Het
Recql4	T	C	15: 76,706,169	D705G	possibly damaging	Het
Slc30a4	T	A	2: 122,689,538	M136L	probably benign	Het
Slc5a6	C	T	5: 31,042,613		probably null	Het
Spaca1	T	C	4: 34,039,311	E192G	probably damaging	Het
Spata31	C	A	13: 64,921,648	P537T	probably benign	Het
Tmc3	T	C	7: 83,622,505	V955A	probably benign	Het
Tnrc6c	G	A	11: 117,723,326	R770H	probably damaging	Het
Toe1	A	T	4: 116,806,111	N56K	probably damaging	Het
Tprkb	A	G	6: 85,928,782	K150E	probably damaging	Het
Trps1	T	C	15: 50,831,577	K150E	probably damaging	Het
Tspyl3	A	G	2: 153,225,060	V86A	probably benign	Het
Vmn2r68	C	T	7: 85,221,880	V732I	probably benign	Het
Wdr60	A	C	12: 116,211,840	S906A	possibly damaging	Het
Zfp292	C	T	4: 34,806,783	C2087Y	possibly damaging	Het
Zfp933	G	A	4: 147,826,470	A223V	probably damaging	Het
Zmynd8	G	A	2: 165,812,394	R724*	probably null	Het

Other mutations in Gm10770

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
F5770:Gm10770	UTSW	2	150179484	nonsense	probably null
R1765:Gm10770	UTSW	2	150179338	missense	probably damaging	1.00
R1842:Gm10770	UTSW	2	150179156	missense	probably damaging	1.00
R3438:Gm10770	UTSW	2	150179549	splice site	probably null
R4564:Gm10770	UTSW	2	150178911	missense	probably benign	0.00
R4863:Gm10770	UTSW	2	150178896	nonsense	probably null
R5134:Gm10770	UTSW	2	150179560	splice site	probably null
R5424:Gm10770	UTSW	2	150179028	missense	probably benign	0.01
R5429:Gm10770	UTSW	2	150179423	missense	probably benign	0.00
R5976:Gm10770	UTSW	2	150179400	nonsense	probably null
R6436:Gm10770	UTSW	2	150178910	missense	probably benign	0.07
R6679:Gm10770	UTSW	2	150179649	missense	probably damaging	1.00
V7580:Gm10770	UTSW	2	150179484	nonsense	probably null
V7583:Gm10770	UTSW	2	150179484	nonsense	probably null

Predicted Primers

Posted On

2014-01-29