Incidental Mutation 'IGL01757:Zdhhc7'
ID 153215
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zdhhc7
Ensembl Gene ENSMUSG00000031823
Gene Name zinc finger, DHHC domain containing 7
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.080) question?
Stock # IGL01757
Quality Score
Status
Chromosome 8
Chromosomal Location 120080890-120101482 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 120087923 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 49 (V49A)
Ref Sequence ENSEMBL: ENSMUSP00000034280 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034280] [ENSMUST00000127664]
AlphaFold Q91WU6
Predicted Effect probably benign
Transcript: ENSMUST00000034280
AA Change: V49A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000034280
Gene: ENSMUSG00000031823
AA Change: V49A

DomainStartEndE-ValueType
low complexity region 25 31 N/A INTRINSIC
transmembrane domain 39 61 N/A INTRINSIC
transmembrane domain 76 98 N/A INTRINSIC
Pfam:zf-DHHC 129 258 9.8e-38 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124044
Predicted Effect probably benign
Transcript: ENSMUST00000127664
SMART Domains Protein: ENSMUSP00000118564
Gene: ENSMUSG00000092329

DomainStartEndE-ValueType
Pfam:Glycos_transf_2 104 287 7.4e-31 PFAM
Pfam:Glyco_transf_7C 261 331 4.9e-8 PFAM
RICIN 406 531 9.28e-27 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141886
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150444
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 T C 7: 45,990,281 probably benign Het
Adamts9 T C 6: 92,796,159 Y1789C probably damaging Het
Cdcp1 A T 9: 123,180,001 Y537* probably null Het
Chic2 T C 5: 75,006,767 probably benign Het
Cpa5 G A 6: 30,625,927 probably benign Het
Csgalnact2 T C 6: 118,129,346 R4G probably damaging Het
Dnah10 T A 5: 124,768,927 V1510D probably benign Het
Dnm2 T A 9: 21,465,619 F91L probably damaging Het
Eif2b1 T C 5: 124,573,140 K189E probably benign Het
Fgf17 A T 14: 70,636,980 L123Q probably damaging Het
Ifna15 T C 4: 88,558,085 K54R possibly damaging Het
Isg15 A G 4: 156,199,844 C76R probably damaging Het
Ldb2 A T 5: 44,541,867 probably benign Het
Lig4 A G 8: 9,971,185 I865T probably benign Het
Lrrc46 T C 11: 97,035,875 Y154C probably damaging Het
Lrrc8a G A 2: 30,255,525 R117H possibly damaging Het
Mrpl2 A G 17: 46,648,257 I96V probably damaging Het
Mtif2 G A 11: 29,541,337 probably benign Het
Olfr134 G T 17: 38,175,686 V201L probably benign Het
Ptpn23 G A 9: 110,391,636 R269W probably damaging Het
Senp2 T C 16: 22,009,664 V8A probably benign Het
Slf1 T C 13: 77,084,440 D515G probably benign Het
Spc25 G A 2: 69,202,608 Q58* probably null Het
Sult2a5 T C 7: 13,665,154 S229P probably damaging Het
Tfap2d A G 1: 19,104,580 T86A probably benign Het
Trp53bp1 A G 2: 121,211,304 V1257A probably damaging Het
Wdr6 A G 9: 108,576,228 V152A possibly damaging Het
Zfp648 T C 1: 154,204,925 S277P probably damaging Het
Other mutations in Zdhhc7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01988:Zdhhc7 APN 8 120082590 missense probably benign 0.00
IGL03407:Zdhhc7 APN 8 120085392 missense probably damaging 0.98
R0362:Zdhhc7 UTSW 8 120086647 missense probably null 0.32
R0588:Zdhhc7 UTSW 8 120083367 intron probably benign
R0629:Zdhhc7 UTSW 8 120088046 missense possibly damaging 0.60
R1224:Zdhhc7 UTSW 8 120082572 missense probably benign
R1317:Zdhhc7 UTSW 8 120084900 missense probably benign 0.04
R1796:Zdhhc7 UTSW 8 120085418 missense probably benign 0.04
R5891:Zdhhc7 UTSW 8 120084900 missense probably benign 0.04
R6495:Zdhhc7 UTSW 8 120086656 missense probably benign 0.19
R6711:Zdhhc7 UTSW 8 120083327 missense probably benign 0.04
R6833:Zdhhc7 UTSW 8 120084924 missense probably damaging 1.00
R7083:Zdhhc7 UTSW 8 120085427 missense probably damaging 1.00
R7743:Zdhhc7 UTSW 8 120086728 missense possibly damaging 0.49
R9368:Zdhhc7 UTSW 8 120087755 missense probably damaging 1.00
R9401:Zdhhc7 UTSW 8 120086686 missense probably benign 0.44
Posted On 2014-02-04