|Institutional Source||Beutler Lab|
|Gene Name||ATP-binding cassette, sub-family B (MDR/TAP), member 10|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||V7581 () of strain stinger|
|Chromosomal Location||123952459-123983122 bp(-) (GRCm38)|
|Type of Mutation||intron|
|DNA Base Change (assembly)||GGCCATCG to GG at 123969761 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000118564 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000075578] [ENSMUST00000127664]|
|Coding Region Coverage||
FUNCTION: This gene encodes a member of the ATP-binding cassette superfamily of transporters. ATP-binding cassette proteins transport various molecules across extra- and intra-cellular membranes. The encoded protein is localized to the mitochondrial inner membrane where it interacts with and stabilizes mitoferrin-1, and is important for heme biosynthesis. Additional evidence suggests the encoded protein is involved in oxidative stress protection and erythropoisesis. [provided by RefSeq, May 2013]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality. Mice heterozygous for this allele exhibit increased response to ischemia and reperfusion. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Abcb10||
(F):5'- GGTGATGCCTTTGTCCCTACAGTC -3'
(R):5'- AGCTGATGTGCTCAGTCTACAAACG -3'
(F):5'- ACAGTCTGCGGCAATGTTC -3'
(R):5'- TCAGTCTACAAACGGGCTCTG -3'