Incidental Mutation 'IGL01755:Or5w8'
ID 153190
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5w8
Ensembl Gene ENSMUSG00000047039
Gene Name olfactory receptor family 5 subfamily W member 8
Synonyms MOR177-9, Olfr1151, GA_x6K02T2Q125-49358694-49359620
Accession Numbers
Essential gene? Probably non essential (E-score: 0.158) question?
Stock # IGL01755
Quality Score
Status
Chromosome 2
Chromosomal Location 87687521-87688447 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 87687854 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 112 (C112S)
Ref Sequence ENSEMBL: ENSMUSP00000151107 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061081] [ENSMUST00000217376]
AlphaFold Q8VFQ8
Predicted Effect possibly damaging
Transcript: ENSMUST00000061081
AA Change: C112S

PolyPhen 2 Score 0.595 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000055394
Gene: ENSMUSG00000047039
AA Change: C112S

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.6e-45 PFAM
Pfam:7tm_1 41 290 1.7e-15 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000217376
AA Change: C112S

PolyPhen 2 Score 0.595 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atf6 A G 1: 170,616,180 (GRCm39) I520T possibly damaging Het
Azgp1 A T 5: 137,988,109 (GRCm39) K297M possibly damaging Het
Cyp2e1 A G 7: 140,354,469 (GRCm39) probably null Het
Dapk1 C A 13: 60,908,989 (GRCm39) L1201M probably damaging Het
Dapk1 T A 13: 60,908,990 (GRCm39) L1201Q possibly damaging Het
Insrr A T 3: 87,721,493 (GRCm39) D1133V probably damaging Het
Kcnc4 T C 3: 107,355,491 (GRCm39) N319S probably damaging Het
Kctd1 A G 18: 15,195,694 (GRCm39) C310R possibly damaging Het
Nefl A G 14: 68,323,526 (GRCm39) D384G probably damaging Het
Nfatc3 A G 8: 106,854,553 (GRCm39) N1029S probably benign Het
Nup107 T C 10: 117,610,398 (GRCm39) Y348C probably damaging Het
Or5b117 T C 19: 13,431,179 (GRCm39) K234R probably damaging Het
Phf8-ps T A 17: 33,285,951 (GRCm39) N284Y probably damaging Het
Phldb2 T C 16: 45,645,945 (GRCm39) E212G probably damaging Het
Pirb A T 7: 3,720,169 (GRCm39) N401K probably benign Het
Plcg2 T C 8: 118,347,980 (GRCm39) F1183S possibly damaging Het
Plekhf2 A T 4: 10,991,308 (GRCm39) N11K probably damaging Het
Slc7a11 A G 3: 50,378,516 (GRCm39) Y241H probably benign Het
Sltm T G 9: 70,491,204 (GRCm39) probably null Het
Taf4b A G 18: 15,031,042 (GRCm39) T809A probably benign Het
Taf4b C A 18: 15,031,043 (GRCm39) T809N probably benign Het
Tesk1 T C 4: 43,445,820 (GRCm39) probably null Het
Tspan8 C T 10: 115,671,203 (GRCm39) T120M probably damaging Het
Ttn T G 2: 76,551,727 (GRCm39) D31275A probably damaging Het
Vcl C A 14: 21,046,038 (GRCm39) Q334K probably damaging Het
Zfp94 G A 7: 24,010,906 (GRCm39) probably benign Het
Zkscan17 A G 11: 59,378,241 (GRCm39) F314S probably damaging Het
Other mutations in Or5w8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02314:Or5w8 APN 2 87,688,400 (GRCm39) missense probably damaging 1.00
R0127:Or5w8 UTSW 2 87,687,827 (GRCm39) missense probably benign
R0233:Or5w8 UTSW 2 87,688,096 (GRCm39) missense probably benign 0.19
R0233:Or5w8 UTSW 2 87,688,096 (GRCm39) missense probably benign 0.19
R0398:Or5w8 UTSW 2 87,688,401 (GRCm39) missense probably damaging 1.00
R1079:Or5w8 UTSW 2 87,687,699 (GRCm39) missense probably damaging 1.00
R1598:Or5w8 UTSW 2 87,688,095 (GRCm39) missense probably benign 0.01
R1965:Or5w8 UTSW 2 87,687,759 (GRCm39) missense probably benign 0.44
R3409:Or5w8 UTSW 2 87,688,005 (GRCm39) nonsense probably null
R4824:Or5w8 UTSW 2 87,687,621 (GRCm39) missense probably benign 0.24
R4962:Or5w8 UTSW 2 87,687,632 (GRCm39) missense probably benign 0.02
R4986:Or5w8 UTSW 2 87,687,858 (GRCm39) missense probably damaging 0.97
R5324:Or5w8 UTSW 2 87,688,040 (GRCm39) missense probably damaging 1.00
R5934:Or5w8 UTSW 2 87,687,585 (GRCm39) missense probably benign
R6335:Or5w8 UTSW 2 87,687,811 (GRCm39) nonsense probably null
R6389:Or5w8 UTSW 2 87,688,367 (GRCm39) missense probably damaging 1.00
R6958:Or5w8 UTSW 2 87,688,295 (GRCm39) missense probably damaging 1.00
R7329:Or5w8 UTSW 2 87,687,585 (GRCm39) missense probably benign
R8228:Or5w8 UTSW 2 87,688,284 (GRCm39) missense probably benign 0.12
R8506:Or5w8 UTSW 2 87,688,181 (GRCm39) missense probably damaging 1.00
R8726:Or5w8 UTSW 2 87,688,161 (GRCm39) missense probably benign 0.14
R8845:Or5w8 UTSW 2 87,687,545 (GRCm39) missense probably benign 0.00
R9548:Or5w8 UTSW 2 87,688,040 (GRCm39) missense probably damaging 1.00
Z1177:Or5w8 UTSW 2 87,687,768 (GRCm39) missense probably benign 0.13
Posted On 2014-02-04