Incidental Mutation 'V7582:Zfp933'
ID 152599
Institutional Source Beutler Lab
Gene Symbol Zfp933
Ensembl Gene ENSMUSG00000059423
Gene Name zinc finger protein 933
Synonyms 2810408P10Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # V7582 () of strain stinger
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 147907443-147932823 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 147910927 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 223 (A223V)
Ref Sequence ENSEMBL: ENSMUSP00000101343 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105718] [ENSMUST00000135798]
AlphaFold Q6PEE4
Predicted Effect probably damaging
Transcript: ENSMUST00000105718
AA Change: A223V

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000101343
Gene: ENSMUSG00000059423
AA Change: A223V

DomainStartEndE-ValueType
KRAB 4 66 9.49e-16 SMART
ZnF_C2H2 131 153 3.21e-4 SMART
ZnF_C2H2 159 181 5.21e-4 SMART
ZnF_C2H2 187 209 2.12e-4 SMART
ZnF_C2H2 215 237 7.26e-3 SMART
ZnF_C2H2 243 265 6.88e-4 SMART
ZnF_C2H2 271 293 1.13e-4 SMART
ZnF_C2H2 299 321 3.95e-4 SMART
ZnF_C2H2 327 349 1.56e-2 SMART
ZnF_C2H2 355 377 1.79e-2 SMART
ZnF_C2H2 383 405 4.24e-4 SMART
ZnF_C2H2 411 433 1.22e-4 SMART
ZnF_C2H2 439 461 4.79e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000116174
Predicted Effect probably benign
Transcript: ENSMUST00000135798
SMART Domains Protein: ENSMUSP00000118300
Gene: ENSMUSG00000059423

