Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01757:Zfp648'

153224

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp648

Ensembl Gene

ENSMUSG00000066797

Gene Name

zinc finger protein 648

Synonyms

LOC207678, Gm10178

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.076) question?

Stock #

IGL01757

Quality Score

Status

Chromosome

Chromosomal Location

154201187-154205689 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 154204925 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 277 (S277P)

Ref Sequence

ENSEMBL: ENSMUSP00000083370 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000086195]

AlphaFold

D3Z0W3

Predicted Effect

probably damaging
Transcript: ENSMUST00000086195
AA Change: S277P

PolyPhen 2 Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000083370
Gene: ENSMUSG00000066797
AA Change: S277P

Domain	Start	End	E-Value	Type
ZnF_C2H2	236	258	1.82e-3	SMART
ZnF_C2H2	264	286	1.28e-3	SMART
ZnF_C2H2	292	315	1.2e-3	SMART
ZnF_C2H2	321	343	1.95e-3	SMART
ZnF_C2H2	349	371	8.94e-3	SMART
ZnF_C2H2	377	399	8.34e-3	SMART
ZnF_C2H2	405	427	4.54e-4	SMART
ZnF_C2H2	433	455	4.47e-3	SMART
ZnF_C2H2	461	483	5.81e-2	SMART
ZnF_C2H2	489	511	1.2e-3	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc6	T	C	7: 45,990,281		probably benign	Het
Adamts9	T	C	6: 92,796,159	Y1789C	probably damaging	Het
Cdcp1	A	T	9: 123,180,001	Y537*	probably null	Het
Chic2	T	C	5: 75,006,767		probably benign	Het
Cpa5	G	A	6: 30,625,927		probably benign	Het
Csgalnact2	T	C	6: 118,129,346	R4G	probably damaging	Het
Dnah10	T	A	5: 124,768,927	V1510D	probably benign	Het
Dnm2	T	A	9: 21,465,619	F91L	probably damaging	Het
Eif2b1	T	C	5: 124,573,140	K189E	probably benign	Het
Fgf17	A	T	14: 70,636,980	L123Q	probably damaging	Het
Ifna15	T	C	4: 88,558,085	K54R	possibly damaging	Het
Isg15	A	G	4: 156,199,844	C76R	probably damaging	Het
Ldb2	A	T	5: 44,541,867		probably benign	Het
Lig4	A	G	8: 9,971,185	I865T	probably benign	Het
Lrrc46	T	C	11: 97,035,875	Y154C	probably damaging	Het
Lrrc8a	G	A	2: 30,255,525	R117H	possibly damaging	Het
Mrpl2	A	G	17: 46,648,257	I96V	probably damaging	Het
Mtif2	G	A	11: 29,541,337		probably benign	Het
Olfr134	G	T	17: 38,175,686	V201L	probably benign	Het
Ptpn23	G	A	9: 110,391,636	R269W	probably damaging	Het
Senp2	T	C	16: 22,009,664	V8A	probably benign	Het
Slf1	T	C	13: 77,084,440	D515G	probably benign	Het
Spc25	G	A	2: 69,202,608	Q58*	probably null	Het
Sult2a5	T	C	7: 13,665,154	S229P	probably damaging	Het
Tfap2d	A	G	1: 19,104,580	T86A	probably benign	Het
Trp53bp1	A	G	2: 121,211,304	V1257A	probably damaging	Het
Wdr6	A	G	9: 108,576,228	V152A	possibly damaging	Het
Zdhhc7	A	G	8: 120,087,923	V49A	probably benign	Het

Other mutations in Zfp648

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00585:Zfp648	APN	1	154204189	missense	possibly damaging	0.88
IGL01150:Zfp648	APN	1	154205364	missense	probably damaging	1.00
IGL01557:Zfp648	APN	1	154204680	missense	probably benign
IGL02247:Zfp648	APN	1	154204177	missense	probably benign	0.01
PIT4519001:Zfp648	UTSW	1	154204941	missense	probably damaging	0.98
R0001:Zfp648	UTSW	1	154205286	missense	probably damaging	1.00
R0256:Zfp648	UTSW	1	154205668	missense	probably benign	0.08
R0266:Zfp648	UTSW	1	154204886	missense	probably damaging	1.00
R0371:Zfp648	UTSW	1	154204667	missense	possibly damaging	0.66
R1498:Zfp648	UTSW	1	154205373	missense	probably damaging	1.00
R1562:Zfp648	UTSW	1	154204392	missense	probably benign
R1687:Zfp648	UTSW	1	154204242	missense	probably benign	0.15
R2128:Zfp648	UTSW	1	154204607	missense	probably benign
R2427:Zfp648	UTSW	1	154205073	missense	probably damaging	1.00
R2567:Zfp648	UTSW	1	154204949	missense	probably damaging	0.98
R2844:Zfp648	UTSW	1	154205135	nonsense	probably null
R3711:Zfp648	UTSW	1	154204558	missense	probably benign	0.30
R4491:Zfp648	UTSW	1	154205127	missense	probably damaging	1.00
R4693:Zfp648	UTSW	1	154204406	missense	probably benign	0.01
R5666:Zfp648	UTSW	1	154204217	missense	probably benign	0.00
R5670:Zfp648	UTSW	1	154204217	missense	probably benign	0.00
R7432:Zfp648	UTSW	1	154205037	missense	possibly damaging	0.84
R8069:Zfp648	UTSW	1	154204116	missense	probably benign	0.34
R8137:Zfp648	UTSW	1	154205364	missense	probably damaging	1.00
R8282:Zfp648	UTSW	1	154204789	missense	probably benign	0.25
R9023:Zfp648	UTSW	1	154205168	missense	probably damaging	0.98
R9489:Zfp648	UTSW	1	154204364	missense	probably benign	0.17
R9520:Zfp648	UTSW	1	154205475	missense	probably benign
R9605:Zfp648	UTSW	1	154204364	missense	probably benign	0.17
Z1088:Zfp648	UTSW	1	154204520	missense	probably benign	0.00

Posted On

2014-02-04