Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01757:Ifna15'

153205

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifna15

Ensembl Gene

ENSMUSG00000096011

Gene Name

interferon alpha 15

Synonyms

Gm12597, Ifnaa

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.062) question?

Stock #

IGL01757

Quality Score

Status

Chromosome

Chromosomal Location

88475910-88476482 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 88476322 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Arginine at position 54 (K54R)

Ref Sequence

ENSEMBL: ENSMUSP00000099873 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000102809]

AlphaFold

Q61718

Predicted Effect

possibly damaging
Transcript: ENSMUST00000102809
AA Change: K54R

PolyPhen 2 Score 0.794 (Sensitivity: 0.85; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000099873
Gene: ENSMUSG00000096011
AA Change: K54R

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
IFabd	58	175	2.97e-68	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc6	T	C	7: 45,639,705 (GRCm39)		probably benign	Het
Adamts9	T	C	6: 92,773,140 (GRCm39)	Y1789C	probably damaging	Het
Cdcp1	A	T	9: 123,009,066 (GRCm39)	Y537*	probably null	Het
Chic2	T	C	5: 75,167,428 (GRCm39)		probably benign	Het
Cpa5	G	A	6: 30,625,926 (GRCm39)		probably benign	Het
Csgalnact2	T	C	6: 118,106,307 (GRCm39)	R4G	probably damaging	Het
Dnah10	T	A	5: 124,845,991 (GRCm39)	V1510D	probably benign	Het
Dnm2	T	A	9: 21,376,915 (GRCm39)	F91L	probably damaging	Het
Eif2b1	T	C	5: 124,711,203 (GRCm39)	K189E	probably benign	Het
Fgf17	A	T	14: 70,874,420 (GRCm39)	L123Q	probably damaging	Het
Isg15	A	G	4: 156,284,301 (GRCm39)	C76R	probably damaging	Het
Ldb2	A	T	5: 44,699,209 (GRCm39)		probably benign	Het
Lig4	A	G	8: 10,021,185 (GRCm39)	I865T	probably benign	Het
Lrrc46	T	C	11: 96,926,701 (GRCm39)	Y154C	probably damaging	Het
Lrrc8a	G	A	2: 30,145,537 (GRCm39)	R117H	possibly damaging	Het
Mrpl2	A	G	17: 46,959,183 (GRCm39)	I96V	probably damaging	Het
Mtif2	G	A	11: 29,491,337 (GRCm39)		probably benign	Het
Or2n1	G	T	17: 38,486,577 (GRCm39)	V201L	probably benign	Het
Ptpn23	G	A	9: 110,220,704 (GRCm39)	R269W	probably damaging	Het
Senp2	T	C	16: 21,828,414 (GRCm39)	V8A	probably benign	Het
Slf1	T	C	13: 77,232,559 (GRCm39)	D515G	probably benign	Het
Spc25	G	A	2: 69,032,952 (GRCm39)	Q58*	probably null	Het
Sult2a5	T	C	7: 13,399,079 (GRCm39)	S229P	probably damaging	Het
Tfap2d	A	G	1: 19,174,804 (GRCm39)	T86A	probably benign	Het
Trp53bp1	A	G	2: 121,041,785 (GRCm39)	V1257A	probably damaging	Het
Wdr6	A	G	9: 108,453,427 (GRCm39)	V152A	possibly damaging	Het
Zdhhc7	A	G	8: 120,814,662 (GRCm39)	V49A	probably benign	Het
Zfp648	T	C	1: 154,080,671 (GRCm39)	S277P	probably damaging	Het

Other mutations in Ifna15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01575:Ifna15	APN	4	88,476,044 (GRCm39)	missense	probably damaging	1.00
IGL01824:Ifna15	APN	4	88,476,020 (GRCm39)	missense	probably benign	0.00
R3853:Ifna15	UTSW	4	88,476,046 (GRCm39)	missense	probably damaging	1.00
R4356:Ifna15	UTSW	4	88,476,079 (GRCm39)	missense	probably benign	0.09
R4357:Ifna15	UTSW	4	88,476,079 (GRCm39)	missense	probably benign	0.09
R4358:Ifna15	UTSW	4	88,476,079 (GRCm39)	missense	probably benign	0.09
R4359:Ifna15	UTSW	4	88,476,079 (GRCm39)	missense	probably benign	0.09
R5038:Ifna15	UTSW	4	88,476,266 (GRCm39)	missense	probably benign	0.03
R5372:Ifna15	UTSW	4	88,476,338 (GRCm39)	missense	probably damaging	0.97
R6036:Ifna15	UTSW	4	88,476,310 (GRCm39)	missense	possibly damaging	0.65
R6036:Ifna15	UTSW	4	88,476,310 (GRCm39)	missense	possibly damaging	0.65
R7347:Ifna15	UTSW	4	88,476,220 (GRCm39)	missense	probably damaging	1.00
R8097:Ifna15	UTSW	4	88,475,938 (GRCm39)	missense	probably benign	0.01
R8132:Ifna15	UTSW	4	88,475,920 (GRCm39)	missense	possibly damaging	0.60
R8824:Ifna15	UTSW	4	88,475,998 (GRCm39)	missense	probably damaging	1.00
R9349:Ifna15	UTSW	4	88,476,283 (GRCm39)	missense	probably benign	0.10

Posted On

2014-02-04