Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01751:Igdcc4'

153128

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Igdcc4

Ensembl Gene

ENSMUSG00000032816

Gene Name

immunoglobulin superfamily, DCC subclass, member 4

Synonyms

WI-18508, Nope, 9330155G14Rik, WI-16786

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.294) question?

Stock #

IGL01751

Quality Score

Status

Chromosome

Chromosomal Location

65008768-65045222 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 65039014 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Isoleucine at position 887 (N887I)

Ref Sequence

ENSEMBL: ENSMUSP00000045387 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035499] [ENSMUST00000077696] [ENSMUST00000166273] [ENSMUST00000213533]

AlphaFold

Q9EQS9

Predicted Effect

probably damaging
Transcript: ENSMUST00000035499
AA Change: N887I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000045387
Gene: ENSMUSG00000032816
AA Change: N887I

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
IG	40	139	5e0	SMART
IGc2	154	218	1.3e-11	SMART
IGc2	255	318	1.13e-11	SMART
low complexity region	322	335	N/A	INTRINSIC
IGc2	346	411	1.34e-13	SMART
FN3	428	511	3.58e-12	SMART
FN3	526	610	9.54e-8	SMART
FN3	630	726	7.34e-9	SMART
FN3	750	832	1.05e-9	SMART
FN3	848	932	2.14e-10	SMART
low complexity region	958	978	N/A	INTRINSIC
low complexity region	1085	1100	N/A	INTRINSIC
low complexity region	1154	1168	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000077696
AA Change: N933I

PolyPhen 2 Score 0.861 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000076878
Gene: ENSMUSG00000032816
AA Change: N933I

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
IG	40	139	5e0	SMART
IGc2	154	218	1.3e-11	SMART
IGc2	255	458	7.02e-8	SMART
FN3	475	558	3.58e-12	SMART
FN3	573	656	1.1e-7	SMART
FN3	676	772	7.34e-9	SMART
FN3	796	878	1.05e-9	SMART
FN3	894	978	2.14e-10	SMART
low complexity region	1004	1024	N/A	INTRINSIC
low complexity region	1131	1146	N/A	INTRINSIC
low complexity region	1200	1214	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000166273

SMART Domains

Protein: ENSMUSP00000132576
Gene: ENSMUSG00000032816

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Blast:IG	40	83	3e-22	BLAST
low complexity region	142	156	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000213423

Predicted Effect

probably benign
Transcript: ENSMUST00000213533
AA Change: N886I

PolyPhen 2 Score 0.264 (Sensitivity: 0.91; Specificity: 0.88)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214978

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700018F24Rik	A	G	5: 144,979,981 (GRCm39)		probably null	Het
Abtb3	C	A	10: 85,490,366 (GRCm39)	Q1011K	probably damaging	Het
Aoc1l2	A	T	6: 48,907,522 (GRCm39)	H174L	possibly damaging	Het
Auts2	G	T	5: 131,501,198 (GRCm39)	Q72K	probably damaging	Het
Ccdc7b	A	T	8: 129,863,049 (GRCm39)		probably benign	Het
Frem3	A	G	8: 81,342,372 (GRCm39)	E1555G	probably benign	Het
Gm5263	T	G	1: 146,296,302 (GRCm39)		noncoding transcript	Het
Gm5828	A	G	1: 16,840,208 (GRCm39)		noncoding transcript	Het
Gm6605	T	C	7: 38,147,630 (GRCm39)		noncoding transcript	Het
Gvin3	T	A	7: 106,201,516 (GRCm39)	N576I	possibly damaging	Het
Hps3	T	C	3: 20,065,130 (GRCm39)	D638G	probably damaging	Het
Itpkc	G	A	7: 26,912,491 (GRCm39)		probably benign	Het
Mfge8	A	G	7: 78,786,403 (GRCm39)		probably null	Het
Mrc2	G	T	11: 105,216,560 (GRCm39)	L116F	probably benign	Het
Necab1	T	C	4: 14,978,171 (GRCm39)	D226G	probably damaging	Het
Neurod2	T	C	11: 98,218,201 (GRCm39)	E321G	possibly damaging	Het
Obp2b	G	T	2: 25,627,760 (GRCm39)	V59L	possibly damaging	Het
Olr1	T	C	6: 129,465,811 (GRCm39)	N65S	possibly damaging	Het
Or14c39	A	T	7: 86,343,997 (GRCm39)	Q111L	probably benign	Het
Or2n1	G	T	17: 38,486,577 (GRCm39)	V201L	probably benign	Het
Or5d43	A	T	2: 88,104,977 (GRCm39)	C139S	possibly damaging	Het
Or8b48	C	T	9: 38,492,809 (GRCm39)	P79S	probably damaging	Het
Rock1	A	G	18: 10,079,113 (GRCm39)		probably null	Het
Scn3a	T	A	2: 65,291,596 (GRCm39)	M1717L	possibly damaging	Het
Smg7	T	C	1: 152,719,812 (GRCm39)	D903G	possibly damaging	Het
Tlr1	A	T	5: 65,083,290 (GRCm39)	L429*	probably null	Het
Ttll9	A	T	2: 152,825,025 (GRCm39)	N68I	probably damaging	Het
Ttn	A	G	2: 76,567,943 (GRCm39)	V25904A	possibly damaging	Het
Uaca	G	A	9: 60,777,139 (GRCm39)	V507M	probably damaging	Het
Vmn1r195	G	T	13: 22,463,421 (GRCm39)	C297F	probably benign	Het
Zdhhc2	G	A	8: 40,926,042 (GRCm39)	A346T	probably benign	Het

