Incidental Mutation 'R1225:Or2t6'
ID 152881
Institutional Source Beutler Lab
Gene Symbol Or2t6
Ensembl Gene ENSMUSG00000052417
Gene Name olfactory receptor family 2 subfamily T member 6
Synonyms Olfr720, MOR274-2, GA_x6K02T2PLTE-6544896-6543946
MMRRC Submission 039294-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.286) question?
Stock # R1225 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 8293683-8294633 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 14175600 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 161 (I161F)
Ref Sequence ENSEMBL: ENSMUSP00000149641 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035250] [ENSMUST00000206298] [ENSMUST00000216079] [ENSMUST00000217642]
AlphaFold Q8VF37
Predicted Effect possibly damaging
Transcript: ENSMUST00000035250
AA Change: I161F

PolyPhen 2 Score 0.890 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000046509
Gene: ENSMUSG00000052417
AA Change: I161F

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 8.4e-49 PFAM
Pfam:7tm_1 40 289 8.9e-25 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000206298
AA Change: I161F

PolyPhen 2 Score 0.890 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000216079
AA Change: I161F

PolyPhen 2 Score 0.890 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217642
AA Change: I161F

PolyPhen 2 Score 0.890 (Sensitivity: 0.82; Specificity: 0.94)
Meta Mutation Damage Score 0.1010 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.5%
  • 20x: 93.3%
Validation Efficiency 100% (43/43)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A730013G03Rik T A 1: 192,515,953 (GRCm39) noncoding transcript Het
Abcb10 C T 8: 124,688,791 (GRCm39) G495D probably damaging Het
Ahnak T A 19: 8,980,247 (GRCm39) D510E probably damaging Het
Angptl4 C T 17: 34,000,165 (GRCm39) A68T possibly damaging Het
Arid1a A G 4: 133,414,676 (GRCm39) V1185A unknown Het
Atp2c2 C A 8: 120,461,984 (GRCm39) Q286K probably damaging Het
Blzf1 T C 1: 164,127,165 (GRCm39) E209G probably damaging Het
Bmp6 A G 13: 38,530,257 (GRCm39) T117A probably benign Het
Cmip T C 8: 118,172,110 (GRCm39) F394L probably damaging Het
Col6a3 T A 1: 90,739,238 (GRCm39) D330V probably damaging Het
Crebbp A T 16: 3,944,820 (GRCm39) S491R probably benign Het
Dedd G A 1: 171,167,863 (GRCm39) probably null Het
Dennd4a A G 9: 64,818,957 (GRCm39) H1704R probably benign Het
Dicer1 C T 12: 104,657,866 (GRCm39) V1903I probably damaging Het
Dnah9 A G 11: 65,761,886 (GRCm39) V3868A possibly damaging Het
Eif5b A G 1: 38,076,709 (GRCm39) I674V probably damaging Het
F13a1 T C 13: 37,209,825 (GRCm39) N47D probably benign Het
Fancd2 T C 6: 113,512,822 (GRCm39) S53P probably damaging Het
Fsip1 C A 2: 118,078,831 (GRCm39) L170F probably damaging Het
Git2 A T 5: 114,871,239 (GRCm39) probably benign Het
Gm9742 T C 13: 8,079,875 (GRCm39) noncoding transcript Het
Heatr4 C T 12: 84,024,820 (GRCm39) E334K probably benign Het
Hoga1 T G 19: 42,058,628 (GRCm39) V110G probably damaging Het
Ighv6-4 T A 12: 114,370,170 (GRCm39) D75V probably damaging Het
Inhca A T 9: 103,132,038 (GRCm39) probably benign Het
