Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01748:Vmn2r108'

153063

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r108

Ensembl Gene

ENSMUSG00000091805

Gene Name

vomeronasal 2, receptor 108

Synonyms

EG627805

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.061) question?

Stock #

IGL01748

Quality Score

Status

Chromosome

Chromosomal Location

20682635-20701498 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 20683476 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 576 (I576N)

Ref Sequence

ENSEMBL: ENSMUSP00000130373 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167314]

AlphaFold

E9PYS0

Predicted Effect

probably benign
Transcript: ENSMUST00000167314
AA Change: I576N

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000130373
Gene: ENSMUSG00000091805
AA Change: I576N

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	467	6e-33	PFAM
Pfam:NCD3G	510	563	9.2e-22	PFAM
Pfam:7tm_3	593	831	2.2e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 24 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrb1	T	C	15: 74,420,206 (GRCm39)		probably benign	Het
Asb1	G	A	1: 91,480,008 (GRCm39)	V236I	probably damaging	Het
Bod1l	G	A	5: 41,974,304 (GRCm39)	R2337C	probably benign	Het
Fermt3	A	T	19: 6,980,834 (GRCm39)		probably null	Het
Foxred2	T	C	15: 77,836,546 (GRCm39)	D323G	probably damaging	Het
Fry	A	G	5: 150,269,116 (GRCm39)		probably benign	Het
Galnt11	T	A	5: 25,452,513 (GRCm39)	Y8*	probably null	Het
Gm42688	T	A	6: 83,080,001 (GRCm39)	S275T	possibly damaging	Het
Grip2	C	T	6: 91,741,724 (GRCm39)	G934R	probably damaging	Het
Igkv1-122	G	T	6: 67,994,456 (GRCm39)	V115F	possibly damaging	Het
Iglon5	C	T	7: 43,125,953 (GRCm39)		probably benign	Het
Nbl1	G	T	4: 138,810,921 (GRCm39)		probably benign	Het
Nup107	A	G	10: 117,593,179 (GRCm39)	V833A	probably benign	Het
Or4k41	T	C	2: 111,279,875 (GRCm39)	L130P	probably damaging	Het
Psg18	T	C	7: 18,087,476 (GRCm39)	N61D	probably benign	Het
Rfng	A	G	11: 120,674,569 (GRCm39)	M104T	probably benign	Het
Scn10a	A	G	9: 119,456,150 (GRCm39)	F1224S	probably damaging	Het
Strn4	C	T	7: 16,572,227 (GRCm39)	P647S	probably damaging	Het
Tbc1d2	A	G	4: 46,616,306 (GRCm39)	V474A	probably damaging	Het
Trav13n-4	A	T	14: 53,601,470 (GRCm39)	T80S	probably benign	Het
Trrap	A	G	5: 144,770,150 (GRCm39)	E2757G	probably damaging	Het
Vmn1r43	G	T	6: 89,847,294 (GRCm39)	T64N	probably damaging	Het
Vmn2r65	A	T	7: 84,589,507 (GRCm39)	I803N	probably damaging	Het
Zfp341	T	C	2: 154,470,847 (GRCm39)	V288A	probably damaging	Het

