Incidental Mutation 'R1081:Mob1b'
ID 152685
Institutional Source Beutler Lab
Gene Symbol Mob1b
Ensembl Gene ENSMUSG00000006262
Gene Name MOB kinase activator 1B
Synonyms 1110003E08Rik, Mobkl1a
MMRRC Submission 039167-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.161) question?
Stock # R1081 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 88868730-88906314 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 88901021 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 143 (V143I)
Ref Sequence ENSEMBL: ENSMUSP00000108855 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006424] [ENSMUST00000113229]
AlphaFold Q8BPB0
Predicted Effect probably benign
Transcript: ENSMUST00000006424
AA Change: V138I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000006424
Gene: ENSMUSG00000006262
AA Change: V138I

DomainStartEndE-ValueType
Pfam:Mob1_phocein 29 205 1.2e-83 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000113229
AA Change: V143I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000108855
Gene: ENSMUSG00000006262
AA Change: V143I

DomainStartEndE-ValueType
Mob1_phocein 31 209 2.18e-113 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125171
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155298
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 91.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit no abnormal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700003E16Rik A G 6: 83,139,002 (GRCm39) E309G probably benign Het
Abr T C 11: 76,346,441 (GRCm39) K448E probably damaging Het
Atxn2l T C 7: 126,093,384 (GRCm39) Y785C probably damaging Het
Atxn3 T G 12: 101,900,608 (GRCm39) D225A probably damaging Het
Cdh15 G C 8: 123,584,234 (GRCm39) E112Q probably damaging Het
Cntnap5c A G 17: 58,612,520 (GRCm39) D853G possibly damaging Het
Dnah9 A G 11: 65,975,703 (GRCm39) Y1449H probably damaging Het
Dsc2 T G 18: 20,166,352 (GRCm39) T760P probably damaging Het
Dync2h1 A T 9: 7,005,488 (GRCm39) probably null Het
Epg5 T C 18: 78,002,748 (GRCm39) F611L possibly damaging Het
Fat3 T C 9: 16,286,580 (GRCm39) D981G possibly damaging Het
Gimap3 A T 6: 48,742,086 (GRCm39) C281* probably null Het
Ids T C X: 69,404,716 (GRCm39) D149G possibly damaging Het
Inpp4b A G 8: 82,795,653 (GRCm39) I826V probably damaging Het
Kcnrg C A 14: 61,845,163 (GRCm39) H68N possibly damaging Het
Klra6 A G 6: 129,999,588 (GRCm39) Y127H probably damaging Het
Lypd10 T C 7: 24,412,967 (GRCm39) probably null Het
Mepce A G 5: 137,782,958 (GRCm39) L456P probably damaging Het
Mink1 T C 11: 70,497,861 (GRCm39) L488P probably benign Het
Mndal T A 1: 173,687,788 (GRCm39) E482V probably benign Het
Msh4 T C 3: 153,577,995 (GRCm39) E433G probably benign Het
Myof A T 19: 37,974,536 (GRCm39) I201N probably damaging Het
Naip1 G A 13: 100,559,578 (GRCm39) S1142F probably benign Het
Ntsr1 G A 2: 180,180,549 (GRCm39) S285N probably benign Het
Or2ak6 C T 11: 58,593,324 (GRCm39) H266Y probably damaging Het
Or4k2 A G 14: 50,424,654 (GRCm39) S7P probably damaging Het
Or51b4 T A 7: 103,531,384 (GRCm39) H22L possibly damaging Het
Or52ab7 A G 7: 102,978,245 (GRCm39) Y184C probably damaging Het
P2rx4 A G 5: 122,865,296 (GRCm39) E307G probably damaging Het
Pcdh15 A G 10: 74,286,145 (GRCm39) D793G probably damaging Het
Rpap1 G A 2: 119,601,750 (GRCm39) R737W probably damaging Het
Rpusd4 A G 9: 35,186,384 (GRCm39) K307E probably benign Het
Shtn1 T A 19: 58,963,447 (GRCm39) T623S probably benign Het
Sntg1 A G 1: 8,515,343 (GRCm39) C397R possibly damaging Het
Stat5a T C 11: 100,771,886 (GRCm39) F646S probably damaging Het
Tacc2 A G 7: 130,330,304 (GRCm39) E196G possibly damaging Het
Tcf25 T C 8: 124,108,212 (GRCm39) V89A probably benign Het
Trim7 G T 11: 48,740,532 (GRCm39) V210L probably damaging Het
Vmn2r57 A G 7: 41,077,635 (GRCm39) M177T possibly damaging Het
Wwc2 G A 8: 48,281,799 (GRCm39) probably benign Het
Zfp28 A G 7: 6,392,779 (GRCm39) I152V possibly damaging Het
Zfp628 A G 7: 4,923,182 (GRCm39) H468R probably damaging Het
Zfp770 A G 2: 114,027,608 (GRCm39) Y154H probably damaging Het
Other mutations in Mob1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Mob1b APN 5 88,904,014 (GRCm39) missense probably benign 0.00
IGL01475:Mob1b APN 5 88,897,502 (GRCm39) missense probably damaging 1.00
IGL02478:Mob1b APN 5 88,903,947 (GRCm39) splice site probably benign
R0012:Mob1b UTSW 5 88,903,943 (GRCm39) splice site probably benign
R0012:Mob1b UTSW 5 88,903,943 (GRCm39) splice site probably benign
R0938:Mob1b UTSW 5 88,897,452 (GRCm39) missense probably damaging 1.00
R3500:Mob1b UTSW 5 88,897,479 (GRCm39) missense probably benign 0.00
R3890:Mob1b UTSW 5 88,901,061 (GRCm39) missense probably damaging 0.97
R3891:Mob1b UTSW 5 88,901,061 (GRCm39) missense probably damaging 0.97
R3892:Mob1b UTSW 5 88,901,061 (GRCm39) missense probably damaging 0.97
R7243:Mob1b UTSW 5 88,891,304 (GRCm39) missense probably damaging 0.96
R7302:Mob1b UTSW 5 88,901,036 (GRCm39) missense probably benign
R7782:Mob1b UTSW 5 88,897,542 (GRCm39) splice site probably null
R8101:Mob1b UTSW 5 88,901,093 (GRCm39) missense probably benign 0.10
R9160:Mob1b UTSW 5 88,904,017 (GRCm39) missense probably benign 0.08
Predicted Primers PCR Primer
(F):5'- tccccCAAGGGCAAATTTCATTTTAGt -3'
(R):5'- GCTTAATGAGTCAACCTACCTGAACGAA -3'

Sequencing Primer
(F):5'- cttgaactcagaaatccgcc -3'
(R):5'- TACCTGAACGAAAAAAATAAAGTGC -3'
Posted On 2014-01-29