Incidental Mutation 'IGL01757:Cpa5'
ID 153227
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cpa5
Ensembl Gene ENSMUSG00000029788
Gene Name carboxypeptidase A5
Synonyms 4930430M09Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # IGL01757
Quality Score
Status
Chromosome 6
Chromosomal Location 30611009-30631744 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) G to A at 30625926 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000126436 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062758] [ENSMUST00000115138] [ENSMUST00000115139] [ENSMUST00000165949]
AlphaFold Q8R4H4
Predicted Effect probably benign
Transcript: ENSMUST00000062758
SMART Domains Protein: ENSMUSP00000057722
Gene: ENSMUSG00000029788

DomainStartEndE-ValueType
Pfam:Propep_M14 43 117 5.6e-23 PFAM
Zn_pept 139 419 4.83e-125 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115138
SMART Domains Protein: ENSMUSP00000110791
Gene: ENSMUSG00000029788

DomainStartEndE-ValueType
Pfam:Propep_M14 43 118 9.9e-26 PFAM
Zn_pept 139 395 4.62e-81 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115139
SMART Domains Protein: ENSMUSP00000110792
Gene: ENSMUSG00000029788

DomainStartEndE-ValueType
Pfam:Propep_M14 43 118 4.6e-25 PFAM
Zn_pept 139 419 4.83e-125 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000165949
SMART Domains Protein: ENSMUSP00000126436
Gene: ENSMUSG00000029788

