Incidental Mutation 'V7583:Fcgr1'
ID 152638
Institutional Source Beutler Lab
Gene Symbol Fcgr1
Ensembl Gene ENSMUSG00000015947
Gene Name Fc receptor, IgG, high affinity I
Synonyms CD64, FcgammaRI
Accession Numbers
Essential gene? Probably non essential (E-score: 0.177) question?
Stock # V7583 () of strain stinger
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 96190225-96201285 bp(-) (GRCm39)
Type of Mutation makesense
DNA Base Change (assembly) T to C at 96191592 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Stop codon to Tryptophan at position 405 (*405W)
Ref Sequence ENSEMBL: ENSMUSP00000029748 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029748]
AlphaFold P26151
Predicted Effect probably null
Transcript: ENSMUST00000029748
AA Change: *405W
SMART Domains Protein: ENSMUSP00000029748
Gene: ENSMUSG00000015947
AA Change: *405W

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
IG 38 111 1.8e-5 SMART
IGc2 125 184 6.11e-8 SMART
IG 206 290 7.3e-6 SMART
transmembrane domain 298 320 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000200420
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutation of this gene results immune response defects including a decreased inflammatory response. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530002B09Rik A T 4: 122,595,050 (GRCm39) H102L possibly damaging Het
Atp6v1h A G 1: 5,194,666 (GRCm39) T282A possibly damaging Het
Cdc42bpb C T 12: 111,262,825 (GRCm39) G1501S probably benign Het
D630003M21Rik T C 2: 158,042,931 (GRCm39) T870A probably benign Het
Dcaf4 C A 12: 83,584,475 (GRCm39) probably null Het
Dnajc22 T A 15: 98,999,363 (GRCm39) Y183N probably damaging Het
Dpyd C T 3: 118,690,775 (GRCm39) Q295* probably null Het
Dync2i1 A C 12: 116,175,460 (GRCm39) S906A possibly damaging Het
Erv3 T C 2: 131,697,846 (GRCm39) H171R possibly damaging Het
Fam221b T C 4: 43,665,865 (GRCm39) T249A probably benign Het
Gm10770 T A 2: 150,021,404 (GRCm39) K38* probably null Het
Golga4 A G 9: 118,385,143 (GRCm39) E727G possibly damaging Het
Hnrnpab A T 11: 51,493,451 (GRCm39) N252K probably benign Het
Ing1 T C 8: 11,611,934 (GRCm39) V124A probably damaging Het
Izumo4 A T 10: 80,539,725 (GRCm39) T155S probably benign Het
Kcnb2 A G 1: 15,780,315 (GRCm39) I396V probably benign Het
Lrp4 C T 2: 91,318,863 (GRCm39) S900L possibly damaging Het
Mbd5 A G 2: 49,206,422 (GRCm39) D1713G probably damaging Het
Muc6 T G 7: 141,233,880 (GRCm39) E808A probably benign Het
Mylk G T 16: 34,815,574 (GRCm39) probably null Het
Nbeal2 A G 9: 110,467,005 (GRCm39) V670A possibly damaging Het
Nphp3 T C 9: 103,913,093 (GRCm39) probably null Het
Numbl T C 7: 26,979,027 (GRCm39) S379P probably benign Het
Otop3 T A 11: 115,235,664 (GRCm39) L432Q probably damaging Het
Pelp1 T A 11: 70,288,976 (GRCm39) T257S probably damaging Het
Pigx T C 16: 31,906,240 (GRCm39) D129G probably damaging Het
Pik3cd A C 4: 149,741,776 (GRCm39) L390R probably damaging Het
Plekhb1 T C 7: 100,303,825 (GRCm39) T112A probably benign Het
Recql4 T C 15: 76,590,369 (GRCm39) D705G possibly damaging Het
