Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01760:Rslcan18'

153230

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Rslcan18

Ensembl Gene

ENSMUSG00000074824

Gene Name

regulator of sex-limitation candidate 18

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.153) question?

Stock #

IGL01760

Quality Score

Status

Chromosome

Chromosomal Location

67244677-67262092 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 67262015 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 11 (I11V)

Ref Sequence

ENSEMBL: ENSMUSP00000089111 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000091526]

AlphaFold

Q7M6X5

Predicted Effect

probably benign
Transcript: ENSMUST00000091526
AA Change: I11V

PolyPhen 2 Score 0.037 (Sensitivity: 0.94; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000089111
Gene: ENSMUSG00000074824
AA Change: I11V

Domain	Start	End	E-Value	Type
KRAB	96	156	5.31e-28	SMART
ZnF_C2H2	171	193	4.24e-4	SMART
ZnF_C2H2	199	221	1.56e-2	SMART
ZnF_C2H2	227	249	1.82e-3	SMART
ZnF_C2H2	255	277	1.82e-3	SMART
ZnF_C2H2	283	305	3.26e-5	SMART
ZnF_C2H2	311	333	1.82e-3	SMART
ZnF_C2H2	339	361	1.26e-2	SMART
ZnF_C2H2	367	389	2.12e-4	SMART
ZnF_C2H2	395	417	4.87e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000189620

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgre5	T	A	8: 84,458,586 (GRCm39)	T147S	probably benign	Het
Chst3	A	T	10: 60,022,292 (GRCm39)	V185D	probably damaging	Het
Col14a1	A	C	15: 55,286,855 (GRCm39)	D892A	unknown	Het
Dop1a	A	G	9: 86,401,976 (GRCm39)	T1059A	probably benign	Het
Eif1ad3	A	T	12: 87,843,791 (GRCm39)		probably benign	Het
Erlec1	A	C	11: 30,884,731 (GRCm39)	S441A	probably benign	Het
Frmd4b	G	T	6: 97,285,663 (GRCm39)	T289N	probably damaging	Het
Gm6133	G	A	18: 78,393,390 (GRCm39)	R128Q	probably benign	Het
Gnai2	A	G	9: 107,493,717 (GRCm39)	S155P	probably damaging	Het
Hrob	T	C	11: 102,146,422 (GRCm39)	C233R	probably benign	Het
Hspg2	T	C	4: 137,239,982 (GRCm39)	S517P	possibly damaging	Het
Ighv9-1	C	A	12: 114,057,814 (GRCm39)	E29*	probably null	Het
Lrp1	T	C	10: 127,409,370 (GRCm39)	K1583R	probably benign	Het
Ltbp1	C	T	17: 75,534,145 (GRCm39)	T211M	probably damaging	Het
Mttp	A	G	3: 137,817,497 (GRCm39)	S418P	probably benign	Het
Napa	A	G	7: 15,832,669 (GRCm39)	N23S	possibly damaging	Het
Odf2	C	A	2: 29,804,472 (GRCm39)	Q347K	probably damaging	Het
Ogdhl	A	G	14: 32,061,894 (GRCm39)	D504G	probably damaging	Het
Or10aa1	T	C	1: 173,870,191 (GRCm39)	L225P	probably damaging	Het
Pdxdc1	A	T	16: 13,677,016 (GRCm39)	N273K	probably damaging	Het
Spidr	G	T	16: 15,730,424 (GRCm39)	R664S	possibly damaging	Het
Tead3	T	C	17: 28,552,055 (GRCm39)	N385S	probably benign	Het
Trim13	T	A	14: 61,843,172 (GRCm39)	N396K	probably benign	Het
Trp53bp2	C	T	1: 182,275,993 (GRCm39)	A160V	possibly damaging	Het
Vmn2r69	A	G	7: 85,056,072 (GRCm39)	S689P	possibly damaging	Het
Vmn2r79	A	T	7: 86,651,366 (GRCm39)	Q255L	probably benign	Het
Wsb1	T	C	11: 79,132,867 (GRCm39)	Y276C	probably damaging	Het
Zfp236	G	T	18: 82,639,547 (GRCm39)	N1233K	probably damaging	Het

Other mutations in Rslcan18

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01520:Rslcan18	APN	13	67,250,172 (GRCm39)	missense	probably benign	0.01
R0003:Rslcan18	UTSW	13	67,246,533 (GRCm39)	missense	probably benign	0.01
R0333:Rslcan18	UTSW	13	67,246,686 (GRCm39)	missense	probably damaging	0.99
R0505:Rslcan18	UTSW	13	67,250,183 (GRCm39)	missense	probably benign	0.31
R0525:Rslcan18	UTSW	13	67,260,322 (GRCm39)	missense	probably benign	0.03
R0898:Rslcan18	UTSW	13	67,246,880 (GRCm39)	missense	probably benign	0.02
R1449:Rslcan18	UTSW	13	67,250,164 (GRCm39)	missense	possibly damaging	0.65
R1511:Rslcan18	UTSW	13	67,247,016 (GRCm39)	missense	possibly damaging	0.94
R1575:Rslcan18	UTSW	13	67,256,121 (GRCm39)	intron	probably benign
R1973:Rslcan18	UTSW	13	67,256,087 (GRCm39)	intron	probably benign
R3109:Rslcan18	UTSW	13	67,246,671 (GRCm39)	missense	possibly damaging	0.53
R4707:Rslcan18	UTSW	13	67,246,590 (GRCm39)	missense	probably damaging	1.00
R5277:Rslcan18	UTSW	13	67,246,498 (GRCm39)	missense	probably benign	0.03
R8887:Rslcan18	UTSW	13	67,246,793 (GRCm39)	missense	probably damaging	1.00
R9472:Rslcan18	UTSW	13	67,260,296 (GRCm39)	missense	probably benign	0.11
R9475:Rslcan18	UTSW	13	67,250,128 (GRCm39)	nonsense	probably null

Posted On

2014-02-04