Med15 G T 16: 17,540,652 (GRCm39) S31R probably damaging Het
Nbeal2 T C 9: 110,461,954 (GRCm39) E1467G probably damaging Het
Or2ag1 A T 7: 106,313,731 (GRCm39) D52E probably benign Het
Or5ac19 T C 16: 59,089,587 (GRCm39) T148A probably benign Het
Papss1 T C 3: 131,285,062 (GRCm39) probably benign Het
Pde4d A T 13: 110,086,755 (GRCm39) M610L probably benign Het
Prickle4 T G 17: 47,999,614 (GRCm39) probably null Het
Sema3g A G 14: 30,942,636 (GRCm39) Y79C probably damaging Het
Setbp1 T A 18: 78,901,423 (GRCm39) D748V probably damaging Het
Slc46a2 A T 4: 59,914,125 (GRCm39) V266E probably benign Het
Slc9a8 T C 2: 167,313,443 (GRCm39) I435T probably benign Het
Snx29 T C 16: 11,238,550 (GRCm39) probably benign Het
Son C T 16: 91,454,228 (GRCm39) R992C probably damaging Het
Stxbp5 T C 10: 9,688,135 (GRCm39) N389D possibly damaging Het
Vmn1r28 C T 6: 58,242,951 (GRCm39) Q265* probably null Het
Other mutations in Or2t6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02658:Or2t6 APN 14 14,175,732 (GRCm38) missense possibly damaging 0.92
IGL02704:Or2t6 APN 14 14,175,483 (GRCm38) missense probably benign 0.00
IGL03308:Or2t6 APN 14 14,175,161 (GRCm38) missense probably benign
IGL03331:Or2t6 APN 14 14,176,017 (GRCm38) missense probably benign 0.16
R0008:Or2t6 UTSW 14 14,176,092 (GRCm38) start gained probably benign
R0131:Or2t6 UTSW 14 14,175,620 (GRCm38) missense probably benign 0.03
R0647:Or2t6 UTSW 14 14,175,858 (GRCm38) missense probably benign 0.35
R0747:Or2t6 UTSW 14 14,175,429 (GRCm38) missense probably benign 0.01
R1210:Or2t6 UTSW 14 14,176,029 (GRCm38) missense probably benign 0.00
R1525:Or2t6 UTSW 14 14,175,725 (GRCm38) missense probably damaging 1.00
R1975:Or2t6 UTSW 14 14,175,446 (GRCm38) missense probably damaging 1.00
R1994:Or2t6 UTSW 14 14,175,854 (GRCm38) missense probably benign 0.16
R2310:Or2t6 UTSW 14 14,175,836 (GRCm38) missense probably benign 0.03
R3151:Or2t6 UTSW 14 14,175,203 (GRCm38) missense probably damaging 1.00
R4547:Or2t6 UTSW 14 14,175,854 (GRCm38) missense probably damaging 0.99
R4824:Or2t6 UTSW 14 14,175,885 (GRCm38) missense probably damaging 1.00
R5063:Or2t6 UTSW 14 14,175,593 (GRCm38) missense probably damaging 1.00
R5098:Or2t6 UTSW 14 14,175,683 (GRCm38) missense probably benign 0.03
R5430:Or2t6 UTSW 14 14,175,692 (GRCm38) missense probably benign 0.03
R5512:Or2t6 UTSW 14 14,175,633 (GRCm38) missense probably damaging 1.00
R5748:Or2t6 UTSW 14 14,175,314 (GRCm38) missense probably damaging 1.00
R7200:Or2t6 UTSW 14 14,175,477 (GRCm38) missense probably damaging 1.00
R7407:Or2t6 UTSW 14 14,175,402 (GRCm38) missense probably benign
R7666:Or2t6 UTSW 14 14,176,075 (GRCm38) missense probably benign
R7760:Or2t6 UTSW 14 14,175,905 (GRCm38) missense probably damaging 1.00
R8118:Or2t6 UTSW 14 14,175,863 (GRCm38) missense probably damaging 1.00
R8413:Or2t6 UTSW 14 14,175,416 (GRCm38) missense probably benign 0.00
R8873:Or2t6 UTSW 14 14,175,344 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGGTGGCAAAAGCCTTCTTCCTC -3'
(R):5'- CCAGTGACTTCACCTTTGTGGGAC -3'

Sequencing Primer
(F):5'- CTGTGACCAGTATCTGGGCATAAG -3'
(R):5'- AAAGCCTCAGGATTCCTGTTCAG -3'
Posted On 2014-01-29