Ror1 A G 4: 100,298,130 (GRCm39) Q501R probably damaging Het
Sirpb1b A G 3: 15,568,243 (GRCm39) V366A probably benign Het
Slc30a4 T A 2: 122,531,458 (GRCm39) M136L probably benign Het
Spaca1 T C 4: 34,039,311 (GRCm39) E192G probably damaging Het
Spata31 C A 13: 65,069,462 (GRCm39) P537T probably benign Het
Tnrc6c G A 11: 117,614,152 (GRCm39) R770H probably damaging Het
Toe1 A T 4: 116,663,308 (GRCm39) N56K probably damaging Het
Tprkb A G 6: 85,905,764 (GRCm39) K150E probably damaging Het
Trps1 T C 15: 50,694,973 (GRCm39) K150E probably damaging Het
Tspyl3 A G 2: 153,066,980 (GRCm39) V86A probably benign Het
Vps18 A G 2: 119,127,709 (GRCm39) Y844C probably benign Het
Wdr72 T A 9: 74,064,552 (GRCm39) I528N probably damaging Het
Zfp292 C T 4: 34,806,783 (GRCm39) C2087Y possibly damaging Het
Zfp933 G A 4: 147,910,927 (GRCm39) A223V probably damaging Het
Zmynd8 G A 2: 165,654,314 (GRCm39) R724* probably null Het
Other mutations in Fcgr1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01490:Fcgr1 APN 3 96,191,686 (GRCm39) missense probably benign 0.01
IGL02142:Fcgr1 APN 3 96,191,893 (GRCm39) missense probably benign 0.41
IGL03086:Fcgr1 APN 3 96,191,814 (GRCm39) nonsense probably null
F5770:Fcgr1 UTSW 3 96,191,592 (GRCm39) makesense probably null
FR4737:Fcgr1 UTSW 3 96,194,410 (GRCm39) missense probably benign 0.01
FR4737:Fcgr1 UTSW 3 96,191,820 (GRCm39) frame shift probably null
R0323:Fcgr1 UTSW 3 96,193,145 (GRCm39) missense possibly damaging 0.84
R0594:Fcgr1 UTSW 3 96,199,628 (GRCm39) missense probably damaging 1.00
R0926:Fcgr1 UTSW 3 96,199,682 (GRCm39) missense possibly damaging 0.79
R1951:Fcgr1 UTSW 3 96,194,386 (GRCm39) missense probably damaging 1.00
R1953:Fcgr1 UTSW 3 96,194,386 (GRCm39) missense probably damaging 1.00
R1993:Fcgr1 UTSW 3 96,193,184 (GRCm39) missense probably damaging 0.98
R2255:Fcgr1 UTSW 3 96,193,233 (GRCm39) missense possibly damaging 0.88
R3941:Fcgr1 UTSW 3 96,193,349 (GRCm39) missense probably benign 0.13
R4004:Fcgr1 UTSW 3 96,191,668 (GRCm39) missense probably benign 0.00
R4409:Fcgr1 UTSW 3 96,191,893 (GRCm39) missense probably benign 0.41
R5046:Fcgr1 UTSW 3 96,194,302 (GRCm39) missense probably damaging 0.99
R5047:Fcgr1 UTSW 3 96,193,200 (GRCm39) missense probably benign 0.38
R6970:Fcgr1 UTSW 3 96,191,936 (GRCm39) critical splice acceptor site probably null
R7339:Fcgr1 UTSW 3 96,191,615 (GRCm39) missense not run
R7992:Fcgr1 UTSW 3 96,191,897 (GRCm39) missense probably benign 0.23
R8554:Fcgr1 UTSW 3 96,199,788 (GRCm39) missense probably damaging 1.00
R9269:Fcgr1 UTSW 3 96,193,154 (GRCm39) missense probably benign 0.01
R9396:Fcgr1 UTSW 3 96,194,390 (GRCm39) nonsense probably null
V7581:Fcgr1 UTSW 3 96,191,592 (GRCm39) makesense probably null
V7582:Fcgr1 UTSW 3 96,191,592 (GRCm39) makesense probably null
X0028:Fcgr1 UTSW 3 96,193,343 (GRCm39) missense probably benign 0.29
Predicted Primers PCR Primer
(F):5'- TTCCGATGCTCTCAGGATGACCAC -3'
(R):5'- CTTTCAGCAAGTTAGAAGCGATGGC -3'

Sequencing Primer
(F):5'- TCTCAGACTGGAGTCTTCCAGAG -3'
(R):5'- CGTGTATGAAGAAGTAACAGCCAC -3'
Posted On 2014-01-29