DomainStartEndE-ValueType
Blast:KRAB 1 34 8e-18 BLAST
PDB:2I13|B 32 98 1e-12 PDB
SCOP:d1fgja_ 33 98 5e-13 SMART
Blast:PHD 44 98 6e-11 BLAST
Meta Mutation Damage Score 0.2168 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.7%
  • 20x: 90.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530002B09Rik A T 4: 122,595,050 (GRCm39) H102L possibly damaging Het
Ahcy G A 2: 154,906,841 (GRCm39) R151* probably null Het
Atp6v1h A G 1: 5,194,666 (GRCm39) T282A possibly damaging Het
Cdc42bpb C T 12: 111,262,825 (GRCm39) G1501S probably benign Het
Dnajc22 T A 15: 98,999,363 (GRCm39) Y183N probably damaging Het
Dpyd C T 3: 118,690,775 (GRCm39) Q295* probably null Het
Dync2i1 A C 12: 116,175,460 (GRCm39) S906A possibly damaging Het
Erv3 T C 2: 131,697,846 (GRCm39) H171R possibly damaging Het
Fam221b T C 4: 43,665,865 (GRCm39) T249A probably benign Het
Fbrsl1 C T 5: 110,527,292 (GRCm39) A129T possibly damaging Het
Fcgr1 T C 3: 96,191,592 (GRCm39) *405W probably null Het
Gm4787 G A 12: 81,424,341 (GRCm39) Q606* probably null Het
Hira G A 16: 18,713,571 (GRCm39) A29T probably damaging Het
Izumo4 A T 10: 80,539,725 (GRCm39) T155S probably benign Het
Kcnb2 A G 1: 15,780,315 (GRCm39) I396V probably benign Het
Lpar5 C A 6: 125,058,690 (GRCm39) A137E possibly damaging Het
Lrp4 C T 2: 91,318,863 (GRCm39) S900L possibly damaging Het
Med20 G A 17: 47,929,757 (GRCm39) V65M probably damaging Het
Myrfl T C 10: 116,697,435 (GRCm39) T30A probably damaging Het
Or10j7 G T 1: 173,011,531 (GRCm39) L157I probably benign Het
Otop3 T A 11: 115,235,664 (GRCm39) L432Q probably damaging Het
Papln C T 12: 83,825,608 (GRCm39) R608C possibly damaging Het
Pelp1 T A 11: 70,288,976 (GRCm39) T257S probably damaging Het
Pik3cd A C 4: 149,741,776 (GRCm39) L390R probably damaging Het
Plekhb1 T C 7: 100,303,825 (GRCm39) T112A probably benign Het
Rbbp8nl T A 2: 179,920,001 (GRCm39) T558S probably benign Het
Rundc3b TGCCGCCGCCGCCGCCGCCGCCGCCGC TGCCGCCGCCGCCGCCGCCGCCGC 5: 8,672,549 (GRCm39) probably benign Het
Slc30a4 T A 2: 122,531,458 (GRCm39) M136L probably benign Het
Spaca1 T C 4: 34,039,311 (GRCm39) E192G probably damaging Het
Thbd A T 2: 148,249,110 (GRCm39) Y253N probably benign Het
Tiam1 C T 16: 89,662,159 (GRCm39) R653H probably damaging Het
Tnrc6c G A 11: 117,614,152 (GRCm39) R770H probably damaging Het
Toe1 A T 4: 116,663,308 (GRCm39) N56K probably damaging Het
Tprkb A G 6: 85,905,764 (GRCm39) K150E probably damaging Het
Zfp292 C T 4: 34,806,783 (GRCm39) C2087Y possibly damaging Het
Other mutations in Zfp933
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00576:Zfp933 APN 4 147,910,778 (GRCm39) missense probably damaging 1.00
IGL03377:Zfp933 APN 4 147,913,168 (GRCm39) missense possibly damaging 0.65
F5770:Zfp933 UTSW 4 147,910,927 (GRCm39) missense probably damaging 0.98
FR4340:Zfp933 UTSW 4 147,910,186 (GRCm39) frame shift probably null
FR4548:Zfp933 UTSW 4 147,910,188 (GRCm39) frame shift probably null
R0388:Zfp933 UTSW 4 147,910,899 (GRCm39) missense probably benign 0.35
R0523:Zfp933 UTSW 4 147,910,919 (GRCm39) nonsense probably null
R0539:Zfp933 UTSW 4 147,911,005 (GRCm39) missense probably benign 0.08
R1672:Zfp933 UTSW 4 147,910,476 (GRCm39) missense probably damaging 1.00
R4049:Zfp933 UTSW 4 147,910,969 (GRCm39) missense probably damaging 1.00
R4895:Zfp933 UTSW 4 147,910,892 (GRCm39) nonsense probably null
R5133:Zfp933 UTSW 4 147,911,321 (GRCm39) missense probably benign
R5786:Zfp933 UTSW 4 147,912,864 (GRCm39) splice site probably null
R5891:Zfp933 UTSW 4 147,911,231 (GRCm39) missense probably benign 0.03
R6111:Zfp933 UTSW 4 147,913,217 (GRCm39) missense probably damaging 1.00
R6382:Zfp933 UTSW 4 147,910,325 (GRCm39) missense probably benign 0.07
R6968:Zfp933 UTSW 4 147,910,654 (GRCm39) missense probably damaging 1.00
R7195:Zfp933 UTSW 4 147,910,636 (GRCm39) missense probably benign 0.16
R7555:Zfp933 UTSW 4 147,910,589 (GRCm39) missense probably damaging 1.00
R7902:Zfp933 UTSW 4 147,911,058 (GRCm39) missense probably damaging 0.96
R8319:Zfp933 UTSW 4 147,912,910 (GRCm39) missense possibly damaging 0.87
R8688:Zfp933 UTSW 4 147,911,249 (GRCm39) missense probably benign 0.14
R9019:Zfp933 UTSW 4 147,911,021 (GRCm39) missense probably damaging 1.00
RF024:Zfp933 UTSW 4 147,910,898 (GRCm39) missense probably damaging 1.00
RF028:Zfp933 UTSW 4 147,910,188 (GRCm39) frame shift probably null
RF035:Zfp933 UTSW 4 147,910,188 (GRCm39) makesense probably null
RF043:Zfp933 UTSW 4 147,910,188 (GRCm39) frame shift probably null
V7581:Zfp933 UTSW 4 147,910,927 (GRCm39) missense probably damaging 0.98
V7583:Zfp933 UTSW 4 147,910,927 (GRCm39) missense probably damaging 0.98
Predicted Primers
Posted On 2014-01-29