Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01757:Zdhhc7'

153215

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zdhhc7

Ensembl Gene

ENSMUSG00000031823

Gene Name

zinc finger, DHHC domain containing 7

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

IGL01757

Quality Score

Status

Chromosome

Chromosomal Location

120080890-120101482 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 120087923 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 49 (V49A)

Ref Sequence

ENSEMBL: ENSMUSP00000034280 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000034280] [ENSMUST00000127664]

AlphaFold

Q91WU6

Predicted Effect

probably benign
Transcript: ENSMUST00000034280
AA Change: V49A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000034280
Gene: ENSMUSG00000031823
AA Change: V49A

Domain	Start	End	E-Value	Type
low complexity region	25	31	N/A	INTRINSIC
transmembrane domain	39	61	N/A	INTRINSIC
transmembrane domain	76	98	N/A	INTRINSIC
Pfam:zf-DHHC	129	258	9.8e-38	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000124044

Predicted Effect

probably benign
Transcript: ENSMUST00000127664

SMART Domains

Protein: ENSMUSP00000118564
Gene: ENSMUSG00000092329

Domain	Start	End	E-Value	Type
Pfam:Glycos_transf_2	104	287	7.4e-31	PFAM
Pfam:Glyco_transf_7C	261	331	4.9e-8	PFAM
RICIN	406	531	9.28e-27	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141886

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000150444

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc6	T	C	7: 45,990,281		probably benign	Het
Adamts9	T	C	6: 92,796,159	Y1789C	probably damaging	Het
Cdcp1	A	T	9: 123,180,001	Y537*	probably null	Het
Chic2	T	C	5: 75,006,767		probably benign	Het
Cpa5	G	A	6: 30,625,927		probably benign	Het
Csgalnact2	T	C	6: 118,129,346	R4G	probably damaging	Het
Dnah10	T	A	5: 124,768,927	V1510D	probably benign	Het
Dnm2	T	A	9: 21,465,619	F91L	probably damaging	Het
Eif2b1	T	C	5: 124,573,140	K189E	probably benign	Het
Fgf17	A	T	14: 70,636,980	L123Q	probably damaging	Het
Ifna15	T	C	4: 88,558,085	K54R	possibly damaging	Het
Isg15	A	G	4: 156,199,844	C76R	probably damaging	Het
Ldb2	A	T	5: 44,541,867		probably benign	Het
Lig4	A	G	8: 9,971,185	I865T	probably benign	Het
Lrrc46	T	C	11: 97,035,875	Y154C	probably damaging	Het
Lrrc8a	G	A	2: 30,255,525	R117H	possibly damaging	Het
Mrpl2	A	G	17: 46,648,257	I96V	probably damaging	Het
Mtif2	G	A	11: 29,541,337		probably benign	Het
Olfr134	G	T	17: 38,175,686	V201L	probably benign	Het
Ptpn23	G	A	9: 110,391,636	R269W	probably damaging	Het
Senp2	T	C	16: 22,009,664	V8A	probably benign	Het
Slf1	T	C	13: 77,084,440	D515G	probably benign	Het
Spc25	G	A	2: 69,202,608	Q58*	probably null	Het
Sult2a5	T	C	7: 13,665,154	S229P	probably damaging	Het
Tfap2d	A	G	1: 19,104,580	T86A	probably benign	Het
Trp53bp1	A	G	2: 121,211,304	V1257A	probably damaging	Het
Wdr6	A	G	9: 108,576,228	V152A	possibly damaging	Het
Zfp648	T	C	1: 154,204,925	S277P	probably damaging	Het

Other mutations in Zdhhc7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01988:Zdhhc7	APN	8	120082590	missense	probably benign	0.00
IGL03407:Zdhhc7	APN	8	120085392	missense	probably damaging	0.98
R0362:Zdhhc7	UTSW	8	120086647	missense	probably null	0.32
R0588:Zdhhc7	UTSW	8	120083367	intron	probably benign
R0629:Zdhhc7	UTSW	8	120088046	missense	possibly damaging	0.60
R1224:Zdhhc7	UTSW	8	120082572	missense	probably benign
R1317:Zdhhc7	UTSW	8	120084900	missense	probably benign	0.04
R1796:Zdhhc7	UTSW	8	120085418	missense	probably benign	0.04
R5891:Zdhhc7	UTSW	8	120084900	missense	probably benign	0.04
R6495:Zdhhc7	UTSW	8	120086656	missense	probably benign	0.19
R6711:Zdhhc7	UTSW	8	120083327	missense	probably benign	0.04
R6833:Zdhhc7	UTSW	8	120084924	missense	probably damaging	1.00
R7083:Zdhhc7	UTSW	8	120085427	missense	probably damaging	1.00
R7743:Zdhhc7	UTSW	8	120086728	missense	possibly damaging	0.49
R9368:Zdhhc7	UTSW	8	120087755	missense	probably damaging	1.00
R9401:Zdhhc7	UTSW	8	120086686	missense	probably benign	0.44

Posted On

2014-02-04