Incidental Mutation 'IGL01760:Gm6133'
ID153237
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm6133
Ensembl Gene ENSMUSG00000090451
Gene Namepredicted gene 6133
Synonyms
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.811) question?
Stock #IGL01760
Quality Score
Status
Chromosome18
Chromosomal Location78349754-78350701 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 78350175 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Glutamine at position 128 (R128Q)
Ref Sequence ENSEMBL: ENSMUSP00000128489 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164064]
Predicted Effect probably benign
Transcript: ENSMUST00000164064
AA Change: R128Q

PolyPhen 2 Score 0.141 (Sensitivity: 0.92; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000128489
Gene: ENSMUSG00000090451
AA Change: R128Q

DomainStartEndE-ValueType
Pfam:Ribosomal_L22 17 151 3.4e-44 PFAM
low complexity region 167 179 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgre5 T A 8: 83,731,957 T147S probably benign Het
BC030867 T C 11: 102,255,596 C233R probably benign Het
Chst3 A T 10: 60,186,470 V185D probably damaging Het
Col14a1 A C 15: 55,423,459 D892A unknown Het
Dopey1 A G 9: 86,519,923 T1059A probably benign Het
Erlec1 A C 11: 30,934,731 S441A probably benign Het
Frmd4b G T 6: 97,308,702 T289N probably damaging Het
Gm2016 A T 12: 87,877,021 probably benign Het
Gnai2 A G 9: 107,616,518 S155P probably damaging Het
Hspg2 T C 4: 137,512,671 S517P possibly damaging Het
Ighv9-1 C A 12: 114,094,194 E29* probably null Het
Lrp1 T C 10: 127,573,501 K1583R probably benign Het
Ltbp1 C T 17: 75,227,150 T211M probably damaging Het
Mttp A G 3: 138,111,736 S418P probably benign Het
Napa A G 7: 16,098,744 N23S possibly damaging Het
Odf2 C A 2: 29,914,460 Q347K probably damaging Het
Ogdhl A G 14: 32,339,937 D504G probably damaging Het
Olfr433 T C 1: 174,042,625 L225P probably damaging Het
Pdxdc1 A T 16: 13,859,152 N273K probably damaging Het
Rslcan18 T C 13: 67,113,951 I11V probably benign Het
Spidr G T 16: 15,912,560 R664S possibly damaging Het
Tead3 T C 17: 28,333,081 N385S probably benign Het
Trim13 T A 14: 61,605,723 N396K probably benign Het
Trp53bp2 C T 1: 182,448,428 A160V possibly damaging Het
Vmn2r69 A G 7: 85,406,864 S689P possibly damaging Het
Vmn2r79 A T 7: 87,002,158 Q255L probably benign Het
Wsb1 T C 11: 79,242,041 Y276C probably damaging Het
Zfp236 G T 18: 82,621,422 N1233K probably damaging Het
Other mutations in Gm6133
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02193:Gm6133 APN 18 78350093 missense probably benign 0.17
R0467:Gm6133 UTSW 18 78350090 missense probably benign 0.41
R3900:Gm6133 UTSW 18 78350150 missense probably benign 0.22
R5770:Gm6133 UTSW 18 78350249 missense probably benign 0.10
R7481:Gm6133 UTSW 18 78349793 start codon destroyed probably benign 0.13
Posted On2014-02-04