Incidental Mutation 'IGL01744:Prss39'
ID152990
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prss39
Ensembl Gene ENSMUSG00000026125
Gene Nameprotease, serine 39
SynonymsTesp1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.098) question?
Stock #IGL01744
Quality Score
Status
Chromosome1
Chromosomal Location34498410-34503063 bp(+) (GRCm38)
Type of Mutationsplice site (3 bp from exon)
DNA Base Change (assembly) A to G at 34502199 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000027299 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027299] [ENSMUST00000191604]
Predicted Effect probably null
Transcript: ENSMUST00000027299
SMART Domains Protein: ENSMUSP00000027299
Gene: ENSMUSG00000026125

DomainStartEndE-ValueType
signal peptide 1 31 N/A INTRINSIC
low complexity region 35 47 N/A INTRINSIC
Tryp_SPc 67 307 7.97e-60 SMART
low complexity region 348 361 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000191604
SMART Domains Protein: ENSMUSP00000140460
Gene: ENSMUSG00000026125

DomainStartEndE-ValueType
signal peptide 1 31 N/A INTRINSIC
low complexity region 35 47 N/A INTRINSIC
Pfam:Trypsin 68 114 1.5e-12 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900092C05Rik T C 7: 12,550,532 I102T possibly damaging Het
4933412E24Rik C A 15: 60,015,575 A339S possibly damaging Het
Ackr2 A G 9: 121,909,119 T187A probably benign Het
Adam28 A G 14: 68,607,507 V777A probably benign Het
Add3 T A 19: 53,239,430 D515E probably damaging Het
Aire C A 10: 78,036,723 E354* probably null Het
AW551984 T C 9: 39,591,272 K670R probably benign Het
Bahcc1 T C 11: 120,271,737 V287A probably benign Het
Brca1 T C 11: 101,524,176 N1044S possibly damaging Het
Bub1b T A 2: 118,636,749 I851N probably damaging Het
Ceacam11 A T 7: 17,973,398 I36F possibly damaging Het
Copa A G 1: 172,113,189 E714G probably benign Het
Cth A T 3: 157,924,935 N32K probably benign Het
Cyp2a5 T A 7: 26,841,009 M349K probably damaging Het
D130052B06Rik A G 11: 33,623,966 S188G unknown Het
Fhdc1 G A 3: 84,444,735 A1061V possibly damaging Het
Flt1 T C 5: 147,571,461 N1161S probably benign Het
Gm10696 T A 3: 94,176,237 K89M probably damaging Het
Hip1 T C 5: 135,545,063 probably benign Het
Mapk11 A G 15: 89,146,843 probably benign Het
Mtif2 A G 11: 29,544,417 probably benign Het
Myo1f C A 17: 33,583,680 probably benign Het
Nipsnap1 G A 11: 4,889,912 R211H probably damaging Het
Olfr599 A G 7: 103,338,228 H58R probably damaging Het
Olfr781 T C 10: 129,333,457 I192T probably benign Het
Pcdh1 A T 18: 38,203,249 I111N probably damaging Het
Piezo2 T A 18: 63,042,788 I1841F probably damaging Het
Pirb G T 7: 3,717,176 Y399* probably null Het
Ppp1r36 A T 12: 76,439,232 N388I possibly damaging Het
Prr16 A G 18: 51,302,989 D180G possibly damaging Het
Trank1 T A 9: 111,349,363 V373D probably damaging Het
Ubn1 A G 16: 5,072,059 E186G probably damaging Het
Zmym2 T C 14: 56,946,572 V997A probably benign Het
Other mutations in Prss39
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01432:Prss39 APN 1 34502135 missense probably benign 0.01
IGL01468:Prss39 APN 1 34499400 splice site probably benign
IGL02224:Prss39 APN 1 34499378 missense probably damaging 1.00
R0128:Prss39 UTSW 1 34502200 unclassified probably benign
R0130:Prss39 UTSW 1 34502200 unclassified probably benign
R0269:Prss39 UTSW 1 34500198 missense probably damaging 0.96
R0617:Prss39 UTSW 1 34500198 missense probably damaging 0.96
R1078:Prss39 UTSW 1 34502086 missense probably benign 0.00
R1539:Prss39 UTSW 1 34498535 missense possibly damaging 0.85
R1796:Prss39 UTSW 1 34500033 missense possibly damaging 0.70
R4644:Prss39 UTSW 1 34502126 missense probably damaging 0.96
R5417:Prss39 UTSW 1 34500128 missense probably benign
R5496:Prss39 UTSW 1 34500261 missense possibly damaging 0.92
R5511:Prss39 UTSW 1 34502797 missense possibly damaging 0.65
R5977:Prss39 UTSW 1 34502702 missense probably damaging 1.00
R6333:Prss39 UTSW 1 34500069 missense probably benign 0.02
R6833:Prss39 UTSW 1 34498616 missense possibly damaging 0.84
R6834:Prss39 UTSW 1 34498616 missense possibly damaging 0.84
R7230:Prss39 UTSW 1 34502147 missense probably damaging 0.98
R7261:Prss39 UTSW 1 34500288 missense probably damaging 0.99
R7467:Prss39 UTSW 1 34499392 critical splice donor site probably null
R7509:Prss39 UTSW 1 34500199 missense possibly damaging 0.85
R7709:Prss39 UTSW 1 34502628 missense probably damaging 1.00
R7894:Prss39 UTSW 1 34500227 missense probably benign 0.16
R7977:Prss39 UTSW 1 34500227 missense probably benign 0.16
Posted On2014-02-04