Other mutations in Igdcc4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01152:Igdcc4	APN	9	65,042,446 (GRCm39)	missense	probably damaging	1.00
IGL01285:Igdcc4	APN	9	65,031,273 (GRCm39)	missense	probably damaging	1.00
IGL01412:Igdcc4	APN	9	65,021,731 (GRCm39)	splice site	probably benign
IGL01485:Igdcc4	APN	9	65,029,889 (GRCm39)	missense	probably benign	0.02
IGL01552:Igdcc4	APN	9	65,029,784 (GRCm39)	intron	probably benign
IGL01651:Igdcc4	APN	9	65,031,394 (GRCm39)	missense	possibly damaging	0.63
IGL02164:Igdcc4	APN	9	65,032,064 (GRCm39)	splice site	probably benign
IGL02468:Igdcc4	APN	9	65,034,114 (GRCm39)	missense	probably damaging	1.00
IGL02616:Igdcc4	APN	9	65,040,360 (GRCm39)	missense	probably damaging	1.00
IGL02685:Igdcc4	APN	9	65,041,107 (GRCm39)	missense	possibly damaging	0.81
IGL02734:Igdcc4	APN	9	65,038,738 (GRCm39)	missense	possibly damaging	0.47
IGL02893:Igdcc4	APN	9	65,040,353 (GRCm39)	missense	probably damaging	1.00
R0006:Igdcc4	UTSW	9	65,042,382 (GRCm39)	splice site	probably benign
R0583:Igdcc4	UTSW	9	65,029,095 (GRCm39)	missense	possibly damaging	0.85
R0939:Igdcc4	UTSW	9	65,038,755 (GRCm39)	critical splice donor site	probably null
R1075:Igdcc4	UTSW	9	65,038,932 (GRCm39)	missense	possibly damaging	0.90
R1110:Igdcc4	UTSW	9	65,034,208 (GRCm39)	missense	possibly damaging	0.91
R1183:Igdcc4	UTSW	9	65,029,182 (GRCm39)	missense	possibly damaging	0.91
R1318:Igdcc4	UTSW	9	65,040,972 (GRCm39)	missense	probably damaging	1.00
R1507:Igdcc4	UTSW	9	65,041,026 (GRCm39)	missense	probably damaging	1.00
R1548:Igdcc4	UTSW	9	65,042,509 (GRCm39)	missense	probably benign	0.08
R1640:Igdcc4	UTSW	9	65,030,077 (GRCm39)	missense	probably damaging	1.00
R1681:Igdcc4	UTSW	9	65,036,077 (GRCm39)	missense	probably damaging	1.00
R1687:Igdcc4	UTSW	9	65,038,945 (GRCm39)	missense	probably damaging	1.00
R1716:Igdcc4	UTSW	9	65,034,179 (GRCm39)	missense	probably damaging	1.00
R1964:Igdcc4	UTSW	9	65,030,051 (GRCm39)	missense	probably benign
R1996:Igdcc4	UTSW	9	65,029,101 (GRCm39)	missense	probably damaging	1.00
R2150:Igdcc4	UTSW	9	65,032,617 (GRCm39)	missense	possibly damaging	0.92
R2278:Igdcc4	UTSW	9	65,038,025 (GRCm39)	missense	probably damaging	1.00
R3085:Igdcc4	UTSW	9	65,039,340 (GRCm39)	missense	probably damaging	1.00
R4011:Igdcc4	UTSW	9	65,042,761 (GRCm39)	missense	probably benign
R4077:Igdcc4	UTSW	9	65,039,047 (GRCm39)	missense	probably damaging	1.00