DomainStartEndE-ValueType
Pfam:Propep_M14 43 118 6.4e-26 PFAM
Zn_pept 139 309 3.6e-19 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein undergoes proteolytic processing that removes the N-terminal activation peptide to generate a functional enzyme. This gene is expressed in mouse testes where the encoded protein is localized to the germ cells. This gene is located in a cluster of carboxypeptidase genes on chromosome 6. [provided by RefSeq, Jul 2016]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 T C 7: 45,639,705 (GRCm39) probably benign Het
Adamts9 T C 6: 92,773,140 (GRCm39) Y1789C probably damaging Het
Cdcp1 A T 9: 123,009,066 (GRCm39) Y537* probably null Het
Chic2 T C 5: 75,167,428 (GRCm39) probably benign Het
Csgalnact2 T C 6: 118,106,307 (GRCm39) R4G probably damaging Het
Dnah10 T A 5: 124,845,991 (GRCm39) V1510D probably benign Het
Dnm2 T A 9: 21,376,915 (GRCm39) F91L probably damaging Het
Eif2b1 T C 5: 124,711,203 (GRCm39) K189E probably benign Het
Fgf17 A T 14: 70,874,420 (GRCm39) L123Q probably damaging Het
Ifna15 T C 4: 88,476,322 (GRCm39) K54R possibly damaging Het
Isg15 A G 4: 156,284,301 (GRCm39) C76R probably damaging Het
Ldb2 A T 5: 44,699,209 (GRCm39) probably benign Het
Lig4 A G 8: 10,021,185 (GRCm39) I865T probably benign Het
Lrrc46 T C 11: 96,926,701 (GRCm39) Y154C probably damaging Het
Lrrc8a G A 2: 30,145,537 (GRCm39) R117H possibly damaging Het
Mrpl2 A G 17: 46,959,183 (GRCm39) I96V probably damaging Het
Mtif2 G A 11: 29,491,337 (GRCm39) probably benign Het
Or2n1 G T 17: 38,486,577 (GRCm39) V201L probably benign Het
Ptpn23 G A 9: 110,220,704 (GRCm39) R269W probably damaging Het
Senp2 T C 16: 21,828,414 (GRCm39) V8A probably benign Het
Slf1 T C 13: 77,232,559 (GRCm39) D515G probably benign Het
Spc25 G A 2: 69,032,952 (GRCm39) Q58* probably null Het
Sult2a5 T C 7: 13,399,079 (GRCm39) S229P probably damaging Het
Tfap2d A G 1: 19,174,804 (GRCm39) T86A probably benign Het
Trp53bp1 A G 2: 121,041,785 (GRCm39) V1257A probably damaging Het
Wdr6 A G 9: 108,453,427 (GRCm39) V152A possibly damaging Het
Zdhhc7 A G 8: 120,814,662 (GRCm39) V49A probably benign Het
Zfp648 T C 1: 154,080,671 (GRCm39) S277P probably damaging Het
Other mutations in Cpa5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02577:Cpa5 APN 6 30,626,807 (GRCm39) splice site probably benign
IGL03148:Cpa5 APN 6 30,630,436 (GRCm39) missense probably damaging 1.00
IGL03341:Cpa5 APN 6 30,626,290 (GRCm39) missense possibly damaging 0.57
R0836:Cpa5 UTSW 6 30,623,210 (GRCm39) missense probably damaging 1.00
R1437:Cpa5 UTSW 6 30,624,654 (GRCm39) missense probably damaging 1.00
R2146:Cpa5 UTSW 6 30,626,821 (GRCm39) missense probably damaging 1.00
R2285:Cpa5 UTSW 6 30,615,063 (GRCm39) missense probably benign 0.09
R2334:Cpa5 UTSW 6 30,624,605 (GRCm39) nonsense probably null
R4081:Cpa5 UTSW 6 30,631,228 (GRCm39) missense probably benign 0.02
R4454:Cpa5 UTSW 6 30,626,323 (GRCm39) missense possibly damaging 0.84
R4483:Cpa5 UTSW 6 30,624,625 (GRCm39) missense probably damaging 1.00
R4758:Cpa5 UTSW 6 30,615,159 (GRCm39) missense possibly damaging 0.67
R4771:Cpa5 UTSW 6 30,612,684 (GRCm39) nonsense probably null
R4953:Cpa5 UTSW 6 30,631,363 (GRCm39) missense possibly damaging 0.84
R5053:Cpa5 UTSW 6 30,623,271 (GRCm39) missense probably damaging 1.00
R5392:Cpa5 UTSW 6 30,630,829 (GRCm39) nonsense probably null
R5593:Cpa5 UTSW 6 30,630,848 (GRCm39) missense probably benign 0.10
R5745:Cpa5 UTSW 6 30,630,436 (GRCm39) missense probably damaging 1.00
R5900:Cpa5 UTSW 6 30,615,115 (GRCm39) missense probably damaging 1.00
R6264:Cpa5 UTSW 6 30,613,984 (GRCm39) missense probably damaging 1.00
R6268:Cpa5 UTSW 6 30,615,172 (GRCm39) missense probably damaging 1.00
R6376:Cpa5 UTSW 6 30,614,044 (GRCm39) missense probably benign
R6634:Cpa5 UTSW 6 30,626,363 (GRCm39) missense probably damaging 1.00
R6814:Cpa5 UTSW 6 30,614,053 (GRCm39) missense probably benign 0.03
R6872:Cpa5 UTSW 6 30,614,053 (GRCm39) missense probably benign 0.03
R6989:Cpa5 UTSW 6 30,625,891 (GRCm39) missense probably benign 0.06
R7205:Cpa5 UTSW 6 30,630,829 (GRCm39) missense probably benign
R7499:Cpa5 UTSW 6 30,630,856 (GRCm39) missense possibly damaging 0.81
R7864:Cpa5 UTSW 6 30,631,394 (GRCm39) missense probably damaging 0.97
R8170:Cpa5 UTSW 6 30,624,594 (GRCm39) missense probably benign 0.35
R9027:Cpa5 UTSW 6 30,612,604 (GRCm39) start codon destroyed probably null 0.88
R9395:Cpa5 UTSW 6 30,631,280 (GRCm39) missense probably damaging 1.00
R9607:Cpa5 UTSW 6 30,626,338 (GRCm39) missense probably damaging 1.00
R9687:Cpa5 UTSW 6 30,614,041 (GRCm39) missense probably benign
R9794:Cpa5 UTSW 6 30,625,920 (GRCm39) critical splice donor site probably null
Posted On 2014-02-04