|Institutional Source||Beutler Lab|
|Gene Name||maestro heat-like repeat family member 8|
|Is this an essential gene?||Probably essential (E-score: 0.904)|
|Stock #||R1222 (G1)|
|Chromosomal Location||157208550-157279549 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||G to A at 157241854 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000124362 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000143663]|
|Predicted Effect||probably benign
|Predicted Effect||noncoding transcript
|Coding Region Coverage||
|Validation Efficiency||96% (54/56)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the maestro heat-like repeat family. The exact function of this gene is not known, however, in a genome-wide association study using hippocampal atrophy as a quantitative trait, this gene has been associated with Alzheimer's disease (PMID:19668339). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Mroh8||
(F):5'- AGATCCCACCTTCATTCCACAGTGT -3'
(R):5'- GCTGTTGGGTTCTGAGAAAGGATACAT -3'
(F):5'- CAGTGTCTTACATTTCAGTCTCAGAG -3'
(R):5'- accaaccaaacaaacaaacaaac -3'