R4191:Igdcc4	UTSW	9	65,031,433 (GRCm39)	missense	probably benign	0.13
R4293:Igdcc4	UTSW	9	65,031,892 (GRCm39)	critical splice acceptor site	probably null
R4589:Igdcc4	UTSW	9	65,037,910 (GRCm39)	missense	probably damaging	1.00
R4931:Igdcc4	UTSW	9	65,031,297 (GRCm39)	missense	possibly damaging	0.66
R5093:Igdcc4	UTSW	9	65,030,039 (GRCm39)	missense	possibly damaging	0.51
R5106:Igdcc4	UTSW	9	65,031,983 (GRCm39)	missense	probably damaging	1.00
R5546:Igdcc4	UTSW	9	65,036,077 (GRCm39)	missense	probably damaging	1.00
R5634:Igdcc4	UTSW	9	65,041,828 (GRCm39)	missense	probably benign	0.18
R5810:Igdcc4	UTSW	9	65,035,977 (GRCm39)	missense	probably damaging	1.00
R6395:Igdcc4	UTSW	9	65,042,400 (GRCm39)	missense	probably damaging	1.00
R6475:Igdcc4	UTSW	9	65,027,603 (GRCm39)	missense	probably damaging	1.00
R6776:Igdcc4	UTSW	9	65,042,700 (GRCm39)	missense	probably benign	0.02
R6828:Igdcc4	UTSW	9	65,029,979 (GRCm39)	missense	probably benign
R6914:Igdcc4	UTSW	9	65,027,550 (GRCm39)	missense	probably benign	0.00
R6942:Igdcc4	UTSW	9	65,027,550 (GRCm39)	missense	probably benign	0.00
R7072:Igdcc4	UTSW	9	65,038,013 (GRCm39)	missense	probably damaging	1.00
R7234:Igdcc4	UTSW	9	65,042,750 (GRCm39)	nonsense	probably null
R7448:Igdcc4	UTSW	9	65,031,276 (GRCm39)	missense	possibly damaging	0.52
R7562:Igdcc4	UTSW	9	65,031,306 (GRCm39)	missense	probably damaging	1.00
R7607:Igdcc4	UTSW	9	65,041,040 (GRCm39)	missense	possibly damaging	0.85
R7734:Igdcc4	UTSW	9	65,039,035 (GRCm39)	missense	probably damaging	0.99
R7807:Igdcc4	UTSW	9	65,041,077 (GRCm39)	missense	probably benign	0.00
R7852:Igdcc4	UTSW	9	65,027,540 (GRCm39)	missense	probably benign	0.04
R7904:Igdcc4	UTSW	9	65,041,801 (GRCm39)	missense	probably benign	0.00
R8133:Igdcc4	UTSW	9	65,039,023 (GRCm39)	missense	possibly damaging	0.54
R8147:Igdcc4	UTSW	9	65,031,253 (GRCm39)	missense	probably benign	0.42
R8230:Igdcc4	UTSW	9	65,030,020 (GRCm39)	missense	probably damaging	1.00
R8822:Igdcc4	UTSW	9	65,031,298 (GRCm39)	missense	possibly damaging	0.50
R8846:Igdcc4	UTSW	9	65,037,898 (GRCm39)	missense	probably benign	0.12
R9250:Igdcc4	UTSW	9	65,038,932 (GRCm39)	missense	possibly damaging	0.90
R9613:Igdcc4	UTSW	9	65,027,522 (GRCm39)	missense	possibly damaging	0.87
R9681:Igdcc4	UTSW	9	65,041,858 (GRCm39)	missense	possibly damaging	0.89

Posted On

2014-02-04