Other mutations in Vmn2r108

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00903:Vmn2r108	APN	17	20,682,774 (GRCm39)	missense	probably damaging	0.98
IGL01143:Vmn2r108	APN	17	20,682,727 (GRCm39)	missense	possibly damaging	0.82
IGL01311:Vmn2r108	APN	17	20,682,939 (GRCm39)	nonsense	probably null
IGL01411:Vmn2r108	APN	17	20,691,282 (GRCm39)	missense	probably benign	0.01
IGL01414:Vmn2r108	APN	17	20,691,942 (GRCm39)	missense	probably benign	0.00
IGL01536:Vmn2r108	APN	17	20,683,543 (GRCm39)	missense	probably damaging	1.00
IGL01769:Vmn2r108	APN	17	20,691,280 (GRCm39)	missense	probably benign	0.02
IGL02022:Vmn2r108	APN	17	20,691,987 (GRCm39)	missense	possibly damaging	0.77
IGL02041:Vmn2r108	APN	17	20,683,398 (GRCm39)	missense	probably damaging	1.00
IGL02049:Vmn2r108	APN	17	20,691,608 (GRCm39)	missense	probably benign	0.00
IGL02344:Vmn2r108	APN	17	20,689,405 (GRCm39)	missense	probably damaging	1.00
IGL02939:Vmn2r108	APN	17	20,691,545 (GRCm39)	missense	probably benign	0.05
IGL03202:Vmn2r108	APN	17	20,691,319 (GRCm39)	nonsense	probably null
PIT4498001:Vmn2r108	UTSW	17	20,683,279 (GRCm39)	missense	probably damaging	1.00
R0112:Vmn2r108	UTSW	17	20,691,897 (GRCm39)	missense	probably benign	0.07
R0505:Vmn2r108	UTSW	17	20,683,096 (GRCm39)	missense	possibly damaging	0.77
R0833:Vmn2r108	UTSW	17	20,691,721 (GRCm39)	missense	probably benign
R0836:Vmn2r108	UTSW	17	20,691,721 (GRCm39)	missense	probably benign
R0943:Vmn2r108	UTSW	17	20,691,397 (GRCm39)	nonsense	probably null
R1411:Vmn2r108	UTSW	17	20,683,107 (GRCm39)	missense	probably damaging	0.98
R1442:Vmn2r108	UTSW	17	20,692,623 (GRCm39)	nonsense	probably null
R1587:Vmn2r108	UTSW	17	20,692,383 (GRCm39)	missense	probably damaging	1.00
R1751:Vmn2r108	UTSW	17	20,682,786 (GRCm39)	missense	probably damaging	1.00
R1773:Vmn2r108	UTSW	17	20,689,335 (GRCm39)	missense	probably damaging	1.00
R2021:Vmn2r108	UTSW	17	20,691,252 (GRCm39)	missense	probably benign	0.00
R2159:Vmn2r108	UTSW	17	20,689,363 (GRCm39)	missense	probably benign	0.41
R2224:Vmn2r108	UTSW	17	20,701,295 (GRCm39)	nonsense	probably null
R2226:Vmn2r108	UTSW	17	20,701,295 (GRCm39)	nonsense	probably null
R2517:Vmn2r108	UTSW	17	20,692,577 (GRCm39)	missense	probably damaging	1.00
R3710:Vmn2r108	UTSW	17	20,682,932 (GRCm39)	missense	probably benign
R4470:Vmn2r108	UTSW	17	20,682,990 (GRCm39)	missense	probably damaging	1.00
R4686:Vmn2r108	UTSW	17	20,691,636 (GRCm39)	missense	probably damaging	0.99
R4729:Vmn2r108	UTSW	17	20,692,632 (GRCm39)	missense	probably damaging	0.99
R4799:Vmn2r108	UTSW	17	20,682,891 (GRCm39)	missense	probably damaging	1.00
R4993:Vmn2r108	UTSW	17	20,701,449 (GRCm39)	missense	probably benign	0.04
R5088:Vmn2r108	UTSW	17	20,690,454 (GRCm39)	missense	possibly damaging	0.46
R5213:Vmn2r108	UTSW	17	20,691,755 (GRCm39)	missense	probably benign	0.00
R5289:Vmn2r108	UTSW	17	20,691,866 (GRCm39)	missense	probably damaging	1.00
R5290:Vmn2r108	UTSW	17	20,691,665 (GRCm39)	missense	probably benign	0.00
R5713:Vmn2r108	UTSW	17	20,691,290 (GRCm39)	missense	probably damaging	1.00
R5753:Vmn2r108	UTSW	17	20,683,179 (GRCm39)	missense	probably damaging	0.99
R5792:Vmn2r108	UTSW	17	20,683,398 (GRCm39)	missense	probably damaging	0.99
R5798:Vmn2r108	UTSW	17	20,692,545 (GRCm39)	missense	probably benign	0.39
R5897:Vmn2r108	UTSW	17	20,691,580 (GRCm39)	missense	probably benign	0.01
R6018:Vmn2r108	UTSW	17	20,683,268 (GRCm39)	missense	possibly damaging	0.83
R6093:Vmn2r108	UTSW	17	20,701,402 (GRCm39)	missense	probably benign	0.00
R6156:Vmn2r108	UTSW	17	20,692,447 (GRCm39)	missense	probably benign	0.03
R6199:Vmn2r108	UTSW	17	20,682,644 (GRCm39)	missense	probably benign	0.01
R6259:Vmn2r108	UTSW	17	20,683,371 (GRCm39)	missense	possibly damaging	0.95
R6309:Vmn2r108	UTSW	17	20,691,660 (GRCm39)	missense	probably damaging	0.98
R6324:Vmn2r108	UTSW	17	20,691,977 (GRCm39)	nonsense	probably null
R6364:Vmn2r108	UTSW	17	20,691,260 (GRCm39)	missense	probably benign	0.00
R6446:Vmn2r108	UTSW	17	20,692,609 (GRCm39)	nonsense	probably null
R6541:Vmn2r108	UTSW	17	20,701,480 (GRCm39)	missense	probably benign	0.02
R7025:Vmn2r108	UTSW	17	20,691,345 (GRCm39)	missense	possibly damaging	0.67
R7063:Vmn2r108	UTSW	17	20,701,410 (GRCm39)	missense	probably damaging	1.00
R7092:Vmn2r108	UTSW	17	20,701,338 (GRCm39)	missense	probably benign	0.10
R7096:Vmn2r108	UTSW	17	20,682,762 (GRCm39)	missense	probably damaging	1.00
R7203:Vmn2r108	UTSW	17	20,683,038 (GRCm39)	missense	probably benign	0.12
R7458:Vmn2r108	UTSW	17	20,692,532 (GRCm39)	missense	probably benign	0.17
R7619:Vmn2r108	UTSW	17	20,692,457 (GRCm39)	missense	probably benign	0.02
R7841:Vmn2r108	UTSW	17	20,690,305 (GRCm39)	critical splice donor site	probably null
R7944:Vmn2r108	UTSW	17	20,691,890 (GRCm39)	missense	probably damaging	0.99
R8048:Vmn2r108	UTSW	17	20,691,762 (GRCm39)	missense	probably benign	0.29
R8213:Vmn2r108	UTSW	17	20,690,350 (GRCm39)	missense	probably benign	0.03
R8218:Vmn2r108	UTSW	17	20,683,465 (GRCm39)	missense	probably damaging	1.00
R8507:Vmn2r108	UTSW	17	20,683,195 (GRCm39)	nonsense	probably null
R8708:Vmn2r108	UTSW	17	20,682,687 (GRCm39)	missense	probably damaging	0.98
R8845:Vmn2r108	UTSW	17	20,691,361 (GRCm39)	missense	probably benign	0.03
R9030:Vmn2r108	UTSW	17	20,690,312 (GRCm39)	missense	probably benign	0.01
R9226:Vmn2r108	UTSW	17	20,691,330 (GRCm39)	missense	probably benign
R9278:Vmn2r108	UTSW	17	20,692,561 (GRCm39)	missense	probably benign	0.11
X0022:Vmn2r108	UTSW	17	20,691,371 (GRCm39)	missense	probably damaging	1.00
Z1088:Vmn2r108	UTSW	17	20,691,375 (GRCm39)	missense	probably benign	0.01
Z1177:Vmn2r108	UTSW	17	20,691,219 (GRCm39)	missense	probably damaging	0.99

Posted On

2014-02-04